Présentation
The Group for AIDS Research (Groupe de Réflexion SIDA, GRS) organizes bimonthly meetings and seminars around an HIV / AIDS research topic.
Meetings and seminars are open to all. Meetings are usually held on Tuesdays at 4 p.m. in room 14 of the Lwoff building, Pasteur Institute, Paris.
The GRS meetings and seminars are organized with the support of ANRS.
The next GRS seminar will be given on Tuesday June 23, 2019, at noon, by Michael MALIM, Professor at King’s College, London. Pr. Malim will discuss recent advances in the field of HIV restriction factors. The seminar will be co-organized by Olivier Schwartz (Virus and Immunity Unit, Institut Pasteur) and Lisa Chakrabarti (for the GRS).
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Missions of the GRS
Objective n° 1
To further discussion and information exchange on the theme of HIV / AIDS research at the Pasteur Institute of Paris
The GRS is an interdisciplinary group of researchers involved in HIV / AIDS research at the Pasteur Institute of Paris. The GRS also involves members of other institutions such as ANRS and AP-HP in its organization. The GRS aims at improving scientific communication on HIV / AIDS and at providing information on teams involved in HIV research on the campus.
The GRS organizes a monthly meeting around and HIV / AIDS thematic that concerns fundamental research ( Retrovirology, Pathogenesis) or applied research (Vaccinology, Antiretrovirals, Immunotherapy, …).
Objective n° 2
To exchange informations and further collaborations with researchers of the International Network of Pasteur Institutes involved in HIV / AIDS research
These actions are lead in concert with the relevant directions at the Pasteur Institute. Information on GRS meetings and HIV / AIDS research at the Pasteur Institutes are posted online to facilitate the involvement of all members of the network. Special meetings are organized by the GRS upon the visit of network researchers on the Parisian campus.
Objective n° 3
To promote research and public health actions in the field of HIV / AIDS
The GRS contributes to the identification of common research themes to be developed at the Pasteur Institutes, and to the setup of collaborative programs such as PTR (Programmes Transversaux de Recherche) in the field of HIV / AIDS.
The GRS organizes a scientific watch in the field of HIV / AIDS and promotes the discussion of current HIV / AIDS topics at its monthly meetings.
Organization of the GRS
Organizing committee:
- Nicoletta Casartelli, Virus and Immunity Unit, Pasteur Institute
- Lisa Chakrabarti, Virus and Immunity Unit, CIVIC Group, Pasteur Institute
- Arnaud Moris, CIMI, Pierre and Marie Curie University, Pitié-Salpêtrière, Paris
- Hugo Mouquet, Humoral Response to Pathogens Group, Pasteur Institute
- Livia Pedroza-Martins, National Agency for AIDS and Viral Hepatitis Research (ANRS)
- Asier Saez-Cirion, HIV, Inflammation, and Persistence Unit, Pasteur Institute.
Advisers
- Fernando Arenzana-Seisdedos, Shanghai Pasteur Institute
- Françoise Barré-Sinoussi, International Direction, Pasteur Institute.
- Pierre Charneau, Molecular Virology and Vaccinology Unit, Pasteur Institute
- Michaela Müller-Trutwin, HIV, Inflammation, and Persistence Unit, Pasteur Institute
- Olivier Schwartz, Virus and Immunity Unit, Pasteur Institute
- Frédéric Tangy, Viral Genomic and Vaccination Unit, Pasteur Institute
- Simon Wain-Hobson, Molecular Retrovirology Unit, Pasteur Institute.
Organization of GRS meetings
GRS meetings are held in general on the second Tuesday of the month. Meetings last for two hours and are organized around two to three presentations and a discussion. Invited speakers may be any researcher working in the field of HIV / AIDS, on the campus or in other institutions.
The topic of each meeting is chosen for its current interest and importance, independently of its representation on the campus. The topic does not necessarily concern HIV / AIDS in the strict sense, but may be chosen to broaden our perspective on HIV / AIDS research. Possible topics and speaker names can be proposed to the organization committee.
