Timeline
25 Aug 2018
patent
Glycoconjugates and their use as potential vaccines against infection by Shigella flexneri
Read more01 Nov 2016
publication
Heparan sulfate differentially controls CXCL12α- and CXCL12γ-mediated cell migration through differential presentation to their receptor CXCR4
Read more10 Oct 2016
publication
CD4-mimetic sulfopeptide conjugates display sub-nanomolar anti-HIV-1 activity and protect macaques against a SHIV162P3 vaginal challenge
Read more01 Aug 2014
publication
Well-defined biomimetic surfaces to characterize glycosaminoglycan-mediated interactions on the molecular, supramolecular and cellular levels
Read more28 Jun 2013
03 Oct 2012
publication
Homeostatic and tissue reparation defaults in mice carrying selective genetic invalidation of CXCL12/proteoglycan interactions
Read more04 Jun 2012
publication
CXCR3 antagonism of SDF-1(5-67) restores trabecular function and prevents retinal neurodegeneration in a rat model of ocular hypertension
Read more16 Mar 2012
publication
Design of a specific colonic mucus marker using a human commensal bacterium cell surface domain
Read more27 Jan 2012
publication
A synthetic heparan sulfate-mimetic peptide conjugated to a mini CD4 displays very high anti- HIV-1 activity independently of coreceptor usage
Read more23 Jul 2011
publication
Direct inhibition of NF-κB activation by peptide targeting the NOA ubiquitin binding domain of NEMO
Read more15 Apr 2011
publication
Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells
Read more01 Feb 2010
publication
Slightly modifying pseudoproline dipeptides incorporation strategy enables solid phase synthesis of a 54 AA fragment of caveolin-1 encompassing the intramembrane domain
Read more06 Sep 2009
publication
A synthetic CD4-heparan sulfate glycoconjugate inhibits CCR5 and CXCR4 HIV-1 attachment and entry
Read more28 Aug 2009
publication
Glycosaminoglycan mimetics inhibit SDF-1/CXCL12-mediated migration and invasion of human hepatoma cells
Read more17 Aug 2009
publication
Glycosaminoglycans and syndecan-4 are involved in SDF-1/CXCL12-mediated invasion of human epitheloid carcinoma HeLa cells
Read more20 Apr 2009
publication
CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling
Read more16 Sep 2008
publication
Sulfated oligosaccharides (heparin and fucoidan) binding and dimerization of stromal cell-derived factor-1 (SDF-1/CXCL 12) are coupled as evidenced by affinity CE-MS analysis
Read more02 Jul 2008
publication
The CXCL12gamma chemokine displays unprecedented structural and functional properties that make it a paradigm of chemoattractant proteins
Read more13 Jun 2008
24 Apr 2008
publication
CXCR4 dimerization and beta-arrestin-mediated signaling account for the enhanced chemotaxis to CXCL12 in WHIM syndrome
Read more19 Mar 2008
publication
Polypyrrole oligosaccharide array and surface plasmon resonance imaging for the measurement of glycosaminoglycan binding interactions
Read more01 Mar 2008
publication
Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling
Read more14 Nov 2007
publication
An ectromelia virus protein that interacts with chemokines through their glycosaminoglycan binding domain
Read more31 Oct 2007
publication
The novel CXCL12gamma isoform encodes an unstructured cationic domain which regulates bioactivity and interaction with both glycosaminoglycans and CXCR4
Read more01 Sep 2007
publication
Inhibition of NF-kappaB activation with designed ankyrin-repeat proteins targeting the ubiquitin-binding/oligomerization domain of NEMO
Read more15 Jul 2005
publication
Single-spanning membrane protein insertion in membrane mimetic systems: role and localization of aromatic residues
Read more10 Apr 2005
18 Feb 2005
publication
Synthesis of two linear PADRE conjugates bearing a deca- or pentadecasaccharide B epitope as potential synthetic vaccines against Shigella flexneri serotype 2a infection
Read more15 Dec 2004
publication
CXCR4-tropic HIV-1 envelope glycoprotein functions as a viral chemokine in unstimulated primary CD4+ T lymphocytes
Read more09 Nov 2004
publication
WHIM syndromes with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12
Read more20 Sep 2004
publication
Elastase release by transmigrating neutrophils deactivates endothelial-bound SDF-1alpha and attenuates subsequent T lymphocyte transendothelial migration
Read more02 Aug 2004
publication
Heparan sulfate/heparin oligosaccharides protect stromal cell-derived factor-1 (SDF-1)/CXCL12 against proteolysis induced by CD26/dipeptidyl peptidase IV
Read more26 Apr 2004
publication
Preparation of synthetic glycoconjugates as potential vaccines against Shigella flexneri serotype 2a disease
Read more01 Apr 2004
publication
