Timeline

Hélène Munier-Lehmann
Group Leader
11 Sep 2020
publication

Identification of antiviral compounds against equid herpesvirus-1 using real-time cell assay screening: efficacy of decitabine and valganciclovir alone or in combination.

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01 Sep 2020
publication

Synthesis and structure activity relationships of cyanopyridone based anti-tuberculosis agents.

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22 Jun 2020
publication

Replication of Equine arteritis virus is efficiently suppressed by purine and pyrimidine biosynthesis inhibitors.

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17 Jun 2020
publication

1-(1-Arylethylpiperidin-4-yl)thymine Analogs as Antimycobacterial TMPK Inhibitors.

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30 May 2020
publication

A real-time cell-binding assay reveals dynamic features of STxB-Gb3 cointernalization and STxB-mediated cargo delivery into cancer cells.

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01 Dec 2019
publication

1-(Piperidin-3-yl)thymine amides as inhibitors of M. tuberculosis thymidylate kinase.

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02 Feb 2019
publication

First-in-class allosteric inhibitors of bacterial IMPDHs

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02 Jan 2019
team

Organic Chemistry

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02 Jan 2019
publication

Screening and evaluation of antiviral compounds against Equid alpha-herpesviruses using an impedance-based cellular assay

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25 May 2018
publication

A Novel Polyaminocarboxylate Compound To Treat Murine Pulmonary Aspergillosis by Interfering with Zinc Metabolism

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15 Mar 2018
publication

Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors

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18 Jan 2018
publication

Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic translation initiation factor 4A

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11 Jan 2018
publication

Synthesis of sulfamide analogues of deoxthymidine monophosphate as potential inhibitors of mycobacterial cell wall biosynthesis

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23 Nov 2017
publication

Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT

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28 Aug 2017
publication

Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis

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14 Aug 2017
publication

Original chemical series of pyrimidine biosynthesis inhibitors that boost the antiviral interferon response

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31 May 2017
publication

Identification of a small molecule that primes the type I interferon response to cytosolic DNA

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10 Mar 2017
publication

Tetrahydro-2-furanyl-2,4(1H,3H)-pyrimidinedione derivatives as novel antibacterial compounds against Mycobacterium

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24 Aug 2016
publication

Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents

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11 Jul 2016
publication

Administration of zinc chelators improves survival of mice infected with Aspergillus fumigatus both in monotherapy and in combination with caspofungin.

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15 May 2016
publication

Anti-mycobacterial activity of thymine derivatives bearing boron clusters

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01 Jan 2016
publication

Synthesis and evaluation of original bioisosteres of bacterial type IIA topoisomerases inhibitors

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01 Jan 2016
publication

Respiratory syncytial virus infection in macaques is not suppressed by intranasal sprays of pyrimidine biosynthesis inhibitors

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14 Dec 2015
publication

The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components

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16 Oct 2015
project

AEGIS (Accelerated Early staGe drug dIScovery)

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17 Sep 2015
project

Interferon induction, inflammation and stress in HCV infection and stress-related pathologies

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10 Sep 2015
event

Workshop on protein-protein interactions: from low to high-throughput investigations

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07 Sep 2015
project

FP7 Targeting the Leishmania kinome for the development of novel anti-parasitic strategies (LeishDrug)

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03 Sep 2015
project

Inhibitors of Pseudomonas aeruginosa IMPDH

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25 Aug 2015
publication

Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation

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20 Aug 2015
project

Inhibitors of TMPK from Mycobacterium tuberculosis

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28 Jul 2015
project

ATPase inhibitors, the cases of human heat shock protein 90 and bacterial type IIA topoisomerases

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28 Jul 2015
project

Alkoxypyrazoles, inhibitors of dihydroorotate dehydrogenase (DHODH)

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22 Jul 2015
project

Inosine-5′-monophosphate dehydrogenase

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22 Jul 2015
project

Nucleoside monophosphate kinases (NMPKs)

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16 Jul 2015
team

Group: Biochemistry and screening

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30 Jun 2015
publication

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

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11 May 2015
team

Chemistry and Biocatalysis

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06 Feb 2015
publication

[Stimulation of the antiviral innate immune response by pyrimidine biosynthesis inhibitors: a surprise of phenotypic screening]

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06 Jan 2015
publication

Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH)

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05 May 2014
publication

High-throughput screening for broad-spectrum chemical inhibitors of RNA viruses

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03 Oct 2013
publication

Inhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunity

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03 Sep 2013
publication

AutomiG, a biosensor to detect alterations in miRNA biogenesis and in small RNA silencing guided by perfect target complementarity