For each meeting, the organization committee invites two to three speakers that work at the Pasteur Institutes or in exterior organizations (INSERM, CNRS, hospitals of the AP-HP, members of coordinated actions of the ANRS, the National Agency for AIDS Research, …). Presentations are followed by a discussion, which is moderated by a researcher with authority in the field, but who does not necessarily work on HIV / AIDS.
GRS meetings are announced by posters on the Paris campus and are listed on the Conference page of the Pasteur Institute web site.
Past GRS Meetings
GRS Meetings 2019
| Meeting number | 102 |
| Date | 28/05/2019 at 4 PM |
| Topic | Mechanisms of HIV antigen presentation |
| Organizer | Arnaud Moris Institute for Integrative Biology of the Cell, Gif sur Yvette, France |
| Speakers | Persephone BORROW Nuffield Department of Medicine, Oxford university, UK Identification of novel targets for HIV-specific CD8+ T cells on HIV-infected cells |
| Sylvie LE GALL Ragon Institute, Cambridge, USA Antigen processing and presentation in HIV infection |
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| Arnaud MORIS Institute for Integrative Biology of the Cell, Gif sur Yvette, France From CTL to the HIV translatome |
| Meeting number | 101 |
| Date | 16/04/2019 at noon |
| Topic | GRS International Seminar Series: Virology |
| Organizer | Lisa Chakrabarti and Olivier Schwartz (Virus and Immunity Unit, Pasteur Institute, Paris) |
| Speaker | Alexandra TRKOLA Institute for Medical Virology, University of Zürich, Switzeland Determinants of HIV-1 broadly neutralizing antibody induction |
| Meeting number | 100 |
| Date | 19/03/2019 at 4 PM |
| Topic | Mechanisms of restriction of viral entry |
| Organizer | Nicoletta CASARTELLI Virtus and Immunity Unit, Institut Pasteur, Paris |
| Speakers | Julian BUCHRIESER Virus and Immunity Unit, Institut Pasteur, Paris Mechanisms of restriction of viral entry: an introduction |
| Anna KAJASTE-RUDNITSKI San Raffaele Telethon Institute for Gene Therapy, Milan, Italy Insight into HIV restriction from improving haematopoietic stem cell gene therapy |
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| Christine GOFFINET Charité – Universitätsmedizin Berlin, Germany Endogenous SERINC5 is modulated by type I IFN and antagonized by HIV-1 Nef despite incorporation into virions |
| Meeting number | 99 |
| Date | 29/01/2019 at noon |
| Topic | GRS International Seminar Series: Virology |
| Organizer | Nicoletta Casartelli (Virus and Immunity Unit, Pasteur Institute, Paris) |
| Speaker | Oliver FACKLER Department of Infectious Diseases, Integrative Virology, University Hospital Heidelberg, Germany Tissue-like 3D environment shape modes of HIV-spread |
GRS Meetings 2018
| Meeting number | 98 |
| Date | 10/10/2018 at 5 PM |
| Topic | GRS International Seminar Series: Immunology |
| Organizer | Olivier Schwartz / Lisa Chakrabarti (Virus and Immunity Unit, Pasteur Institute, Paris) |
| Speaker | Galit ALTER Ragon Institute, Massachusetts General Hospital, Cambridge, USA Defining Correlates of Immunology Using Systems Serology |
| Meeting number | 97 |
| Date | 12/06/2018 at 4 PM |
| Topic | Humanized mouse models for HIV studies |
| Organizer | Hugo Mouquet (Humoral response to Pathogens Unit) and Lisa Chakrabarti (Virus and Immunity Unit), Pasteur Institute, Paris. |
| Speakers | Guillemette MASSE-RANSON Innate Immunity Unit, Pasteur Institute, Paris Combining immunotherapies in HIV-infected Human Immune System (HIS) mice |
| Yu Chun LONE Lwoff Institute, Paris South University and INSERM UMR1197, Villejuif Recent development of a new preclinical model, “Humamice”, for exploring human cellular immunity |
