Christine Clayton – Centre for Molecular Biology of Heidelberg University (ZMBH), Germany
Trypanosoma brucei has six isoforms of the cap-binding translation initiation factor eIF4E, and five eIF4Gs. I will focus on mechanisms by which the different complexes suppress or promote translation initiation. I will also discuss the links between translation initiation, the stimulatory MKT-PBP1 complex, and expression of developmentally regulated surface proteins including the variant surface glycoprotein that is responsible for antigenic variation.
website : https://www.zmbh.uni-heidelberg.de/clayton/default.shtml