Ligne de temps

Uwe Maskos
Responsable de Structure
09 Nov 2020
news

Cocaine addiction: impact of genetic mutations elucidated

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09 Oct 2020
publication

Nicotinic Receptor Subunits Atlas in the Adult Human Lung.

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22 Aug 2020
publication

Alterations in nicotinic receptor alpha5 subunit gene differentially impact early and later stages of cocaine addiction: a translational study in transgenic rats and patients.

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12 Aug 2020
publication

Alterations of specific cortical GABAergic circuits underlie abnormal network activity in a mouse model of Down syndrome.

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07 Aug 2020
publication

A chimeric mouse model to study human iPSC-derived neurons: the case of a truncating SHANK3 mutation.

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29 Jul 2020
publication

Genetic susceptibility to nicotine addiction: Advances and shortcomings in our understanding of the CHRNA5/A3/B4 gene cluster contribution.

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16 Jul 2020
publication

The Constitutive Lack of α7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse.

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08 Jul 2020
publication

The role of the non-neuronal cholinergic system in inflammation and degradation processes in osteoarthritis.

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01 May 2020
publication

Long-term development of human iPSC-derived pyramidal neurons quantified after transplantation into the neonatal mouse cortex.

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22 Apr 2020
publication

β4-Nicotinic Receptors Are Critically Involved in Reward-Related Behaviors and Self-Regulation of Nicotine Reinforcement.

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20 Feb 2020
publication

The nicotinic receptor alpha5 coding polymorphism rs16969968 as a major target in disease: Functional dissection and remaining challenges.

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17 Feb 2020
publication

Muscle Injury Induces Postoperative Cognitive Dysfunction.

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17 Dec 2019
publication

β2* nAChRs on VTA dopamine and GABA neurons separately mediate nicotine aversion and reward.

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30 Oct 2019
publication

A proline-rich motif on VGLUT1 reduces synaptic vesicle super-pool and spontaneous release frequency.

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01 Oct 2019
publication

Microglial production of quinolinic acid as a target and a biomarker of the antidepressant effect of ketamine.

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09 Jul 2019
publication

Profound alteration in reward processing due to a human polymorphism in CHRNA5: a role in alcohol dependence and feeding behavior.

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09 Jul 2019
publication

Profound alteration in reward processing due to a human polymorphism in CHRNA5: a role in alcohol dependence and feeding behavior.

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06 Jul 2019
project

Analysis of human iPSC derived neurons in vivo

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01 Jan 2019
publication

Corticosteroid-Binding Globulin Deficiency Specifically Impairs Contextual and Recognition Memory Consolidation in Male Mice.

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01 Jan 2019
publication

Human Autoantibodies Against N-Methyl-D-Aspartate Receptor Modestly Alter Dopamine D1 Receptor Surface Dynamics.

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27 Nov 2018
publication

Dimethyloxalylglycine preconditioning enhances protective effects of bone marrow-derived mesenchymal stem cells in Aβ- induced Alzheimer disease

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22 Oct 2018
publication

A Human Polymorphism in CHRNA5 Is Linked to Relapse to Nicotine Seeking in Transgenic Rats.

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04 Sep 2018
publication

Manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors.

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01 Sep 2018
publication

iPlasticity: Induced juvenile-like plasticity in the adult brain as a mechanism of antidepressants.

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23 Aug 2018
publication

Induced pluripotent stem cells as a tool to study brain circuits in autism-related disorders

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13 Aug 2018
publication

Gender-specific study of recurrent suicide attempts in outpatients with multiple substance use disorders

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01 Jul 2018
publication

Nicotinic receptors mediate stress-nicotine detrimental interplay via dopamine cells’ activity.

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01 Jun 2018
publication

Positive allosteric modulators of α7* or β2* nicotinic acetylcholine receptors trigger different kinase pathways in mitochondria.

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01 Jun 2018
publication

Relevance of treated cocaine users’ retrospective memory of first cocaine use.

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27 Mar 2018
publication

Nicotinic Acetylcholine Receptors Control Encoding and Retrieval of Associative Recognition Memory through Plasticity in the Medial Prefrontal Cortex

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02 Mar 2018
project

Studying vulnerability to drug addiction: contribution of the nicotinic acetylcholine receptor α5 subunit.

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01 Mar 2018
publication

GluD1, linked to schizophrenia, controls the burst firing of dopamine neurons.

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27 Feb 2018
project

Toxins and nanobodies as subtype-specific ligands and allosteric modulators of nicotinic acetylcholine receptors (PTR Nicobinder)

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24 Jan 2018
project

MECANICOC

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01 Jan 2018
publication

Alpha6-Containing Nicotinic Acetylcholine Receptors Mediate Nicotine-Induced Structural Plasticity in Mouse and Human iPSC-Derived Dopaminergic Neurons.

