Timeline

Nicolas Wolff

Group Leader

03 Oct 2024

course

Structure et fonction des protéines

31 Jul 2023

project

HORIZON-MSCA-DN CLEXM Project

26 Jul 2023

publication

Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants.

01 Jan 2023

publication

Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity.

01 Jan 2022

publication

Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins.

01 Jan 2022

publication

Deciphering the Molecular Interaction Between the Adhesion G Protein-Coupled Receptor ADGRV1 and its PDZ-Containing Regulator PDZD7.

15 Nov 2021

publication

PDZ-Containing Proteins Targeted by the ACE2 Receptor.

30 Sep 2021

course

Biochimie des Protéines

23 Jun 2021

event

Internal Seminar Dept Neuroscience “Molecular organization and regulation of the Usher2 complex, a protein assembly related to deafness and blindness”, Nicolas Wolff

17 Apr 2021

publication

Host PDZ-containing proteins targeted by SARS-Cov-2.

14 Apr 2021

publication

Phylogenetic analysis of Harmonin homology domains.

05 Feb 2021

publication

Role of PDZ-binding motif from West Nile virus NS5 protein on viral replication.

13 Jan 2021

publication

Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein.

01 Jan 2021

publication

PDZ Sample Quality Assessment by Biochemical and Biophysical Characterizations.

01 Jan 2021

publication

Automatic Bayesian Weighting for SAXS Data.

08 Dec 2020

publication

Ultrarare heterozygous pathogenic variants of genes causing dominant forms of early-onset deafness underlie severe presbycusis.

06 Nov 2020

publication

Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners.

13 Oct 2020

course

Biochimie des Protéines

02 Oct 2020

publication

Interaction of protocadherin-15 with the scaffold protein whirlin supports its anchoring of hair-bundle lateral links in cochlear hair cells.

18 Aug 2020

publication

Hidden kinetic traps in multidomain folding highlight the presence of a misfolded but functionally competent intermediate.

16 Jul 2020

project

Identification of cellular PDZ-containing Proteins targeted by the virus SARS-Cov-2 during infection (PPCOVi)

14 Nov 2019

event

DPT NEUROSCIENCE – Thesis defence : Mariano GENERA – Structural and functional study of the human phosphatase PTPN3 and its interaction with oncogenic viruses.

25 Jul 2019

publication

Structure-based optimization of a PDZ-binding motif within a viral peptide stimulates neurite outgrowth

01 Jan 2019

publication

High-Throughput Production of a New Library of Human Single and Tandem PDZ Domains Allows Quantitative PDZ-Peptide Interaction Screening Through High-Throughput Holdup Assay

05 Sep 2018

publication

Structural plasticity of the HHD2 domain of whirlin.

09 Mar 2018

publication

Tuning interval Branch-and-Prune for protein structure determination

08 Feb 2018

project

Mutations in PDZ Binding Motif (PBM)-containing proteins associated to the Usher syndrome

08 Feb 2018

project

Rabies virus neuronal infection

31 Oct 2017

publication

Interfering peptides targeting protein-protein interactions: the next generation of drugs?

28 Sep 2017

publication

Structural Characterization of Whirlin Reveals an Unexpected and Dynamic Supramodule Conformation of Its PDZ Tandem

09 Sep 2015

tool

Nuclear Magnetic Resonance spectrometers

16 Jul 2015

team

Signalling and Molecular interactions

08 Jun 2015

publication

Quantifying domain-ligand affinities and specificities by high-throughput holdup assay

05 May 2015

publication

Deciphering the unconventional peptide binding to the PDZ domain of MAST2

05 Mar 2015

publication

Strategies to interfere with PDZ-mediated interactions in neurons: What we can learn from the rabies virus.

18 Oct 2014

publication

Quantitative and dynamic analysis of PTEN phosphorylation by NMR

30 Sep 2014

publication

Regulation of the catalytic activity of the human phosphatase PTPN4 by its PDZ domain.

21 Sep 2014

team

Signaling and receptors dynamics

01 Jul 2014

publication

A unified nomenclature and amino acid numbering for human PTEN.