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20 Mar 2013
publication

On dihydroorotate dehydrogenases and their inhibitors and uses

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01 Feb 2013
publication

Synergy of the antibiotic colistin with echinocandin antifungals in Candida species

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05 Nov 2012
publication

Synthesis and evaluation of 5′-modified thymidines and 5-hydroxymethyl-2′-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors

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14 Sep 2012
publication

A phenotypic assay to identify Chikungunya virus inhibitors targeting the nonstructural protein nsP2

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05 Mar 2012
publication

The composition of the culture medium influences the β-1,3-glucan metabolism of Aspergillus fumigatus and the antifungal activity of inhibitors of β-1,3-glucan synthesis

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01 Mar 2012
publication

Synthesis and evaluation of 6-aza-2′-deoxyuridine monophosphate analogs as inhibitors of thymidylate synthases, and as substrates or inhibitors of thymidine monophosphate kinase in Mycobacterium tuberculosis

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01 Jan 2012
publication

Drug design and identification of potent leads against mycobacterium tuberculosis thymidine monophosphate kinase

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18 Oct 2011
publication

Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase

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10 Dec 2010
publication

Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation

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15 Oct 2010
publication

Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone

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23 Jul 2009
publication

Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase

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03 Oct 2008
publication

Metalloprotease vsm is the major determinant of toxicity for extracellular products of Vibrio splendidus

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01 Jul 2008
publication

Exploring acyclic nucleoside analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase

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25 Apr 2008
publication

Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity

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01 Apr 2008
publication

Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position

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02 Oct 2007
publication

Rational design of 5′-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth

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03 Jun 2007
publication

Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase

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01 Jan 2007
publication

A new family of inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

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01 Oct 2006
publication

Synthesis and biological evaluation of bicyclic nucleosides as inhibitors of M. tuberculosis thymidylate kinase

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01 Aug 2006
publication

Multiple microfermentor battery: a versatile tool for use with automated parallel cultures of microorganisms producing recombinant proteins and for optimization of cultivation protocols

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02 May 2006
publication

The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer

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01 Feb 2006
publication

Unique GMP-binding site in Mycobacterium tuberculosis guanosine monophosphate kinase

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01 Apr 2005
publication

LEA3D: a computer-aided ligand design for structure-based drug design

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11 Jan 2005
publication

The crystal structure of Mycobacterium tuberculosis thymidylate kinase in complex with 3′-azidodeoxythymidine monophosphate suggests a mechanism for competitive inhibition

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01 Dec 2004
publication

Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

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01 Dec 2004
publication

High-level production of recombinant sulfide-reactive hemoglobin I from Lucina pectinata in Escherichia coli. High yields of fully functional holoprotein synthesis in the BLi5 E. coli strain

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01 Feb 2004
publication

Insight into the activation mechanism of Bordetella pertussis adenylate cyclase by calmodulin using fluorescence spectroscopy

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13 Jan 2004
publication

Structural and dynamic studies on ligand-free adenylate kinase from Mycobacterium tuberculosis revealed a closed conformation that can be related to the reduced catalytic activity

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15 Sep 2003
publication

Thymidine and thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase

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28 Aug 2003
publication

3′-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

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01 Aug 2003
publication

Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors: Biological evaluation and conformational analysis of 2 ‘- and 3 ‘-modified thymidine analogues

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01 Aug 2003
publication

Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans

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15 Jul 2003
publication

Relationship between bacterial virulence and nucleotide metabolism: a mutation in the adenylate kinase gene renders Yersinia pestis avirulent

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01 May 2003
publication

Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors

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11 Apr 2003
publication

Mycobacterium tuberculosis thymidylate kinase: structural studies of intermediates along the reaction pathway

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01 Apr 2003
publication

Reaction of human UMP-CMP kinase with natural and analog substrates

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25 Nov 2002
publication

Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism

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01 Oct 2002
publication

Synthesis and evaluation of thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase

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01 Jun 2002
publication

Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods

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01 Feb 2002
publication

Sugar specificity of bacterial CMP kinases as revealed by crystal structures and mutagenesis of Escherichia coli enzyme

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01 Jan 2002
publication

Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications

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01 Aug 2001
publication

X-ray structure of TMP kinase from Mycobacterium tuberculosis complexed with TMP at 1.95 A resolution

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01 Jun 2001
publication

Thymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymes

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01 Jan 2001
publication

1H, 13C and 15N resonance assignment and secondary structure of Mycobacterium tuberculosis adenylate kinase

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01 Feb 2000
publication

Crystallization and preliminary X-ray analysis of the thymidylate kinase from Mycobacterium tuberculosis

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01 Aug 1999
publication

A new subfamily of short bacterial adenylate kinases with the Mycobacterium tuberculosis enzyme as a model: A predictive and experimental study

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