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| Véronique GODOT CHU Henri Mondor, INSERM U955, Vaccine Research Institute, Créteil A prophylactic vaccine targeting HIV-1 Env to human CD40 elicits Env-specific IgG+ B cells and memory Tfh cells |
| Meeting number | 96 |
| Date | 13/03/2018 at 4 PM |
| Topic | Immune reconstitution in HIV infection |
| Organizer | Jade Ghosn (UF de Thérapeutique en Immuno-Infectiologie, Hôtel Dieu, Paris) |
| Speakers | Dominique COSTAGLIOLA INSERM, Sorbonne Université, Institut Pierre Louis d’Epidémiologie et de Santé Publique, Paris Immune restauration in HIV-infected patients who initiated antiretroviral therapy between 2006 and 2014: data from the FHDH-ANRS CO4 cohort |
| Rémi CHEYNIER Equipe Cytokines et Infections Virales, Institut Cochin, Paris Role of IL-7 to promote immunbe reconstitution and stimulate vaccine responses: studies in simian models |
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| Jacques GASNAULT UF des Maladies Neurovirales, CHU Bicêtre; IMVA INSERM U1184, Université Paris-Sud Immunotherapy with IL-7 in progressive multifocal leukoencephalopathy (PML) associated to CD4+ T cell lymphopenia |
| Meeting number | 95 |
| Date | 16/02/2018 at 4 PM |
| Topic | Metabolism and HIV |
| Organizer | Asier Saez-Cirion (Unité HIV, Inflammation, et Persistance, Pasteur Institute, Paris) |
| Speakers | Mireille LAFORGE UFR Biomédicale, Université Paris Descartes Impact of mitochondrial morphogenesis on the energetic metabolism of CD4+ T cells in AIDS |
| Jose Carlos VALLE CASUSO Unité HIV, Inflammation, et Persistance, Institut Pasteur, Paris Role of CD4+ T cell metabolism in establishment and persistence of the HIV reservoir |
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| Jacqueline CAPEAU Centre de Recherche Saint-Antoine, Inserm U938-UPMC, Hôpital Tenon AP-HP Metabolic complications in HIV-infected patients |
GRS Meetings 2017
| Meeting number | 94 |
| Date | 21/11/2017 at 4 PM |
| Topic | HIV vaccination strategies |
| Organizer | Lisa Chakrabarti (Viral Pathogenesis Unit, Pasteur Institute, Paris) |
| Speakers | Frédéric TANGY
Unité de Génomique Virale et Vaccination, Institut Pasteur, Paris
Protective efficacy of live measles-HIV vaccine against SHIV-SF162P3 challenges in cynomolgus macaques
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Stéphane PAUL
Groupe d’Immunité des Muqueuses et Agents Pathogènes/EA3064, INSERM CIE3 1408 Vaccinology, Université de Lyon, Saint-Etienne Use of SIgA for HIV mucosal vaccination
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Pierre CHARNEAU
Unité de Virologie Moléculaire et Vaccinologie, Institut Pasteur, Paris Lentiviral vectors as T-Cell vaccines
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| Meeting number | 93 |
| Date | 27/06/2017 at 4 PM |
| Topic | Meeting in memory of Mark Wainberg |
| Organizer | Lisa Chakrabarti (Viral Pathogenesis Unit, Pasteur Institute, Paris) |
| Speakers | Françoise BARRE-SINOUSSI Direction Internationale, Institut Pasteur, Paris Introduction |
| Christian BRECHOT Directeur Général de l’Institut Pasteur, Paris Introduction |
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| Serge EHOLIE Université Félix Houphouet-Boigny, Abidjan Role of Mark Wainberg in promoting access to treatment in limited resource settings |
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| Françoise BRUN-VEZINET Université Paris 7 Denis Diderot, Hôpital Bichat Mark Weinberg’s achievements in the virology field |
