Ligne de temps
Hélène Munier-Lehmann
Chef(fe) de Groupe
16 mars 2024
publication
An equine iPSC-based phenotypic screening platform identifies pro- and anti-viral molecules against West Nile virus.
Lire plus01 janv. 2024
publication
A journey into the regulatory secrets of the de novo purine nucleotide biosynthesis.
Lire plus30 sept. 2023
31 août 2023
publication
Modulation of the functional interfaces between retroviral intasomes and the human nucleosome.
Lire plus20 juin 2023
publication
Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMPDHs.
Lire plus07 févr. 2023
publication
Interaction network among de novo purine nucleotide biosynthesis enzymes in Escherichia coli.
Lire plus24 janv. 2023
11 janv. 2023
publication
SigH stress response mediates killing of Mycobacterium tuberculosis by activating nitronaphthofuran prodrugs via induction of Mrx2 expression.
Lire plus11 oct. 2022
publication
Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism.
Lire plus16 févr. 2022
publication
Discovery of bat coronaviruses close to SARS-CoV-2 and infectious for human cells.
Lire plus12 févr. 2022
publication
Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target.
Lire plus05 déc. 2021
publication
Structure-aided optimization of non-nucleoside M. tuberculosis thymidylate kinase inhibitors.
Lire plus24 nov. 2021
event
Thesis Defense: “Biosynthèse des nucléotides puriques chez les bactéries : identification d’un métabolon et exploration de la régulation allostérique d’une enzyme-clé de la voie de novo, l’inosine 5’-monophosphate déshydrogénase” – ANTOINE GEDEON – vendredi 17 décembre
Lire plus21 juil. 2021
publication
SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction.
Lire plus14 janv. 2021
publication
2-((3,5-Dinitrobenzyl)thio)quinazolinones: Potent Antimycobacterial Agents Activated by Deazaflavin (F420)-Dependent Nitroreductase (Ddn).
Lire plus15 nov. 2020
publication
Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents.
Lire plus11 sept. 2020
publication
Identification of antiviral compounds against equid herpesvirus-1 using real-time cell assay screening: efficacy of decitabine and valganciclovir alone or in combination.
Lire plus01 sept. 2020
publication
Synthesis and structure activity relationships of cyanopyridone based anti-tuberculosis agents.
Lire plus22 juin 2020
publication
Replication of Equine arteritis virus is efficiently suppressed by purine and pyrimidine biosynthesis inhibitors.
Lire plus17 juin 2020
publication
1-(1-Arylethylpiperidin-4-yl)thymine Analogs as Antimycobacterial TMPK Inhibitors.
Lire plus30 mai 2020
publication
A real-time cell-binding assay reveals dynamic features of STxB-Gb3 cointernalization and STxB-mediated cargo delivery into cancer cells.
Lire plus01 déc. 2019
publication
1-(Piperidin-3-yl)thymine amides as inhibitors of M. tuberculosis thymidylate kinase.
Lire plus02 févr. 2019
02 janv. 2019
publication
Screening and evaluation of antiviral compounds against Equid alpha-herpesviruses using an impedance-based cellular assay
Lire plus25 mai 2018
publication
A Novel Polyaminocarboxylate Compound To Treat Murine Pulmonary Aspergillosis by Interfering with Zinc Metabolism
Lire plus15 mars 2018
publication
Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors
Lire plus18 janv. 2018
publication
Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic translation initiation factor 4A
Lire plus11 janv. 2018
publication
Synthesis of sulfamide analogues of deoxthymidine monophosphate as potential inhibitors of mycobacterial cell wall biosynthesis
Lire plus23 nov. 2017
publication
Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT
Lire plus28 août 2017
publication
Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis
Lire plus14 août 2017
publication
Original chemical series of pyrimidine biosynthesis inhibitors that boost the antiviral interferon response
Lire plus10 mars 2017
publication
Tetrahydro-2-furanyl-2,4(1H,3H)-pyrimidinedione derivatives as novel antibacterial compounds against Mycobacterium
Lire plus24 août 2016
publication
Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents
Lire plus11 juil. 2016
publication
Administration of zinc chelators improves survival of mice infected with Aspergillus fumigatus both in monotherapy and in combination with caspofungin.
