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© Michel Huerre
Coupe histologique de foie de patient atteint d'une hépatite C chronique active avec infiltrat (opacité) folliculaire (lymphocytes) (Grossissement X 400). L'hépatite C chronique peut être à l'origine de cirrhose et cancer du foie
Publication : Trends in microbiology

Advances in Analyzing Virus-Induced Alterations of Host Cell Splicing

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Trends in microbiology - 19 Dec 2018

Ashraf U, Benoit-Pilven C, Lacroix V, Navratil V, Naffakh N

Link to Pubmed [PMID] – 30577974

Trends Microbiol. 2019 Mar;27(3):268-281

Alteration of host cell splicing is a common feature of many viral infections which is underappreciated because of the complexity and technical difficulty of studying alternative splicing (AS) regulation. Recent advances in RNA sequencing technologies revealed that up to several hundreds of host genes can show altered mRNA splicing upon viral infection. The observed changes in AS events can be either a direct consequence of viral manipulation of the host splicing machinery or result indirectly from the virus-induced innate immune response or cellular damage. Analysis at a higher resolution with single-cell RNAseq, and at a higher scale with the integration of multiple omics data sets in a systems biology perspective, will be needed to further comprehend this complex facet of virus-host interactions.

https://www.ncbi.nlm.nih.gov/pubmed/30577974