Stroma, inflammation et réparation tissulaire

The survival of organisms requires the ability to repair tissues upon injury, as well as, after birth, to fight foreign invaders that may have contaminated the wound. This last function is mediated by a […]

The intestine contains abundant and heterogeneous populations of stromal cells. Using several genetic approaches as well as intestinal organoid models, we are investigating the role of the stromal microenvironment in intestinal homeostasis and repair,  […]

Tumor progression, invasion and ultimately metastasis result from interactions between cancer cells and their supporting stromal microenvironment. The tumor stromal microenvironment share many similarities with fibrotic stroma and comprises extracellular matrix components, as well […]

In the human colon, mucus protects the underlying epithelium from pathogens. During infection, pathogens and resident microbiota compete for nutritional metabolites and therefore changes may alter the equilibrium in the colon ecosystem contributing to […]

The malignant transformation of cells translates into a major worldwide health, social and economic burden. Efforts to define the etiology of cancer, along with the development of new therapeutic approaches to treat them, would […]