Lire plus15 mai 2016
01 janv. 2016
publication
Respiratory syncytial virus infection in macaques is not suppressed by intranasal sprays of pyrimidine biosynthesis inhibitors
Lire plus01 janv. 2016
publication
Synthesis and evaluation of original bioisosteres of bacterial type IIA topoisomerases inhibitors
Lire plus16 oct. 2015
17 sept. 2015
project
Interferon induction, inflammation and stress in HCV infection and stress-related pathologies
Lire plus10 sept. 2015
event
Workshop on protein-protein interactions: from low to high-throughput investigations
Lire plus07 sept. 2015
project
FP7 Targeting the Leishmania kinome for the development of novel anti-parasitic strategies (LeishDrug)
Lire plus03 sept. 2015
25 août 2015
publication
Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation
Lire plus20 août 2015
28 juil. 2015
project
ATPase inhibitors, the cases of human heat shock protein 90 and bacterial type IIA topoisomerases
Lire plus28 juil. 2015
22 juil. 2015
22 juil. 2015
16 juil. 2015
30 juin 2015
publication
Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)
Lire plus06 janv. 2015
publication
Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH)
Lire plus05 mai 2014
publication
High-throughput screening for broad-spectrum chemical inhibitors of RNA viruses
Lire plus03 oct. 2013
publication
Inhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunity
Lire plus03 sept. 2013
publication
AutomiG, a biosensor to detect alterations in miRNA biogenesis and in small RNA silencing guided by perfect target complementarity
Lire plus20 mars 2013
01 févr. 2013
publication
Synergy of the antibiotic colistin with echinocandin antifungals in Candida species
Lire plus05 nov. 2012
publication
Synthesis and evaluation of 5′-modified thymidines and 5-hydroxymethyl-2′-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors
Lire plus14 sept. 2012
publication
A phenotypic assay to identify Chikungunya virus inhibitors targeting the nonstructural protein nsP2
Lire plus05 mars 2012
publication
The composition of the culture medium influences the β-1,3-glucan metabolism of Aspergillus fumigatus and the antifungal activity of inhibitors of β-1,3-glucan synthesis
Lire plus01 mars 2012
publication
Synthesis and evaluation of 6-aza-2′-deoxyuridine monophosphate analogs as inhibitors of thymidylate synthases, and as substrates or inhibitors of thymidine monophosphate kinase in Mycobacterium tuberculosis
Lire plus01 janv. 2012
publication
Drug design and identification of potent leads against mycobacterium tuberculosis thymidine monophosphate kinase
Lire plus18 oct. 2011
publication
Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase
Lire plus10 déc. 2010
publication
Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation
Lire plus15 oct. 2010
publication
Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone
Lire plus23 juil. 2009
publication
Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase
Lire plus03 oct. 2008
publication
Metalloprotease vsm is the major determinant of toxicity for extracellular products of Vibrio splendidus
Lire plus01 juil. 2008
publication
Exploring acyclic nucleoside analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase
Lire plus25 avr. 2008
publication
Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity
Lire plus01 avr. 2008
publication
Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position
Lire plus02 oct. 2007
publication
Rational design of 5′-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth
Lire plus03 juin 2007
publication
Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase
Lire plus01 janv. 2007
publication
A new family of inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase
Lire plus01 oct. 2006
publication
Synthesis and biological evaluation of bicyclic nucleosides as inhibitors of M. tuberculosis thymidylate kinase
Lire plus01 août 2006
publication
Multiple microfermentor battery: a versatile tool for use with automated parallel cultures of microorganisms producing recombinant proteins and for optimization of cultivation protocols
Lire plus02 mai 2006
publication
The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer.
