Timeline

Vincenzo Di Bartolo

Permanent Researcher

05 Mar 2024

publication

Cancer-on-a-chip model shows that the adenomatous polyposis coli mutation impairs T cell engagement and killing of cancer spheroids

18 Jul 2023

publication

T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations

15 Apr 2022

news

New publication – The tumor suppressor Adenomatous polyposis coli regulates T lymphocyte migration

15 Apr 2022

publication

The tumor suppressor adenomatous polyposis coli regulates T lymphocyte migration.

06 Oct 2021

publication

Cell Polarity Regulators, Multifunctional Organizers of Lymphocyte Activation and Function.

21 Oct 2020

publication

Coordinating Cytoskeleton and Molecular Traffic in T Cell Migration, Activation, and Effector Functions.

24 Jun 2020

publication

Adenomatous Polyposis Coli Modulates Actin and Microtubule Cytoskeleton at the Immunological Synapse to Tune CTL Functions.

10 Mar 2020

publication

ERM-Dependent Assembly of T Cell Receptor Signaling and Co-stimulatory Molecules on Microvilli prior to Activation.

01 Jul 2019

publication

Histamine releasing factor and elongation factor 1 alpha secreted via malaria parasites extracellular vesicles promote immune evasion by inhibiting specific T cell responses.

07 Mar 2019

project

Projet de Recherche Clinique : Impact des mutations du gène APC (Adenomatous polyposis coli) dans les réponses immunes anti-tumorales

12 Oct 2018

project

CoSImmGEn-F : constitution d’une cohorte de sujets atteints de polypose adénomateuse familiale et porteurs d’une mutation du gène APC afin d’étudier le rôle de la génétique du système immunitaire et de l’environnement dans la maladie

03 Oct 2018

publication

HIV-1 Nef Hijacks Lck and Rac1 Endosomal Traffic To Dually Modulate Signaling-Mediated and Actin Cytoskeleton-Mediated T Cell Functions.

26 Apr 2018

publication

Cell Biology of T Cell Receptor Expression and Regulation.

03 Oct 2017

publication

Adenomatous Polyposis Coli Defines Treg Differentiation and Anti-inflammatory Function through Microtubule-Mediated NFAT Localization.

24 Feb 2017

publication

Rab11-FIP3 Regulation of Lck Endosomal Traffic Controls TCR Signal Transduction.

20 Jan 2017

publication

Serine Phosphorylation of SLP76 Is Dispensable for T Cell Development but Modulates Helper T Cell Function.

22 Jun 2016

project

Think tank: Cancer

06 May 2016

publication

Rac1-Rab11-FIP3 regulatory hub coordinates vesicle traffic with actin remodeling and T-cell activation.

28 Jan 2016

publication

Comparative Anatomy of Phagocytic and Immunological Synapses.

01 Jan 2016

publication

Editorial: Molecular Dynamics at the Immunological Synapse.

07 Jul 2015

project

How the dynamics of signaling complexes at the immunological synapse controls T cell activation

06 Jul 2015

project

Cytoskeleton, immunological synapse and T cell activation: role of Ezrin and Adenomatous polyposis coli

11 May 2015

team

Immunoregulation

21 Nov 2011

publication

Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation.

18 Jul 2011

publication

Mycolactone impairs T cell homing by suppressing microRNA control of L-selectin expression.

21 Apr 2011

publication

The Shigella flexneri type three secretion system effector IpgD inhibits T cell migration by manipulating host phosphoinositide metabolism.

15 Jun 2010

publication

Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse.

30 Dec 2009

publication

Mycolactone suppresses T cell responsiveness by altering both early signaling and posttranslational events.

01 Sep 2008

publication

Tailoring T-cell receptor signals by proximal negative feedback mechanisms.

19 Mar 2007

publication

A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76.

11 Jan 2007

publication

ZAP-70 kinase regulates HIV cell-to-cell spread and virological synapse formation.