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01 Jan 2018
publication

Mitochondrial Nicotinic Acetylcholine Receptors Support Liver Cells Viability After Partial Hepatectomy.

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01 Oct 2017
publication

Transcriptome of melanoma cells from two mouse models, Tyr:NRas Q61K and Tyr:Rack1-HA, Tyr:NRas Q61K .

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01 Aug 2017
publication

RACK1 cooperates with NRASQ61K to promote melanoma in vivo.

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02 Mar 2017
news

Cover Image in Aging (Koukouli et al. 2017)

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01 Mar 2017
publication

Nicotine reverses hypofrontality in animal models of addiction and schizophrenia.

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01 Feb 2017
publication

Human polymorphisms in nicotinic receptors: a functional analysis in iPS-derived dopaminergic neurons.

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23 Jan 2017
news

Nicotine reverses hypofrontality in animal models of addiction and schizophrenia

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01 Jan 2017
publication

A novel adjustable automated system for inducing chronic intermittent hypoxia in mice.

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20 Dec 2016
publication

Early and progressive deficit of neuronal activity patterns in a model of local amyloid pathology in mouse prefrontal cortex.

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20 Dec 2016
publication

Nicotinic receptors in mouse prefrontal cortex modulate ultraslow fluctuations related to conscious processing.

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20 Dec 2016
publication

Early and progressive deficit of neuronal activity patterns in a model of local amyloid pathology in mouse prefrontal cortex

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10 Dec 2016
publication

Camelid single-domain antibodies: A versatile tool for in vivo imaging of extracellular and intracellular brain targets.

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01 Oct 2016
publication

A role for β2* nicotinic receptors in a model of local amyloid pathology induced in dentate gyrus.

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01 Sep 2016
publication

Alterations in alpha5* nicotinic acetylcholine receptors result in midbrain- and hippocampus-dependent behavioural and neural impairments.

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01 Aug 2016
publication

Chronic stress does not further exacerbate the abnormal psychoneuroendocrine phenotype of Cbg-deficient male mice.

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01 Jun 2016
publication

Role of β4* Nicotinic Acetylcholine Receptors in the Habenulo-Interpeduncular Pathway in Nicotine Reinforcement in Mice.

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10 May 2016
publication

CNTN6 mutations are risk factors for abnormal auditory sensory perception in autism spectrum disorders

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01 Mar 2016
publication

Nicotinic receptors in the ventral tegmental area promote uncertainty-seeking.

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02 Nov 2015
event

NEUROSCIENCE SEMINAR : Pr. Salah El Mestikawy “Regulation of reward circuits and addiction by VGLUT3 and cholinergic interneurons from the nucleus accumbens”

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15 Oct 2015
publication

The multiple roles of the α7 nicotinic acetylcholine receptor in modulating glutamatergic systems in the normal and diseased nervous system.

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30 Sep 2015
publication

New tools for amyloid plaques detection by MRI: Gadolinium-VHH antibody conjugates

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01 Sep 2015
publication

The nicotinic acetylcholine receptor: From molecular biology to cognition.

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01 Sep 2015
publication

Role of the nicotinic acetylcholine receptor in Alzheimer’s disease pathology and treatment.

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01 Aug 2015
publication

Crucial role of nicotinic α5 subunit variants for Ca2+ fluxes in ventral midbrain neurons.

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03 Jul 2015
project

A Project of Integrative Neurobiology

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01 Jun 2015
publication

EMMPRIN regulates β1 integrin-mediated adhesion through Kindlin-3 in human melanoma cells.

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13 May 2015
publication

The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors

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12 May 2015
publication

High-throughput somatic mutation profiling in pulmonary sarcomatoid carcinomas using the LungCarta™ Panel: exploring therapeutic targets

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11 May 2015
team

Neurobiologie intégrative des systèmes cholinergiques

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01 Jan 2015
publication

EMMPRIN/CD147 is a novel coreceptor of VEGFR-2 mediating its activation by VEGF.

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01 Jan 2015
publication

Differential roles of α6β2* and α4β2* neuronal nicotinic receptors in nicotine- and cocaine-conditioned reward in mice.

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01 Dec 2014
publication

Role of corticosteroid binding globulin in emotional reactivity sex differences in mice.

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17 Sep 2014
department

Neuroscience

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01 Sep 2014
publication

The novel α7β2-nicotinic acetylcholine receptor subtype is expressed in mouse and human basal forebrain: biochemical and pharmacological characterization.

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01 Aug 2014
publication

The α3β4* nicotinic ACh receptor subtype mediates physical dependence to morphine: mouse and human studies

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01 Aug 2014
publication

Nicotine consumption is regulated by a human polymorphism in dopamine neurons.

