Pascale Pescher is a research engineer in the unit ‘Parasitologie moléculaire et signalisation’. She started her career working on host-mycobacteria interactions and since 2006 joined the field of Leishmania research studying the molecular basis of Leishmania donovani virulence. Applying systems-level analyses (genomic, transcriptomic, proteomic, phosphoproteomic and metabolomic) to a physiologically relevant experimental model for Leishmania donovani infection, she investigates how the parasite adapts to its hosts to reveal potential druggable pathways and new bio-markers. She is currently part of two international projects with the aim to study evolutionary adaptation: “Modelling and functional analysis of clonal Evolution in Leishmania – possible role of non-coding RNAs and RNA modification” with partners from Israel, and “H2020 LeiSHield-MATI RISE”, project she is co-coordinating with G. Spaeth and G. Bussotti that implicates Pasteur institutes from the international network and European research institutions. She is co-author of 30 publications including 16 on Leishmania.
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Timeline
Projects
CV
EDUCATION
- 2015 – Expérimentation animale, concepteur de projets
- 2002 – DEPHE, mention très bien, validation Master 2, Sorbonne Paris, France
- 1988 – DPCT biochimie/biologie, CNAM Paris, France
- 1981 – Bac F7 biochimie, Cachan, France
RESEARCH and Professional EXPERIENCE
- 2008-present – Ingénieure de recherche confirmée, Institut Pasteur, Paris, France
- 1983-2008 – Technicienne, Institut Pasteur, Paris, France
SCIENTIFIC ACTIVITIES
- 30 publications, 3 oral presentations and 10 posters in international congresses – Hirsch h index:13
- Co-organization of 2 departmental retreats Co-coordinator of the LeiSHield-MATI – RISE – H-2020 project Reviewer for PLOS Neglected Tropical diseases
TEACHING ACTIVITIES
- 1 thesis (Leishmania virulence) currently in co-supervision
- Teaching in masters formations at the Institut Pasteur
- Teaching/supervision of researchers, Masters and graduate students
ADMINISTRATIVE RESPONSIBILITIES and EXPERTISE
- From 2013 to 2017, member of the COMESP (scientific evaluation committee) of the Institut Pasteur.
- Scientific responsible of the ‘laboratoire de préparation’
- Correspondent for the animal facility
- Since 2014 designer and responsible for animal experimentation for the unit
- Member of the Biomics committee users for the PIV department
- Member of the MSBio committee users
Publications
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2023Leishmania allelic selection during experimental sand fly infection correlates with mutational signatures of oxidative DNA damage., Proc Natl Acad Sci U S A 2023 Mar; 120(10): e2220828120.
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2023Amphotericin B resistance correlates with increased fitness in vitro and in vivo in Leishmania (Mundinia) martiniquensis., Front Microbiol 2023 ; 14(): 1156061.
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2022Experimental evolution links post-transcriptional regulation to Leishmania fitness gain., PLoS Pathog 2022 Mar; 18(3): e1010375.
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2021Genome instability drives epistatic adaptation in the human pathogen Leishmania., Proc Natl Acad Sci U S A 2021 12; 118(51): .
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2020Dynamic imaging reveals surface exposure of virulent Leishmania amastigotes during pyroptosis of infected macrophages., J Cell Sci 2020 06; 134(5): .
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2020SILAC-based quantitative proteomics reveals pleiotropic, phenotypic modulation in primary murine macrophages infected with the protozoan pathogen Leishmania donovani., J Proteomics 2020 02; 213(): 103617.
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2018Stage-specific expression of the proline-alanine transporter in the human pathogen Leishmania, Mol. Biochem. Parasitol. 2018 06;222:1-5.
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2018Reverse Epidemiology: An Experimental Framework to Drive Leishmania Biomarker Discovery in situ by Functional Genetic Screening Using Relevant Animal Models., Front Cell Infect Microbiol 2018 ; 8(): 325.
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2017Haplotype selection as an adaptive mechanism in the protozoan pathogen Leishmania donovani, Nat Ecol Evol 2017 Dec;1(12):1961-1969.
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2017New insights into experimental visceral leishmaniasis: Real-time in vivo imaging of Leishmania donovani virulence, PLoS Negl Trop Dis 2017 09;11(9):e0005924.
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