01 Dec 2005

publication

CD8 T cell sensory adaptation dependent on TCR avidity for self-antigens.

01 Feb 2005

publication

Sequence tag scanning: a new explorative strategy for recognition of unexpected protein alterations by nanoelectrospray ionization-tandem mass spectrometry

01 Aug 2004

publication

Large-scale screening for genes involved in T-cell signaling: do we know all the players now?

01 Apr 2004

publication

T-cell receptor-induced phosphorylation of the zeta chain is efficiently promoted by ZAP-70 but not Syk

01 Sep 2003

publication

Proximal changes in signal transduction that modify CD8+ T cell responsiveness in vivo

01 Jan 2003

publication

Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor

01 Oct 2002

publication

In the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern

15 Aug 2002

publication

TCR/CD3 down-modulation and zeta degradation are regulated by ZAP-70.

01 Feb 2002

publication

Tyrosine 315 determines optimal recruitment of ZAP-70 to the T cell antigen receptor.

20 Aug 2001

publication

T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase

18 Jun 2001

publication

Functional dichotomy in natural killer cell signaling: Vav1-dependent and -independent mechanisms

25 Oct 1999

publication

The Rift Valley fever virus nonstructural protein NSs is phosphorylated at serine residues located in casein kinase II consensus motifs in the carboxy-terminus.

15 Aug 1999

publication

Redundant role of the Syk protein tyrosine kinase in mouse NK cell differentiation

14 May 1999

publication

Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck.

05 Mar 1999

publication

Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling.

15 Sep 1998

publication

An improved retroviral gene transfer technique demonstrates inhibition of CD4-CD8- thymocyte development by kinase-inactive ZAP-70

01 Jan 1997

publication

Further evidence for an endogenous digitalis-like compound in newborn and adult plasma detected by anti-ouabain antiserum

20 Dec 1996

publication

Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathways.

01 Jan 1996

publication

Binding of human GM-CSF to synthetic peptides of the alpha subunit of its receptor

01 Jun 1995

publication

The stimulatory effect on human erythrocyte rubidium-86 uptake by anti-cardiac-glycoside antibodies

27 Feb 1995

publication

Autoantibodies directed against ribosomal P proteins: use of a multiple antigen peptide as the coating agent in ELISA

01 Jan 1995

publication

Evidence for an endogenous ouabain-like immunoreactive factor in human newborn plasma coeluted with ouabain on HPLC

01 Dec 1994

publication

An immunodominant epitope in a functional domain near the N-terminus of human granulocyte-macrophage colony-stimulating factor identified by cross-reaction of synthetic peptides with neutralizing anti-protein and anti-peptide antibodies

01 Jul 1993

publication

A little guide for advanced search:

Cancer-on-a-chip model shows that the adenomatous polyposis coli mutation impairs T cell engagement and killing of cancer spheroids

T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations

New publication – The tumor suppressor Adenomatous polyposis coli regulates T lymphocyte migration

The tumor suppressor adenomatous polyposis coli regulates T lymphocyte migration.

Cell Polarity Regulators, Multifunctional Organizers of Lymphocyte Activation and Function.

Coordinating Cytoskeleton and Molecular Traffic in T Cell Migration, Activation, and Effector Functions.

Adenomatous Polyposis Coli Modulates Actin and Microtubule Cytoskeleton at the Immunological Synapse to Tune CTL Functions.

ERM-Dependent Assembly of T Cell Receptor Signaling and Co-stimulatory Molecules on Microvilli prior to Activation.

Histamine releasing factor and elongation factor 1 alpha secreted via malaria parasites extracellular vesicles promote immune evasion by inhibiting specific T cell responses.

