Ligne de temps
Ludovic Sauguet
Chercheur(euse) Permanent(e)
06 déc. 2024
publication
Crystal structures of monomeric BsmI restriction endonuclease reveal a coordinated action of its two distinct active sites to sequentially cleave the two DNA strands
Lire plus12 juil. 2024
event
3rd Drug Discovery & Screening Symposium – “Innovative Therapeutics: Small Molecules and Biologics in Modern Medicine” – an ATC-DDS initiative
Lire plus14 déc. 2023
publication
Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases.
Lire plus21 juin 2023
publication
The universal Sua5/TsaC family evolved different mechanisms for the synthesis of a key tRNA modification
Lire plus27 avr. 2023
27 avr. 2023
22 avr. 2023
22 avr. 2022
project
STRUCTURAL BASIS FOR DNA REPLICATION AND REPLICATION-COUPLED DNA REPAIR IN ARCHAEA
Lire plus21 avr. 2022
20 janv. 2021
01 janv. 2021
publication
Fast and efficient purification of SARS-CoV-2 RNA dependent RNA polymerase complex expressed in Escherichia coli.
Lire plus02 déc. 2020
publication
Novel ribonucleotide discrimination in the RNA polymerase-like two-barrel catalytic core of Family D DNA polymerases.
Lire plus27 mars 2020
publication
Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA.
Lire plus20 sept. 2019
publication
The Extended “Two-Barrel” Polymerases Superfamily: Structure, Function and Evolution.
Lire plus20 sept. 2019
publication
The Extended “Two-Barrel” Polymerases Superfamily: Structure, Function and Evolution
Lire plus18 sept. 2019
event
Department of Structural Biology and Chemistry Department: Prof. Xiadong Zhang, Structures and Mechanisms of Transcription Initiation and Regulation
Lire plus28 févr. 2019
18 janv. 2019
publication
Structure of the DP1–DP2 PolD complex bound with DNA and its implications for the evolutionary history of DNA and RNA polymerases
Lire plus01 janv. 2019
publication
Structure of the DP1-DP2 PolD complex bound with DNA and its implications for the evolutionary history of DNA and RNA polymerases.
Lire plus12 déc. 2018
publication
Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel
Lire plus24 avr. 2018
publication
Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels
Lire plus09 avr. 2018
publication
Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation
Lire plus01 oct. 2016
publication
Vaccination Against Human Papilloma Viruses Leads to a Favorable Cytokine Profile of Specific T Cells
Lire plus22 août 2016
publication
Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography.
Lire plus15 juin 2016
publication
Neurotoxic phospholipase A2 from rattlesnake as a new ligand and new regulator of prokaryotic receptor GLIC (proton-gated ion channel from G. violaceus).
Lire plus24 mars 2016
24 févr. 2016
publication
Structural Basis for Xenon Inhibition in a Cationic Pentameric Ligand-Gated Ion Channel
Lire plus01 janv. 2016
publication
Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography.
Lire plus11 mai 2015
03 mars 2015
publication
Allosteric and hyperekplexic mutant phenotypes investigated on an α1 glycine receptor transmembrane structure.
Lire plus14 mai 2014
publication
Crystallographic studies of pharmacological sites in pentameric ligand-gated ion channels
Lire plus23 déc. 2013
publication
Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation
Lire plus12 févr. 2013
publication
Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels
Lire plus01 janv. 2013
publication
Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel
Lire plus03 oct. 2012
publication
Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines
Lire plus06 juin 2012
publication
Structure and pharmacology of pentameric receptor channels: from bacteria to brain
Lire plus13 mai 2012
publication