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01 May 2014
publication

Concomitant alpha7 and beta2 nicotinic AChR subunit deficiency leads to impaired energy homeostasis and increased physical activity in mice.

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01 Jan 2014
publication

VEGF neutralizing aerosol therapy in primary pulmonary adenocarcinoma with K-ras activating-mutations

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11 Sep 2013
publication

Adult neurogenesis produces neurons with unique GABAergic synapses in the olfactory bulb

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29 Mar 2013
publication

Nicotine-induced structural plasticity in mesencephalic dopaminergic neurons is mediated by dopamine D3 receptors and Akt-mTORC1 signaling

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01 Mar 2013
publication

Co-activation of VTA DA and GABA neurons mediates nicotine reinforcement.

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19 Feb 2013
publication

Contribution of α7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure

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10 Jan 2013
publication

Contactin 4, -5 and -6 differentially regulate neuritogenesis while they display identical PTPRG binding sites

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05 Jul 2012
publication

Receptor-type tyrosine phosphatase ligands: looking for the needle in the haystack

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01 May 2012
publication

Modulation of the mouse prefrontal cortex activation by neuronal nicotinic receptors during novelty exploration but not by exploration of a familiar environment.

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28 Mar 2012
publication

Selective re-expression of β2 nicotinic acetylcholine receptor subunits in the ventral tegmental area of the mouse restores intravenous nicotine self-administration

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15 Feb 2012
publication

Striatal α5 nicotinic receptor subunit regulates dopamine transmission in dorsal striatum

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12 Aug 2011
publication

Nicotinic acetylcholine receptor β2 subunits in the medial prefrontal cortex control attention

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01 Jul 2011
publication

Prefrontal nicotinic receptors control novel social interaction between mice.

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29 Jun 2011
publication

Smoke extracts and nicotine, but not tobacco extracts, potentiate firing and burst activity of ventral tegmental area dopaminergic neurons in mice

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12 May 2011
publication

Aversion to nicotine is regulated by the balanced activity of β4 and α5 nicotinic receptor subunits in the medial habenula

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20 Apr 2011
publication

Neuroprotection of midbrain dopamine neurons by nicotine is gated by cytoplasmic Ca2+

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18 Apr 2011
publication

Distinct contributions of nicotinic acetylcholine receptor subunit alpha4 and subunit alpha6 to the reinforcing effects of nicotine

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01 Jan 2011
publication

Antibodies against extracellular domains of α4 and α7 subunits alter the levels of nicotinic receptors in the mouse brain and affect memory: possible relevance to Alzheimer’s pathology

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25 Aug 2010
publication

α-Conotoxin BuIA[T5A;P6O]: a novel ligand that discriminates between α6ß4 and α6ß2 nicotinic acetylcholine receptors and blocks nicotine-stimulated norepinephrine release

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01 Aug 2010
publication

Role of endogenous acetylcholine in the control of the dopaminergic system via nicotinic receptors.

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08 Jun 2010
publication

Peroxisome proliferator-activated receptors-alpha modulate dopamine cell activity through nicotinic receptors

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01 Mar 2010
publication

A versatile system for the neuronal subtype specific expression of lentiviral vectors.

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18 Nov 2009
publication

Functional effects of antibodies against non-neuronal nicotinic acetylcholine receptors

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01 Nov 2009
publication

Effect of the alpha4beta2* nicotinic acetylcholine receptor partial agonist varenicline on dopamine release in beta2 knock-out mice with selective re-expression of the beta2 subunit in the ventral tegmental area

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25 Dec 2008
publication

Regional changes in the cholinergic system in mice lacking monoamine oxidase A

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19 Nov 2008
publication

Crucial role of alpha4 and alpha6 nicotinic acetylcholine receptor subunits from ventral tegmental area in systemic nicotine self-administration.

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01 Nov 2008
publication

Behavioral sequence analysis reveals a novel role for beta2* nicotinic receptors in exploration.

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14 Oct 2008
publication

Interplay of beta2* nicotinic receptors and dopamine pathways in the control of spontaneous locomotion.

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08 Oct 2008
publication

Regional differential effects of chronic nicotine on brain alpha 4-containing and alpha 6-containing receptors

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01 Mar 2008
publication

The cholinergic mesopontine tegmentum is a relatively neglected nicotinic master modulator of the dopaminergic system: relevance to drugs of abuse and pathology.

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10 Jul 2007
publication

Loss of high-affinity nicotinic receptors increases the vulnerability to excitotoxic lesion and decreases the positive effects of an enriched environment

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10 Apr 2007
publication

Evaluating the suitability of nicotinic acetylcholine receptor antibodies for standard immunodetection procedures

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01 Feb 2007
publication

Emerging concepts: novel integration of in vivo approaches to localize the function of nicotinic receptors.