Projet de Recherche Clinique : Impact des mutations du gène APC (Adenomatous polyposis coli) dans les réponses immunes anti-tumorales

CoSImmGEn-F : constitution d’une cohorte de sujets atteints de polypose adénomateuse familiale et porteurs d’une mutation du gène APC afin d’étudier le rôle de la génétique du système immunitaire et de l’environnement dans la maladie

HIV-1 Nef Hijacks Lck and Rac1 Endosomal Traffic To Dually Modulate Signaling-Mediated and Actin Cytoskeleton-Mediated T Cell Functions.

Cell Biology of T Cell Receptor Expression and Regulation.

Adenomatous Polyposis Coli Defines Treg Differentiation and Anti-inflammatory Function through Microtubule-Mediated NFAT Localization.

Rab11-FIP3 Regulation of Lck Endosomal Traffic Controls TCR Signal Transduction.

Serine Phosphorylation of SLP76 Is Dispensable for T Cell Development but Modulates Helper T Cell Function.

Think tank: Cancer

Rac1-Rab11-FIP3 regulatory hub coordinates vesicle traffic with actin remodeling and T-cell activation.

Comparative Anatomy of Phagocytic and Immunological Synapses.

Editorial: Molecular Dynamics at the Immunological Synapse.

How the dynamics of signaling complexes at the immunological synapse controls T cell activation

Cytoskeleton, immunological synapse and T cell activation: role of Ezrin and Adenomatous polyposis coli

Immunoregulation

Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation.

Mycolactone impairs T cell homing by suppressing microRNA control of L-selectin expression.

The Shigella flexneri type three secretion system effector IpgD inhibits T cell migration by manipulating host phosphoinositide metabolism.

Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse.

Mycolactone suppresses T cell responsiveness by altering both early signaling and posttranslational events.

Tailoring T-cell receptor signals by proximal negative feedback mechanisms.

A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76.

ZAP-70 kinase regulates HIV cell-to-cell spread and virological synapse formation.

CD8 T cell sensory adaptation dependent on TCR avidity for self-antigens.

Sequence tag scanning: a new explorative strategy for recognition of unexpected protein alterations by nanoelectrospray ionization-tandem mass spectrometry

Large-scale screening for genes involved in T-cell signaling: do we know all the players now?

T-cell receptor-induced phosphorylation of the zeta chain is efficiently promoted by ZAP-70 but not Syk

Proximal changes in signal transduction that modify CD8+ T cell responsiveness in vivo

Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor

In the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern

TCR/CD3 down-modulation and zeta degradation are regulated by ZAP-70.

Tyrosine 315 determines optimal recruitment of ZAP-70 to the T cell antigen receptor.

T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase

Functional dichotomy in natural killer cell signaling: Vav1-dependent and -independent mechanisms

The Rift Valley fever virus nonstructural protein NSs is phosphorylated at serine residues located in casein kinase II consensus motifs in the carboxy-terminus.

Redundant role of the Syk protein tyrosine kinase in mouse NK cell differentiation

Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck.

Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling.

An improved retroviral gene transfer technique demonstrates inhibition of CD4-CD8- thymocyte development by kinase-inactive ZAP-70

Further evidence for an endogenous digitalis-like compound in newborn and adult plasma detected by anti-ouabain antiserum

Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathways.

Binding of human GM-CSF to synthetic peptides of the alpha subunit of its receptor

The stimulatory effect on human erythrocyte rubidium-86 uptake by anti-cardiac-glycoside antibodies

Autoantibodies directed against ribosomal P proteins: use of a multiple antigen peptide as the coating agent in ELISA

Evidence for an endogenous ouabain-like immunoreactive factor in human newborn plasma coeluted with ouabain on HPLC

An immunodominant epitope in a functional domain near the N-terminus of human granulocyte-macrophage colony-stimulating factor identified by cross-reaction of synthetic peptides with neutralizing anti-protein and anti-peptide antibodies

BQ-123 inhibits both endothelin 1 and endothelin 3 mediated C6 rat glioma cell proliferation suggesting an atypical endothelin receptor