Ligne de temps
Nadia Naffakh
Responsable de Structure
05 févr. 2024
publication
The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome.
Lire plus22 mars 2023
07 févr. 2023
publication
High-throughput droplet-based analysis of influenza A virus genetic reassortment by single-virus RNA sequencing.
Lire plus23 mai 2022
publication
Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
Lire plus01 mai 2022
publication
A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors.
Lire plus01 janv. 2021
publication
Single-Cell and Bulk RNA-Sequencing Reveal Differences in Monocyte Susceptibility to Influenza A Virus Infection Between Africans and Europeans.
Lire plus19 déc. 2018
03 sept. 2018
03 sept. 2018
04 avr. 2018
publication
Mutations Conferring Increased Sensitivity to Tripartite Motif 22 Restriction Accumulated Progressively in the Nucleoprotein of Seasonal Influenza A (H1N1) Viruses between 1918 and 2009
Lire plus01 janv. 2018
publication
Metal-Tagging Transmission Electron Microscopy and Immunogold Labeling on Tokuyasu Cryosections to Image Influenza A Virus Ribonucleoprotein Transport and Packaging
Lire plus22 nov. 2017
publication
Comparative Profiling of Ubiquitin Proteasome System Interplay with Influenza A Virus PB2 Polymerase Protein Recapitulating Virus Evolution in Humans
Lire plus09 nov. 2017
publication
Influenza virus genome reaches the plasma membrane via a modified endoplasmic reticulum and Rab11-dependent vesicles
Lire plus21 déc. 2016
publication
Structural basis of an essential interaction between influenza polymerase and Pol II CTD
Lire plus14 nov. 2016
20 oct. 2016
publication
Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations
Lire plus22 sept. 2016
publication
Influenza A Virus Polymerase Recruits the RNA Helicase DDX19 to Promote the Nuclear Export of Viral mRNAs.
Lire plus09 août 2016
15 mars 2016
publication
Time-Resolved Visualisation of Nearly-Native Influenza A Virus Progeny Ribonucleoproteins and Their Individual Components in Live Infected Cells
Lire plus08 janv. 2016
07 sept. 2015
15 août 2015
16 juil. 2015
08 avr. 2015
publication
Temperature-Sensitive Mutants in the Influenza A Virus RNA Polymerase: Alterations in the PA Linker Reduce Nuclear Targeting of the PB1-PA Dimer and Result in Viral Attenuation
Lire plus12 juin 2014
publication
Recruitment of RED-SMU1 complex by Influenza A Virus RNA polymerase to control Viral mRNA splicing
Lire plus02 avr. 2014
publication
Shortening the unstructured, interdomain region of the non-structural protein NS1 of an avian H1N1 influenza virus increases its replication and pathogenicity in chickens
Lire plus05 nov. 2013
publication
Productive infection of human skeletal muscle cells by pandemic and seasonal influenza A(H1N1) viruses
Lire plus21 oct. 2013
publication
CD36-specific antibodies block release of HIV-1 from infected primary macrophages and its transmission to T cells
Lire plus01 oct. 2013
publication
Exploration of binary virus-host interactions using an infectious protein complementation assay.
Lire plus21 nov. 2012
publication
Synthesis and evaluation of novel 3-C-alkylated-Neu5Ac2en derivatives as probes of influenza virus sialidase 150-loop flexibility.
Lire plus10 oct. 2012
publication
Influenza A virus progeny vRNP trafficking in live infected cells studied with the virus-encoded fluorescently tagged PB2 protein
Lire plus06 juil. 2012
publication
The influenza fingerprints: NS1 and M1 proteins contribute to specific host cell ultrastructure signatures upon infection by different influenza A viruses
Lire plus13 juin 2012
publication
HMGB1 protein binds to influenza virus nucleoprotein and promotes viral replication
Lire plus23 nov. 2011
publication
Replication-competent influenza A virus that encodes a split-green fluorescent protein-tagged PB2 polymerase subunit allows live-cell imaging of the virus life cycle
Lire plus27 oct. 2011
publication
Highly heterogeneous temperature sensitivity of 2009 pandemic influenza A(H1N1) viral isolates, northern France
Lire plus19 oct. 2011
publication
Length variations in the NA stalk of an H7N1 influenza virus have opposite effects on viral excretion in chickens and ducks
Lire plus01 sept. 2011
publication
Influenza virus ribonucleoprotein complexes gain preferential access to cellular export machinery through chromatin targeting.
