Timeline

Ludovic Sauguet

Permanent Researcher

06 Dec 2024

publication

Crystal structures of monomeric BsmI restriction endonuclease reveal a coordinated action of its two distinct active sites to sequentially cleave the two DNA strands

12 Jul 2024

event

3rd Drug Discovery & Screening Symposium – “Innovative Therapeutics: Small Molecules and Biologics in Modern Medicine” – an ATC-DDS initiative

14 Dec 2023

publication

Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases.

21 Jun 2023

publication

The universal Sua5/TsaC family evolved different mechanisms for the synthesis of a key tRNA modification

27 Apr 2023

event

First Ice Day : Symposium of the nanoimaging Cryo-EM core facility users

27 Apr 2023

project

DNA-binding mechanism and evolution of replication protein A

22 Apr 2023

publication

DNA-binding mechanism and evolution of replication protein A.

22 Apr 2022

project

STRUCTURAL BASIS FOR DNA REPLICATION AND REPLICATION-COUPLED DNA REPAIR IN ARCHAEA

21 Apr 2022

team

DNA replication group

20 Jan 2021

project

DNA Replisome in Archaea

01 Jan 2021

publication

Fast and efficient purification of SARS-CoV-2 RNA dependent RNA polymerase complex expressed in Escherichia coli.

02 Dec 2020

publication

Novel ribonucleotide discrimination in the RNA polymerase-like two-barrel catalytic core of Family D DNA polymerases.

27 Mar 2020

publication

Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA.

20 Sep 2019

publication

The Extended “Two-Barrel” Polymerases Superfamily: Structure, Function and Evolution.

20 Sep 2019

publication

The Extended “Two-Barrel” Polymerases Superfamily: Structure, Function and Evolution

18 Sep 2019

event

Department of Structural Biology and Chemistry Department: Prof. Xiadong Zhang, Structures and Mechanisms of Transcription Initiation and Regulation

28 Feb 2019

publication

An updated structural classification of replicative DNA polymerases.

18 Jan 2019

publication

Structure of the DP1–DP2 PolD complex bound with DNA and its implications for the evolutionary history of DNA and RNA polymerases

01 Jan 2019

publication

Structure of the DP1-DP2 PolD complex bound with DNA and its implications for the evolutionary history of DNA and RNA polymerases.

12 Dec 2018

publication

Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel

24 Apr 2018

publication

Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels

09 Apr 2018

publication

Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation

01 Oct 2016

publication

Vaccination Against Human Papilloma Viruses Leads to a Favorable Cytokine Profile of Specific T Cells

22 Aug 2016

publication

Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography.

15 Jun 2016

publication

Neurotoxic phospholipase A2 from rattlesnake as a new ligand and new regulator of prokaryotic receptor GLIC (proton-gated ion channel from G. violaceus).

24 Mar 2016

publication

Sites of Anesthetic Inhibitory Action on a Cationic Ligand-Gated Ion Channel

24 Feb 2016

publication

Structural Basis for Xenon Inhibition in a Cationic Pentameric Ligand-Gated Ion Channel

01 Jan 2016

publication

Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography.

11 May 2015

team

Architecture and Dynamics of Biological Macromolecules

03 Mar 2015

publication

Allosteric and hyperekplexic mutant phenotypes investigated on an α1 glycine receptor transmembrane structure.

14 May 2014

publication

Crystallographic studies of pharmacological sites in pentameric ligand-gated ion channels

23 Dec 2013

publication

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation

12 Feb 2013

publication

Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels

01 Jan 2013

publication

Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel

03 Oct 2012

publication

Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines

06 Jun 2012

publication

Structure and pharmacology of pentameric receptor channels: from bacteria to brain

13 May 2012

publication

A little guide for advanced search:

Timeline

Crystal structures of monomeric BsmI restriction endonuclease reveal a coordinated action of its two distinct active sites to sequentially cleave the two DNA strands

3rd Drug Discovery & Screening Symposium – “Innovative Therapeutics: Small Molecules and Biologics in Modern Medicine” – an ATC-DDS initiative

Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases.

The universal Sua5/TsaC family evolved different mechanisms for the synthesis of a key tRNA modification

First Ice Day : Symposium of the nanoimaging Cryo-EM core facility users

DNA-binding mechanism and evolution of replication protein A

DNA-binding mechanism and evolution of replication protein A.

STRUCTURAL BASIS FOR DNA REPLICATION AND REPLICATION-COUPLED DNA REPAIR IN ARCHAEA

DNA replication group

DNA Replisome in Archaea

Fast and efficient purification of SARS-CoV-2 RNA dependent RNA polymerase complex expressed in Escherichia coli.

Novel ribonucleotide discrimination in the RNA polymerase-like two-barrel catalytic core of Family D DNA polymerases.

Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA.

The Extended “Two-Barrel” Polymerases Superfamily: Structure, Function and Evolution.

The Extended “Two-Barrel” Polymerases Superfamily: Structure, Function and Evolution

Department of Structural Biology and Chemistry Department: Prof. Xiadong Zhang, Structures and Mechanisms of Transcription Initiation and Regulation

An updated structural classification of replicative DNA polymerases.

Structure of the DP1–DP2 PolD complex bound with DNA and its implications for the evolutionary history of DNA and RNA polymerases

Structure of the DP1-DP2 PolD complex bound with DNA and its implications for the evolutionary history of DNA and RNA polymerases.

Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel

Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels

Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation

Vaccination Against Human Papilloma Viruses Leads to a Favorable Cytokine Profile of Specific T Cells

Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography.

Neurotoxic phospholipase A2 from rattlesnake as a new ligand and new regulator of prokaryotic receptor GLIC (proton-gated ion channel from G. violaceus).

Sites of Anesthetic Inhibitory Action on a Cationic Ligand-Gated Ion Channel

Structural Basis for Xenon Inhibition in a Cationic Pentameric Ligand-Gated Ion Channel

Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography.

Architecture and Dynamics of Biological Macromolecules

Allosteric and hyperekplexic mutant phenotypes investigated on an α1 glycine receptor transmembrane structure.

Crystallographic studies of pharmacological sites in pentameric ligand-gated ion channels

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation

Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels

Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel

Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines

Structure and pharmacology of pentameric receptor channels: from bacteria to brain

A locally closed conformation of a bacterial pentameric proton-gated ion channel