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| Marc DIXNEUF Directeur Général de l’association AIDES, Paris Role of Mark Wainberg in promoting access to prevention |
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| Daniel Aaron DONAHUE Unité Virus et Immunité, Institut Pasteur, Paris Remembering Mark Wainberg as a mentor |
| Meeting number | 92 |
| Date | 18/04/2017 at 4 PM |
| Topic | Residual risk of HIV sexual transmission |
| Organizers | Jade Ghosn (Université Paris Descartes, EA 7327, Laboratoire de Virologie, Faculté de Médecine site Necker, Paris) |
| Speakers | Romulus BREBAN Unité d’Epidémiologie des Maladies Emergentes, Institut Pasteur, Paris Meta-analysis of the residual risk of sexual HIV transmission from efficiently treated persons |
| Jade GHOSN Université Paris Descartes, EA 7327, Laboratoire de Virologie, Faculté de Médecine site Necker, Paris Presence of HIV RNA in the seminal fluid of efficiently treated men |
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| Nathalie DEJUCQ Université de Rennes, INSERM U1085 – IRSET, Rennes Origin of HIV RNA in sperm and role of infected sperm cells |
| Meeting number | 91 |
| Date | 10/03/2017 at 12 AM |
| Topic | GRS International Seminar Series: Virology |
| Organizer | Nicoletta Casartelli (IP) |
| Speaker | Leo JAMES MRC, Cambridge, UK Dynamic pores in HIV capsid import nucleotides for DNA synthesis |
| Meeting number | 90 |
| Date | 25/01/2017 at 12 AM |
| Topic | GRS International Seminar Series: Virology |
| Organizer | Asier Saez-Cirion (IP) and ANRS AC32 |
| Speaker | Aftab ANSARI Emory University, Atlanta, USA A non-human primate model that serves to identify an alternative to a lifetime of ART |
GRS Meetings 2016
| Meeting number | 89 |
| Date | 15/12/2016 at 4 PM |
| Topic | HIV neutralizing antibodies |
| Organizers | Hugo Mouquet (IP) |
| Speakers | Mireia PELEGRIN Institut de Génétique Moléculaire de Montpellier Vaccinal effect of antiviral monoclonal antibodies: converting immunotherapies from passive to active |
| Pascal POIGNARD Institut de Biologie Structurale, Université de Grenoble Analyzing HIV broadly neutralizing antibody lineages to inform vaccine design |
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| Mélanie Bouvin-Pley Université de Tours Population-level evolution of the envelope glycoprotein of HIV-1 under the selective pressure of Nabs |
| Meeting number | 88 |
| Date | 10/05/2016 at 4 PM |
| Topic | TRIM / SUMO / Interferon in antiviral responses |
| Organizers | Lisa Chakrabarti (IP) |
| Speakers | Jack-Christophe COSSEC Organisation Nucléaire et Oncogénèse, Institut Pasteur, Paris Chromatin functions of SUMO in innate immunity |
| Nathalie ARHEL INSERM U941, Hôpital St Louis, Paris TRIM5alpha regulation by SUMOylation and nuclear sequestration ensures efficient innate sensing in dendritic cells |
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| Sébastien NISOLE INSERM UMR S1124, Centre Universitaire des Sainst-Pères, Paris PML/TRIM19-dependent inhibition of retroviral reverse-transcription by Daxx |
| Meeting number | 87 |
| Date | 20/04/2016 at 4 PM |
| Topic | GRS International Seminar Series: Virology |
| Organizer | Marc Lavigne (IP) and Pascale Lesage (St Louis Hospital, Inserm) |
| Speaker | Henry LEVIN Section of Transposable Elements, NICHD, NIH, Bethesda, USA Integration site selection: how transposable elements in S. Pombe and HIV-1 in human cells identify their targets |
| Meeting number | 86 |
| Date | 18/03/2016 at 2 PM |
| Topic | GRS International Seminar Series: Virology |
| Organizer | Nicoletta Casartelli (IP) |
| Speaker | Massimo PIZZATO Centre for Integrative Biology, University of Trento, Italy SERINC, an ancient defense against retroviruses |