Lire plus10 août 2011
publication
Influenza virus infection induces the nuclear relocalization of the Hsp90 co-chaperone p23 and inhibits the glucocorticoid receptor response.
Lire plus16 mars 2011
publication
The influenza A virus NS1 protein interacts with the nucleoprotein of viral ribonucleoprotein complexes
Lire plus27 janv. 2011
01 sept. 2010
publication
In vitro characterization of naturally occurring influenza H3NA- viruses lacking the NA gene segment: toward a new mechanism of viral resistance?
Lire plus19 mars 2010
publication
[Interspecies transmission, adaptation to humans and pathogenicity of animal influenza viruses]
Lire plus04 nov. 2009
publication
A genetically engineered waterfowl influenza virus with a deletion in the stalk of the neuraminidase has increased virulence for chickens
Lire plus13 mai 2009
publication
April 2009: an outbreak of swine-origin influenza A(H1N1) virus with evidence for human-to-human transmission
Lire plus01 mars 2007
publication
Codon conservation in the influenza A virus genome defines RNA packaging signals
Lire plus01 janv. 2007
publication
Failure of zanamivir therapy for pneumonia in a bone-marrow transplant recipient infected by a zanamivir-sensitive influenza A (H1N1) virus.
Lire plus03 nov. 2005
publication
Recombinant influenza A viruses harboring optimized dicistronic NA segment with an extended native 5′ terminal sequence: induction of heterospecific B and T cell responses in mice
Lire plus01 nov. 2005
publication
Cloning of the chicken RNA polymerase I promoter and use for reverse genetics of influenza A viruses in avian cells
Lire plus10 oct. 2005
publication
The generation of recombinant influenza A viruses expressing a PB2 fusion protein requires the conservation of a packaging signal overlapping the coding and noncoding regions at the 5′ end of the PB2 segment
Lire plus10 mai 2004
publication
Binding of the hemagglutinin from human or equine influenza H3 viruses to the receptor is altered by substitutions at residue 193
Lire plus15 août 2003
publication
Expression of a foreign gene by stable recombinant influenza viruses harboring a dicistronic genomic segment with an internal promoter
Lire plus25 nov. 2002
publication
Differential effect of nucleotide substitutions in the 3′ arm of the influenza A virus vRNA promoter on transcription/replication by avian and human polymerase complexes is related to the nature of PB2 amino acid 627
Lire plus10 oct. 2001
publication
Hemagglutinin residues of recent human A(H3N2) influenza viruses that contribute to the inability to agglutinate chicken erythrocytes
Lire plus05 juil. 2001
publication
The transcription/replication activity of the polymerase of influenza A viruses is not correlated with the level of proteolysis induced by the PA subunit
Lire plus01 juin 2001
publication
Residue 627 of PB2 is a determinant of cold sensitivity in RNA replication of avian influenza viruses
Lire plus01 mai 2000
publication
Genetic analysis of the compatibility between polymerase proteins from human and avian strains of influenza A viruses
Lire plus20 déc. 1999
publication
Comparative analysis of the ability of the polymerase complexes of influenza viruses type A, B and C to assemble into functional RNPs that allow expression and replication of heterotypic model RNA templates in vivo
Lire plus01 mars 1997
publication
Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts
Lire plus01 août 1996
01 janv. 1996
publication
Long-term secretion of therapeutic proteins from genetically modified skeletal muscles
Lire plus11 avr. 1995
publication
Sustained delivery of erythropoietin in mice by genetically modified skin fibroblasts
Lire plus01 janv. 1995
01 janv. 1994
01 sept. 1993
15 août 1993
publication
Disappearance of lysosomal storage in spleen and liver of mucopolysaccharidosis VII mice after transplantation of genetically modified bone marrow cells
Lire plus15 mai 1993
publication
Macrophage colony-stimulating factor: serum levels and cDNA structure in malignant osteopetrosis
Lire plus01 janv. 1991