Timeline

Nadia Naffakh
Head of Structure
10 May 2019
publication

Destabilization of the human RED-SMU1 splicing complex as a basis for host-directed antiinfluenza strategy

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19 Dec 2018
publication

Advances in Analyzing Virus-Induced Alterations of Host Cell Splicing

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03 Sep 2018
project

Trafficking and assembly of influenza virus genomic RNAs

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03 Sep 2018
tool

Engineered influenza viruses expressing a tagged polymerase subunit

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04 Apr 2018
publication

Mutations Conferring Increased Sensitivity to Tripartite Motif 22 Restriction Accumulated Progressively in the Nucleoprotein of Seasonal Influenza A (H1N1) Viruses between 1918 and 2009

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01 Jan 2018
publication

Metal-Tagging Transmission Electron Microscopy and Immunogold Labeling on Tokuyasu Cryosections to Image Influenza A Virus Ribonucleoprotein Transport and Packaging

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22 Nov 2017
publication

Comparative Profiling of Ubiquitin Proteasome System Interplay with Influenza A Virus PB2 Polymerase Protein Recapitulating Virus Evolution in Humans

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09 Nov 2017
publication

Influenza virus genome reaches the plasma membrane via a modified endoplasmic reticulum and Rab11-dependent vesicles

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21 Dec 2016
publication

Structural basis of an essential interaction between influenza polymerase and Pol II CTD

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14 Nov 2016
news

SEMINAR OF THE VIROLOGY DEPARTMENT

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20 Oct 2016
publication

Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations

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22 Sep 2016
publication

Influenza A Virus Polymerase Recruits the RNA Helicase DDX19 to Promote the Nuclear Export of Viral mRNAs

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09 Aug 2016
publication

Experimental Approaches to Study Genome Packaging of Influenza A Viruses

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15 Mar 2016
publication

Time-Resolved Visualisation of Nearly-Native Influenza A Virus Progeny Ribonucleoproteins and Their Individual Components in Live Infected Cells

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08 Jan 2016
publication

Targeting host calpain proteases decreases influenza A virus infection

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07 Sep 2015
tool

High-throughput protein-protein interaction assay based on a split-luciferase

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15 Aug 2015
project

Molecular mechanism of transcription by influenza virus polymerase

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16 Jul 2015
team

RNA Biology of Influenza Virus

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08 Apr 2015
publication

Temperature-Sensitive Mutants in the Influenza A Virus RNA Polymerase: Alterations in the PA Linker Reduce Nuclear Targeting of the PB1-PA Dimer and Result in Viral Attenuation

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12 Jun 2014
publication

Recruitment of RED-SMU1 complex by Influenza A Virus RNA polymerase to control Viral mRNA splicing

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02 Apr 2014
publication

Shortening the unstructured, interdomain region of the non-structural protein NS1 of an avian H1N1 influenza virus increases its replication and pathogenicity in chickens

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05 Nov 2013
publication

Productive infection of human skeletal muscle cells by pandemic and seasonal influenza A(H1N1) viruses

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21 Oct 2013
publication

CD36-specific antibodies block release of HIV-1 from infected primary macrophages and its transmission to T cells

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01 Jul 2013
publication

Exploration of binary virus-host interactions using an infectious protein complementation assay

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21 Nov 2012
publication

Synthesis and evaluation of novel 3-C-alkylated-Neu5Ac2en derivatives as probes of influenza virus sialidase 150-loop flexibility

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10 Oct 2012
publication

Influenza A virus progeny vRNP trafficking in live infected cells studied with the virus-encoded fluorescently tagged PB2 protein

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06 Jul 2012
publication

The influenza fingerprints: NS1 and M1 proteins contribute to specific host cell ultrastructure signatures upon infection by different influenza A viruses

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13 Jun 2012
publication

HMGB1 protein binds to influenza virus nucleoprotein and promotes viral replication

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23 Nov 2011
publication

Replication-competent influenza A virus that encodes a split-green fluorescent protein-tagged PB2 polymerase subunit allows live-cell imaging of the virus life cycle

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27 Oct 2011
publication

Highly heterogeneous temperature sensitivity of 2009 pandemic influenza A(H1N1) viral isolates, northern France

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19 Oct 2011
publication

Length variations in the NA stalk of an H7N1 influenza virus have opposite effects on viral excretion in chickens and ducks

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01 Sep 2011
publication

Influenza virus ribonucleoprotein complexes gain preferential access to cellular export machinery through chromatin targeting

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10 Aug 2011
publication

Influenza virus infection induces the nuclear relocalization of the Hsp90 co-chaperone p23 and inhibits the glucocorticoid receptor response

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16 Mar 2011
publication

The influenza A virus NS1 protein interacts with the nucleoprotein of viral ribonucleoprotein complexes

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27 Jan 2011
publication

Confronting influenza virus: a common but ever-changing pathogen

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01 Jan 2011
publication

Neuraminidase of 2007-2008 influenza A(H1N1) viruses shows increased affinity for sialic acids due to the D344N substitution

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16 Nov 2010
publication

Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase

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01 Sep 2010
publication

In vitro characterization of naturally occurring influenza H3NA- viruses lacking the NA gene segment: toward a new mechanism of viral resistance?

