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© Michel Huerre
Coupe histologique de foie de patient atteint d'une hépatite C chronique active avec infiltrat (opacité) folliculaire (lymphocytes) (Grossissement X 400). L'hépatite C chronique peut être à l'origine de cirrhose et cancer du foie
Publication : Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

Highly heterogeneous temperature sensitivity of 2009 pandemic influenza A(H1N1) viral isolates, northern France

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin - 27 Oct 2011

Pelletier I, Rousset D, Enouf V, , Colbere-Garapin F, van der Werf S, Naffakh N

Link to Pubmed [PMID] – 22085602

Euro Surveill. 2011 Oct;16(43)

We assayed the temperature sensitivity of 2009 pandemic influenza A(H1N1) viral isolates (n=23) and seasonal influenza A(H1N1) viruses (n=18) isolated in northern France in 2007/08 and 2008/09. All isolates replicated with a similar efficiency at 34 °C and 37 °C, and with a lower efficiency at 40 °C. The pandemic viral isolates showed a stronger heterogeneity in their ability to grow at the highest temperature, as compared with the seasonal isolates. No statistically significant difference in temperature sensitivity was observed between the pandemic viral isolates from severe and mild cases of influenza. Our data point to the impact of temperature sensitivity on the genetic evolution and diversification of the pandemic influenza A(H1N1) virus since its introduction into the human population in April 2009, and call for close surveillance of this phenotypic marker related to host and tissue tropism.

https://www.ncbi.nlm.nih.gov/pubmed/22085602