| Meeting number | 85 |
| Date | 12/01/2016 at 4 PM |
| Topic | CD4+ T cells and HIV tissue reservoirs |
| Organizers | Lisa Chakrabarti (IP) |
| Speakers | Christine BOURGEOIS Inserm UMR 1184 / Centre IMVA, le Kremlin-Bicêtre CD4+ T cells in adipose tissue represent a neglected HIV/SIV reservoir |
| Pierre DELOBEL Inserm UMR 1043 / CHU Toulouse Chemotaxis of CD4+ T lymphocytes and immune reconstitution of the intestinal mucosa under ART |
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| Nabila SEDDIKI Vaccine Research Institute, Créteil Resident and circulating memory CD4+ T cells lacking SAMHD1 are highly sensitive to HIV-1 infection |
GRS Meetings 2015
| Meeting number | 84 |
| Date | 28/10/2015 at 12 AM |
| Topic | GRS International Seminar Series: Vaccinology |
| Organizer | Lisa Chakrabarti (IP) |
| Speaker | Zhiwei CHEN AIDS Institute, University of Hong Kong, HK PD-1-based vaccines for AIDS and cancer immunotherapy |
| Meeting number | 83 |
| Date | 28/04/2015 at 4 PM |
| Topic | Interactions of HIV-1 with the nuclear pore and chromatin factors |
| Organizers | Francesca di Nunzio (IP) et Nicoletta Casartelli (IP) |
| Speakers | Leo JAMES Medical Research Council, Cambridge, UK HIV-1 capsid recruits host cofactors to mediate nuclear import |
| Francesca DI NUNZIO Unité de Virologie Moléculaire et Vaccinologie, Institut Pasteur, Paris Chromatin organization at the nuclear pore favours HIV-1 replication |
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| Fulvio MAVILIO Genethon, Evry, France Lentiviral gene transfer vectors and the human genome |
| Meeting number | 82 |
| Date | 08/04/2015 at 4 PM |
| Topic | HIV primary infection |
| Organizers | Asier Saez-Cirion (IP) and the Concerted Action AC32 of ANRS |
| Speakers | Laurence MEYER Inserm U1018-CESP, Le Kremlin-Bicêtre The experience of the ANRS CO6 PRIMO cohort |
| Jintanat ANANWORANICH U.S. Military HIV Research Program, Walter Reed Army Institute of Research,Bethesda, USA Treatment of acute HIV infection: A critical step to HIV remission |
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| Laurence WEISS Hôpital Européen Georges Pompidou et IP, Paris Regulatory and effector CD4 responses during primary HIV infection |
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| John FRATER University of Oxford, UK Biomarkers to predict viral rebound after treatment interruption – fact or fantasy? |
GRS meetings have been held since 2002. The list of previous meetings can be obtained by contacting the GRS organizing committee at: grs@pasteur.fr
Useful links
UNAIDS : Program of the United Nations on HIV/AIDS.
SIDACTION : French association providing hep to HIV infected persons, and promoting HIV/AIDS prevention and research.
ANRS : French National Agency for the fight of HIV/AIDS and viral hepatitis B and C.
Medscape HIV/AIDS : Informations on HIV/AIDS for health professionals, summaries of AIDS conferences.
AMEDEO HIV infection : Bibliographic information service on HIV/AIDS.
HIV sequence database : Repertory of HIV nucleotide sequences and epitopes.
CROI 2019 presentations : listen to webcasts and podcasts of presentations made at the CROI conference (Conference on Retroviruses and Opportunistic Infections) which was held in Seattle in March 2019.
R4P 2018 presentations : listen to webcasts of presentations made at the “HIV Research for Prevention” conference which was held in Madrid in October 2018.
Contact us
For more information on the GRS meetings, or to suggest topics for future meetings, contact us at:
grs@pasteur.fr
Last updated March 11, 2020, by Lisa Chakrabarti.
