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Call Emulate 2020 – Mucibiome – Impact of the colon mucus layer colonized by microbiota on the colonic epithelium mechanics under strech and on the pathogenesis of Entamoeba histolytica
In the human colon, mucus protects the underlying epithelium from pathogens. During infection, pathogens and resident microbiota compete for nutritional metabolites and therefore changes may alter the equilibrium in the colon ecosystem contributing to […]
Oncobiomics – THE (heterogenity tumor ecosystem)
The Oncobiomics project is conducted in the HTE (heterogenity tumor ecosystem) national program launched by the cancer nation institute (Inca) in the third national cancer plan 2014-2019. It’s a consortium project involving 8 teams […]
Impact of gut mechanical forces and 3D architecture on the intestine homeostasis during pathogen interaction and in cancer disease
The intestine, and in particular the colon, comprising a mucus blanket, an epithelial monolayer and the lamina propria rich in immune cells, is constantly subjected to shear stress (flow) and peristaltic motion (stretching), both […]
The stromal microenvironment in intestinal homeostasis / immunity
The intestine contains abundant and heterogeneous populations of stromal cells. Using several genetic approaches as well as intestinal organoid models, we are investigating the role of the stromal microenvironment in intestinal homeostasis and repair, […]
2022PDGFRα-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms., Cell Stem Cell 2022 May; 29(5): 856-868.e5.
2021A virus-derived microRNA targets immune response genes during SARS-CoV-2 infection, EMBO Reports (2021)e54341.
2021A virus-derived microRNA targets immune response genes during SARS-CoV-2 infection., EMBO Rep 2021 Dec; (): e54341.
2020Fermentation Products of Commensal Bacteria Alter Enterocyte Lipid Metabolism, Cell Host Microbe 2020 March 11;27:1-18.
2020Innate immune receptor NOD2 mediates LGR5 intestinal stem cell protection against ROS cytotoxicity via mitophagy stimulation, Proc. Natl. Acad. Sci. U.S.A. 2020 Jan;117(4):1994-2003.
2020Intracellular offspring released from SFB filaments are flagellated., Nat Microbiol 2020 01; 5(1): 34-39.
2019DNA Hypermethylation Downregulates Telomerase Reverse Transcriptase (TERT) during -Induced Chronic Inflammation, J Oncol 2019;2019:5415761.
2019Shigella-mediated oxygen depletion is essential for intestinal mucosa colonization., Nat Microbiol 2019 11; 4(11): 2001-2009.
2019Decrypting the communication between microbes and the intestinal mucosa-A brief review on Pathogénie Microbienne Moléculaire’s latest research, Cell. Microbiol. 2019 Nov;21(11):e13118.
2019Mapping of Shigella flexneri’s tissue distribution and type III secretion apparatus activity during infection of the large intestine of guinea pigs, Pathog Dis 2019 10;77(7).
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