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15 Nov 2006
publication

Nicotine and serotonin in immune regulation and inflammatory processes: a perspective

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29 Sep 2006
publication

Live imaging of neural structure and function by fibred fluorescence microscopy

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15 Jun 2006
publication

Hierarchical control of dopamine neuron-firing patterns by nicotinic receptors.

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01 Jan 2006
publication

Targeted in vivo expression of nicotinic acetylcholine receptors in mouse brain using lentiviral expression vectors.

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01 Jan 2006
publication

Targeted in vivo expression of nicotinic acetylcholine receptors in mouse brain using lentiviral expression vectors.

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20 Jul 2005
publication

Altered map of visual space in the superior colliculus of mice lacking early retinal waves

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07 Jul 2005
publication

Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors.

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10 Dec 2004
publication

5-HT activates ERK MAP kinase in cultured-human peripheral blood mononuclear cells via 5-HT1A receptors

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01 Oct 2003
publication

Neural cells without functional N-Methyl-D-Aspartate (NMDA) receptors contribute extensively to normal postnatal brain development in efficiently generated chimaeric NMDA R1 -/- +/+ mice

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01 Feb 2003
publication

Differential effect of serotonin on cytokine production in lipopolysaccharide-stimulated human peripheral blood mononuclear cells: involvement of 5-hydroxytryptamine2A receptors

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23 Jul 2002
publication

Retrograde trans-synaptic transfer of green fluorescent protein allows the genetic mapping of neuronal circuits in transgenic mice.

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01 Mar 2001
publication

Long-term survival, migration, and differentiation of neural cells without functional NMDA receptors in vivo

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01 Jan 2001
publication

Immunodepression in sepsis and SIRS assessed by ex vivo cytokine production is not a generalized phenomenon: a review

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01 Jan 1999
publication

5-HT1B receptors modulate release of [3H]dopamine from rat striatal synaptosomes

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15 Dec 1998
publication

Molecular, cellular and physiological characteristics of 5-HT-moduline, a novel endogenous modulator of 5-HT1B receptor subtype

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06 Jul 1998
publication

Mapping of 5-HT-moduline binding sites in guinea-pig brain by film and digital autoradiography

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02 Sep 1997
publication

Autoradiographic characterization of [3H]-5-HT-moduline binding sites in rodent brain and their relationship to 5-HT1B receptors

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01 May 1997
publication

The in situ hybridization and immunocytochemistry techniques for characterization of cells expressing specific mRNAs in paraffin-embedded brains

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01 Oct 1996
publication

5-hydroxytryptamine-moduline, a new endogenous cerebral peptide, controls the serotonergic activity via its specific interaction with 5-hydroxytryptamine1B/1D receptors

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01 Mar 1996
publication

Cellular localization of 5-HT1B receptor mRNA in the rat olfactory tubercle: do GABAergic neurons express the 5-HT1B gene?

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29 Dec 1995
publication

Effects of stress on the functional properties of pre- and postsynaptic 5-HT1B receptors in the rat brain

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01 Dec 1995
publication

Production and characterization of an antibody directed against the mouse 5HT1B receptor

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01 Dec 1995
publication

Host-guided migration allows targeted introduction of neurons into the embryonic brain

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30 Jun 1994
publication

Parallel synthesis and analysis of large numbers of related chemical compounds: applications to oligonucleotides

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11 Oct 1993
publication

A study of oligonucleotide reassociation using large arrays of oligonucleotides synthesised on a glass support

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11 May 1993
publication

A novel method for the analysis of multiple sequence variants by hybridisation to oligonucleotides

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11 May 1993
publication

A novel method for the parallel analysis of multiple mutations in multiple samples

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01 May 1993
publication

[Fundamental aspects of molecular biology. The multigene family of 5-HT1 receptors]

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01 Jan 1993
publication

The serotonin 5-HT1B receptor subtype (Htr1b) gene maps to mouse chromosome 9

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01 Aug 1992
publication

Analyzing and comparing nucleic acid sequences by hybridization to arrays of oligonucleotides: evaluation using experimental models

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11 Apr 1992
publication

Parallel analysis of oligodeoxyribonucleotide (oligonucleotide) interactions. I. Analysis of factors influencing oligonucleotide duplex formation

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11 Apr 1992
publication

Oligonucleotide hybridizations on glass supports: a novel linker for oligonucleotide synthesis and hybridization properties of oligonucleotides synthesised in situ

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01 Jan 1992
publication

Molecular cloning of two partial serotonin 5-HT1D receptor sequences in mouse and one in guinea pig

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01 Jan 1992
publication

Inhibition of [3H] gamma-aminobutyric acid release from guinea-pig hippocampal synaptosomes by serotonergic agents

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