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19 Mar 2010
publication

[Interspecies transmission, adaptation to humans and pathogenicity of animal influenza viruses]

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30 Dec 2009
publication

Enhancement of the influenza A hemagglutinin (HA)-mediated cell-cell fusion and virus entry by the viral neuraminidase (NA)

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04 Nov 2009
publication

A genetically engineered waterfowl influenza virus with a deletion in the stalk of the neuraminidase has increased virulence for chickens

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13 May 2009
publication

April 2009: an outbreak of swine-origin influenza A(H1N1) virus with evidence for human-to-human transmission

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18 Feb 2009
publication

Neuraminidase stalk length and additional glycosylation of the hemagglutinin influence the virulence of influenza H5N1 viruses for mice

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19 Nov 2008
publication

Avian Influenza A virus polymerase association with nucleoprotein, but not polymerase assembly, is impaired in human cells during the course of infection

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01 Jan 2008
publication

Host restriction of avian influenza viruses at the level of the ribonucleoproteins

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01 Mar 2007
publication

Codon conservation in the influenza A virus genome defines RNA packaging signals

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31 Jan 2007
publication

Host-range determinants on the PB2 protein of influenza A viruses control the interaction between the viral polymerase and nucleoprotein in human cells

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01 Jan 2007
publication

Failure of zanamivir therapy for pneumonia in a bone-marrow transplant recipient infected by a zanamivir-sensitive influenza A (H1N1) virus

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28 Aug 2006
publication

Natural variation can significantly alter the sensitivity of influenza A (H5N1) viruses to oseltamivir

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03 Nov 2005
publication

Recombinant influenza A viruses harboring optimized dicistronic NA segment with an extended native 5′ terminal sequence: induction of heterospecific B and T cell responses in mice

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01 Nov 2005
publication

Cloning of the chicken RNA polymerase I promoter and use for reverse genetics of influenza A viruses in avian cells

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10 Oct 2005
publication

The generation of recombinant influenza A viruses expressing a PB2 fusion protein requires the conservation of a packaging signal overlapping the coding and noncoding regions at the 5′ end of the PB2 segment

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10 May 2004
publication

Binding of the hemagglutinin from human or equine influenza H3 viruses to the receptor is altered by substitutions at residue 193

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15 Aug 2003
publication

Expression of a foreign gene by stable recombinant influenza viruses harboring a dicistronic genomic segment with an internal promoter

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25 Nov 2002
publication

Differential effect of nucleotide substitutions in the 3′ arm of the influenza A virus vRNA promoter on transcription/replication by avian and human polymerase complexes is related to the nature of PB2 amino acid 627

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10 Oct 2001
publication

Hemagglutinin residues of recent human A(H3N2) influenza viruses that contribute to the inability to agglutinate chicken erythrocytes

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05 Jul 2001
publication

The transcription/replication activity of the polymerase of influenza A viruses is not correlated with the level of proteolysis induced by the PA subunit

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01 Jun 2001
publication

Residue 627 of PB2 is a determinant of cold sensitivity in RNA replication of avian influenza viruses

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01 May 2000
publication

Genetic analysis of the compatibility between polymerase proteins from human and avian strains of influenza A viruses

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20 Dec 1999
publication

Comparative analysis of the ability of the polymerase complexes of influenza viruses type A, B and C to assemble into functional RNPs that allow expression and replication of heterotypic model RNA templates in vivo

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01 Mar 1997
publication

Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts

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01 Aug 1996
publication

Gene transfer for erythropoiesis enhancement

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01 Jan 1996
publication

Long-term secretion of therapeutic proteins from genetically modified skeletal muscles

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11 Apr 1995
publication

Sustained delivery of erythropoietin in mice by genetically modified skin fibroblasts

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01 Jan 1995
publication

Delivery of therapeutic proteins from genetically-modified cells

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01 Jan 1994
publication

Gene therapy for lysosomal disorders

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01 Sep 1993
publication

Transplantation of adult-derived myoblasts in mice following gene transfer

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15 Aug 1993
publication

Disappearance of lysosomal storage in spleen and liver of mucopolysaccharidosis VII mice after transplantation of genetically modified bone marrow cells

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15 May 1993
publication

Macrophage colony-stimulating factor: serum levels and cDNA structure in malignant osteopetrosis

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01 Jan 1991
publication

Gene transfer to somatic tissues using retroviral vectors

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