Bacterial strain nomenclatures applied to international epidemiological surveillance: A Theoretical and Hands-on Course
This two-day course will provide participants both theory and hands-on practical exercises on bacterial strain nomenclatures using the core genome MLST concept. Focus will be put on the BIGSdb software tool and database and […]
INCEPTION – INstitut Convergences pour l’étude de l’Émergence des Pathologies au Travers des Individus et des populatiONs et des
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PIBnet – Pasteur International Bioresources network
PIBnet est un grand projet dont l’objectif est d’harmoniser, d’optimiser et de valoriser les collections de micro-organismes et les méthodes d’analyses au sein des laboratoires experts à Paris et dans le Réseau International des […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation Le but du projet Biologie Intégrative des Maladies Infectieuses Emergentes (IBEID), coordonné par les professeurs Philippe Sansonetti et Pascale Cossart, est de développer une structure pour anticiper et lutter contre les maladies […]
Rapid diagnostic test of diphtheria
Although the crucial role of diphtheria toxin in severe diphtheria symptoms was discovered more than 100 years ago by Yersin and Roux, a reliable, specific, accurate, affordable and simple method for the detection of […]
Oxford Nanopore sequencing for detection and surveillance of pathogens
This project intends to share expertise, developments, equipement and bioinformatics tools to apply Oxford Nanopore Technology sequencing to the detection, diagnostic and characterization of pathogens of public health importance. It corresponds to a collaboration […]
KlebNet: a One Health network bridging science and surveillance on antimicrobial resistant Klebsiella
Klebsiella, particularly Klebsiella pneumoniae (hereafter, collectively called Kp) is an opportunistic pathogen of humans and animals that now tops the ‘urgent threat’ lists of CDC, ECDC and WHO due to high rates of multidrug […]
MedVetKlebs: Klebsiella pneumoniae from ecology to source attribution and transmission control
Klebsiella pneumoniae (hereafter, K. pneumoniae) is a major cause of hospital-acquired infections such as urinary infections, pneumonia, bloodstream infections, infections in newborns and in intensive-care unit patients. Some hypervirulent strains also cause community infections […]
SPARK: Transmission of multidrug resistant Klebsiella clones and genes – a One Health approach
The SPARK (Spread of Population-wide Antibiotic Resistance in Klebsiella) project, funded by the JPIAMR instrument of the European Union H2020 programme, seeks to address the complex issue of transmission of antimicrobial resistance genes and […]
Bordetella and whooping cough: Population Biology and Vaccination
Our research on Bordetella covers the population biology and epidemiology of various Bordetella species, including B. pertussis, the major agent of whooping cough; vaccine improvements; and the impact of vaccination on population evolution. Current […]
Diphtheria and Corynebacteria: genomics, evolution and epidemiology
Our project on Corynebacterium diphtheriae and related bacterial pathogenic species aims at defining the diversity, evolution and epidemiology of the agents of diphtheria. We study clinical isolates from our culture collection of prospectively collected […]
Population biology of the bacterial pathogen Klebsiella pneumoniae
Klebsiella pneumoniae is one of the most urgent threats to public health given its increasing resistance to antimicrobial agents including carbapenems, considered as last-resort antibiotics. In this project we aim to understand the ecological, epidemiological and […]
Genomic databases for bacterial epidemiology, population biology and strain nomenclature
High-throughput sequencing has revolutionized our abilities to track and characterize novel bacterial strains as they emerge and disseminate globally. Genome-based typing systems are being developed to replace or complement classical epidemiological markers and have […]
Bioinformatics developments for whole-genome sequencing of microbial agents for epidemiological surveillance
The PIBnet initiative is a large collaborative program that aims at reinforcing microbial strain collection management and characterization approaches and technologies. It involves National Reference Centers, WHO-collaborative centers, biological resources centers and other microbiological expertise laboratories, together […]
Human and ruminant neurolisteriosis: a comparative study (Swiss National Science Foundation, Sinergia)
Neurolisteriosis is a common and frequently fatal complication of Listeria monocytogenes infection in human and ruminants. It has a high impact on human and animal health, but only little is known about its pathogenesis. […]
Contaminant oligonucleotide sequences such as primers and adapters can occur in both ends of high-throughput sequencing (HTS) reads. AlienTrimmer was developed in order to detect and remove such contaminants. Based on the decomposition of […]
Genomic and nomenclature databases of pathogenic bacterial strains
The genomic and nomenclature databases of strains of pathogenic bacterial species are available through the Institut Pasteur BIGSdb portal: http://bigsdb.pasteur.fr. The portal is powered by the Bacterial Isolates Genome Sequence DataBase (BIGSdb) tool developed […]
2019Improved quadruplex real-time PCR assay for the diagnosis of diphtheria, J. Med. Microbiol. 2019 Sep;.
2019Genome characteristics of isolates from Tunisia, J. Med. Microbiol. 2019 Sep;68(9):1320-1323.
2019Author Correction: Hypervirulent Listeria monocytogenes clones’ adaptation to mammalian gut accounts for their association with dairy products, Nat Commun 2019 Aug;10(1):3619.
2019The speciation and hybridization history of the genus, Microb Genom 2019 Aug;5(8).
2019An MLST approach to support tracking of plasmids carrying OXA-48-like carbapenemase, J. Antimicrob. Chemother. 2019 Jul;74(7):1856-1862.
2019Detection of OXA-48-like-producing Enterobacterales in Irish recreational water, Sci. Total Environ. 2019 Nov;690:1-6.
2019Hypervirulent Listeria monocytogenes clones’ adaption to mammalian gut accounts for their association with dairy products, Nat Commun 2019 06;10(1):2488.
2019New Bacteriophages against Emerging Lineages ST23 and ST258 of and Efficacy Assessment in Larvae, Viruses 2019 May;11(5).
2019Comparative Analysis of the Two Multilocus Sequence Typing (MLST) Schemes, Front Microbiol 2019;10:930.
2019Genus-wide Leptospira core genome multilocus sequence typing for strain taxonomy and global surveillance, PLoS Negl Trop Dis 2019 Apr;13(4):e0007374.
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