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© Structural Dynamics Of Macromolecules
The structure of a bacterial analog of the nicotinic receptor (one color per subunit) inserted into the cell membrane (grey and orange). A representation of the volume accessible to ions is shown in yellow.
Event

Department of Structural Biology and Chemistry Department: Prof. Xiadong Zhang, Structures and Mechanisms of Transcription Initiation and Regulation

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
01
Oct 2019
Time
14:00:00
28 Rue du Dr Roux, Paris, France
Address
Building: François Jacob building
Location
2019-10-01 14:00:00 2019-10-01 15:30:00 Europe/Paris Department of Structural Biology and Chemistry Department: Prof. Xiadong Zhang, Structures and Mechanisms of Transcription Initiation and Regulation Séminaire du Département de Biologie Structurale et Chimie   Tuesday 1 october 2019 at 2.00 pm François Jacob Auditorium room – CFJ RdC 17c Prof. Xiadong Zhang Section of Structural Biology, Department of Infectious Diseases, […] 28 Rue du Dr Roux, Paris, France Ludovic Sauguet ludovic.sauguet@pasteur.fr

About

Séminaire du Département de Biologie Structurale et Chimie

 

Tuesday 1 october 2019 at 2.00 pm
François Jacob Auditorium room – CFJ RdC 17c

Prof. Xiadong Zhang
Section of Structural Biology, Department of Infectious Diseases, Imperial College London- 104, Sir Alexander Fleming Building, South Kensington

 

Structures and Mechanisms of Transcription Initiation and Regulation

 Gene transcription is a fundamental cellular process that is carried out by the multi-subunit RNA polymerase (RNAP), which is conserved from bacteria to human. Transcription is highly controlled and many regulatory factors/strategies act on initiation, which involves the opening up the double-strand DNA into single strands and the delivery of the DNA template into the RNAP active centre. Transcription initiation is a highly dynamic process, and has thus been difficult to be studied structurally. We use a special form of bacterial RNAP, which allows us to trap intermediate states. I will discuss our recent progress in unravelling the detailed molecular mechanism of transcription initiation process including how DNA is opened up and delivered into the active centre for transcription and the roles of specialised activator proteins that belong to the large AAA ATPase family.

 

Contact: Ludovic Sauguet
 Structural Dynamics of macromolecules
Ludovic.sauguet@pasteur.fr

Location

Building: François Jacob building
Address: 28 Rue du Dr Roux, Paris, France