07 Dec 2012

publication

Ordered phosphorylation events in two independent cascades of the PTEN C-tail revealed by NMR

12 Oct 2011

publication

Peptides targeting the PDZ domain of PTPN4 are efficient inducers of glioblastoma cell death

13 Jan 2009

publication

1H, 13C and 15N resonance assignments of the PDZ of microtubule-associated serine/threonine kinase 205 (MAST205) in complex with the C-terminal motif from the rabies virus glycoprotein

04 Dec 2007

publication

Comparative analysis of structural and dynamic properties of the loaded and unloaded hemophore HasA: functional implications

18 Apr 2006

publication

Structural and functional characterization of the TgDRE multidomain protein, a DNA repair enzyme from Toxoplasma gondii

01 Aug 2004

publication

Exploring structural features of the interaction between the scorpion toxinCnErg1 and ERG K+ channels

26 Jun 2003

publication

Antifolding activity of the SecB chaperone is essential for secretion of HasA, a quickly folding ABC pathway substrate

01 Apr 2002

publication

A little guide for advanced search:

Structure et fonction des protéines

HORIZON-MSCA-DN CLEXM Project

Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants.

Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity.

Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins.

Deciphering the Molecular Interaction Between the Adhesion G Protein-Coupled Receptor ADGRV1 and its PDZ-Containing Regulator PDZD7.

PDZ-Containing Proteins Targeted by the ACE2 Receptor.

Biochimie des Protéines

Internal Seminar Dept Neuroscience “Molecular organization and regulation of the Usher2 complex, a protein assembly related to deafness and blindness”, Nicolas Wolff

Host PDZ-containing proteins targeted by SARS-Cov-2.

Phylogenetic analysis of Harmonin homology domains.

Role of PDZ-binding motif from West Nile virus NS5 protein on viral replication.

Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein.

PDZ Sample Quality Assessment by Biochemical and Biophysical Characterizations.

Automatic Bayesian Weighting for SAXS Data.

Ultrarare heterozygous pathogenic variants of genes causing dominant forms of early-onset deafness underlie severe presbycusis.

Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners.

Biochimie des Protéines

Interaction of protocadherin-15 with the scaffold protein whirlin supports its anchoring of hair-bundle lateral links in cochlear hair cells.

Hidden kinetic traps in multidomain folding highlight the presence of a misfolded but functionally competent intermediate.

Identification of cellular PDZ-containing Proteins targeted by the virus SARS-Cov-2 during infection (PPCOVi)

DPT NEUROSCIENCE – Thesis defence : Mariano GENERA – Structural and functional study of the human phosphatase PTPN3 and its interaction with oncogenic viruses.

Structure-based optimization of a PDZ-binding motif within a viral peptide stimulates neurite outgrowth

High-Throughput Production of a New Library of Human Single and Tandem PDZ Domains Allows Quantitative PDZ-Peptide Interaction Screening Through High-Throughput Holdup Assay

Structural plasticity of the HHD2 domain of whirlin.

Tuning interval Branch-and-Prune for protein structure determination

Mutations in PDZ Binding Motif (PBM)-containing proteins associated to the Usher syndrome

Rabies virus neuronal infection

Interfering peptides targeting protein-protein interactions: the next generation of drugs?

Structural Characterization of Whirlin Reveals an Unexpected and Dynamic Supramodule Conformation of Its PDZ Tandem

Nuclear Magnetic Resonance spectrometers

Signalling and Molecular interactions

Quantifying domain-ligand affinities and specificities by high-throughput holdup assay

Deciphering the unconventional peptide binding to the PDZ domain of MAST2

Strategies to interfere with PDZ-mediated interactions in neurons: What we can learn from the rabies virus.

Quantitative and dynamic analysis of PTEN phosphorylation by NMR

Regulation of the catalytic activity of the human phosphatase PTPN4 by its PDZ domain.

Signaling and receptors dynamics

A unified nomenclature and amino acid numbering for human PTEN.

Ordered phosphorylation events in two independent cascades of the PTEN C-tail revealed by NMR

Peptides targeting the PDZ domain of PTPN4 are efficient inducers of glioblastoma cell death

1H, 13C and 15N resonance assignments of the PDZ of microtubule-associated serine/threonine kinase 205 (MAST205) in complex with the C-terminal motif from the rabies virus glycoprotein

Comparative analysis of structural and dynamic properties of the loaded and unloaded hemophore HasA: functional implications

Structural and functional characterization of the TgDRE multidomain protein, a DNA repair enzyme from Toxoplasma gondii

Exploring structural features of the interaction between the scorpion toxinCnErg1 and ERG K+ channels

Antifolding activity of the SecB chaperone is essential for secretion of HasA, a quickly folding ABC pathway substrate

Histidine pK(a) shifts and changes of tautomeric states induced by the binding of gallium-protoporphyrin IX in the hemophore HasA(SM)