Lire plus01 févr. 2006
publication
Unique GMP-binding site in Mycobacterium tuberculosis guanosine monophosphate kinase
Lire plus01 avr. 2005
11 janv. 2005
publication
The crystal structure of Mycobacterium tuberculosis thymidylate kinase in complex with 3′-azidodeoxythymidine monophosphate suggests a mechanism for competitive inhibition
Lire plus01 déc. 2004
publication
Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase
Lire plus01 déc. 2004
publication
High-level production of recombinant sulfide-reactive hemoglobin I from Lucina pectinata in Escherichia coli. High yields of fully functional holoprotein synthesis in the BLi5 E. coli strain
Lire plus01 févr. 2004
publication
Insight into the activation mechanism of Bordetella pertussis adenylate cyclase by calmodulin using fluorescence spectroscopy
Lire plus13 janv. 2004
publication
Structural and dynamic studies on ligand-free adenylate kinase from Mycobacterium tuberculosis revealed a closed conformation that can be related to the reduced catalytic activity
Lire plus15 sept. 2003
publication
Thymidine and thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase
Lire plus28 août 2003
publication
3′-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase
Lire plus01 août 2003
publication
Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans
Lire plus01 août 2003
publication
Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors: Biological evaluation and conformational analysis of 2 ‘- and 3 ‘-modified thymidine analogues
Lire plus15 juil. 2003
publication
Relationship between bacterial virulence and nucleotide metabolism: a mutation in the adenylate kinase gene renders Yersinia pestis avirulent
Lire plus01 mai 2003
publication
Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors
Lire plus11 avr. 2003
publication
Mycobacterium tuberculosis thymidylate kinase: structural studies of intermediates along the reaction pathway
Lire plus01 avr. 2003
01 févr. 2003
publication
Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism
Lire plus01 oct. 2002
publication
Synthesis and evaluation of thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase
Lire plus01 juin 2002
publication
Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods
Lire plus01 févr. 2002
publication
Sugar specificity of bacterial CMP kinases as revealed by crystal structures and mutagenesis of Escherichia coli enzyme
Lire plus01 janv. 2002
publication
Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications
Lire plus01 août 2001
publication
X-ray structure of TMP kinase from Mycobacterium tuberculosis complexed with TMP at 1.95 A resolution
Lire plus01 juin 2001
publication
Thymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymes
Lire plus01 janv. 2001
publication
1H, 13C and 15N resonance assignment and secondary structure of Mycobacterium tuberculosis adenylate kinase
Lire plus01 févr. 2000
publication
Crystallization and preliminary X-ray analysis of the thymidylate kinase from Mycobacterium tuberculosis
Lire plus01 août 1999
publication
A new subfamily of short bacterial adenylate kinases with the Mycobacterium tuberculosis enzyme as a model: A predictive and experimental study
Lire plus21 juin 1996
publication
Re-expression of the mannose 6-phosphate receptors in receptor-deficient fibroblasts. Complementary function of the two mannose 6-phosphate receptors in lysosomal enzyme targeting.
Lire plus26 janv. 1996
publication
A casein kinase II phosphorylation site in the cytoplasmic domain of the cation-dependent mannose 6-phosphate receptor determines the high affinity interaction of the AP-1 Golgi assembly proteins with membranes.
Lire plus01 août 1994
publication
Differential sorting of lysosomal enzymes in mannose 6-phosphate receptor-deficient fibroblasts.
Lire plus15 déc. 1993
publication
Structural and physico-chemical characteristics of Bordetella pertussis adenylate kinase, a tryptophan-containing enzyme.
Lire plus15 oct. 1993
publication
Structural flexibility of the calmodulin-binding locus in Bordetella pertussis adenylate cyclase. Reconstitution of catalytically active species from fragments or inactive forms of the enzyme.
Lire plus25 janv. 1993
publication
Characterization of a synthetic calmodulin-binding peptide derived from Bacillus anthracis adenylate cyclase.
Lire plus25 janv. 1993
publication
Cooperative phenomena in binding and activation of Bordetella pertussis adenylate cyclase by calmodulin.
Lire plus15 mai 1992
publication
The role of histidine 63 in the catalytic mechanism of Bordetella pertussis adenylate cyclase.
Lire plus14 janv. 1992
publication
1H and 15N NMR characterization of free and bound states of an amphiphilic peptide interacting with calmodulin.
Lire plus01 juil. 1991
publication
Functional consequences of single amino acid substitutions in calmodulin-activated adenylate cyclase of Bordetella pertussis.
Lire plus14 mars 1991
publication
Isolation and characterization of catalytic and calmodulin-binding domains of Bordetella pertussis adenylate cyclase.
Lire plus04 sept. 1990
publication