Stromal cell-derived factor-1alpha promotes melanoma cell invasion across basement membranes involving stimulation of membrane-type 1 matrix metalloproteinase and Rho GTPase activities
Read more15 Mar 2003
publication
Role of the chemokine stromal cell-derived factor 1 in autoantibody production and nephritis in murine lupus
Read more22 Nov 2002
publication
Low levels of co-receptor CCR5 are sufficient to permit HIV envelope-mediated fusion with resting CD4 T cells
Read more19 Nov 2002
publication
Deciphering the role of individual acyl chains in the interaction network between phosphatidylserines and a single-spanning membrane protein
Read more01 Oct 2002
publication
Most of the structural elements of the globular domain of murine prion protein form fibrils with predominant beta-sheet structure
Read more26 Feb 2002
publication
Leukocyte elastase negatively regulates Stromal cell-derived factor-1 (SDF-1)/CXCR4 binding and functions by amino-terminal processing of SDF-1 and CXCR4
Read more15 Jan 2002
publication
Interleukin-10 modulates the sensitivity of peritoneal B lymphocytes to chemokines with opposite effects on stromal cell-derived factor-1 and B-lymphocyte chemoattractant
Read more21 Aug 2001
publication
Concerted influence of key amino acids on the lipid binding properties of a single-spanning membrane protein: NMR and mutational analysis
Read more14 May 2001
publication
Optimal inhibition of X4 HIV isolates by the CXC chemokine stromal cell-derived factor 1 alpha requires interaction with cell surface heparan sulfate proteoglycans
Read more01 Feb 2001
publication
Production of stromal cell-derived factor 1 by mesothelial cells and effects of this chemokine on peritoneal B lymphocytes
Read more21 Nov 2000
01 Nov 2000
publication
Mimicking a conformational B cell epitope of the heat shock protein PfHsp70-1 antigen of Plasmodium falciparum using a multiple antigenic peptide
Read more01 Sep 2000
21 Aug 2000
publication
Subsecond induction of alpha4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions
Read more01 Aug 2000
publication
Signal transduction by CXC chemokine receptor 4. Stromal cell-derived factor 1 stimulates prolonged protein kinase B and extracellular signal-regulated kinase 2 activation in T lymphocytes
Read more01 Jan 2000
publication
Differential signalling of the chemokine receptor CXCR4 by stromal cell-derived factor 1 and the HIV glycoprotein in rat neurons and astrocytes
Read more01 Dec 1999
publication
Multiple charged and aromatic residues in CCR5 amino-terminal domain are involved in high affinity binding of both chemokines and HIV-1 Env protein
Read more20 Aug 1999
publication
Stromal cell-derived factor-1alpha associates with heparan sulfates through the first beta-strand of the chemokine
Read more01 Jul 1998
publication
A conformational equilibrium in a protein fragment caused by two consecutive capping boxes: 1H-, 13C-NMR, and mutational analysis
Read more26 Jun 1998
publication
Exploring the folding pathways of annexin I, a multidomain protein. I. non-native structures stabilize the partially folded state of the isolated domain 2 of annexin I
Read more17 Apr 1998
01 Mar 1998
publication
Human immunodeficiency virus (HIV) envelope binds to CXCR4 independently of CD4, and binding can be enhanced by interaction with soluble CD4 or by HIV envelope deglycosylation
Read more01 Feb 1998
publication
Does a peptide bound to a monoclonal antibody always adopt a unique conformation?
Read more01 Jan 1998
publication
Spontaneous mutations in the env gene of the human immunodeficiency virus type 1 NDK isolate are associated with a CD4-independent entry phenotype
Read more26 Nov 1996
publication
NMR conformational study of the cytoplasmic domain of the canine Sec61 gamma protein from the protein translocation pore of the endoplasmic reticulum membrane
Read more13 Aug 1996
01 Jun 1996
publication
Identification of lysine residues required for signal-induced ubiquitination and degradation of I kappa B-alpha in vivo
Read more01 May 1996
publication
Permanent occupancy of the human immunodeficiency virus type 1 enhancer by NF-kappa B is needed for persistent viral replication in monocytes
Read more29 Mar 1996
publication
Role of IkappaBalpha ubiquitination in signal-induced activation of NFkappaB in vivo
Read more01 Oct 1995
publication
Chemical structure and translation inhibition studies of the antibiotic microcin C7
Read more01 Oct 1995
publication
Nonnative capping structure initiates helix folding in an annexin I fragment. A 1H NMR conformational study
Read more29 Apr 1995
publication
Nascent chains: folding and chaperone interaction during elongation on ribosomes
Read more01 Mar 1995
publication
Importance of residues 2-9 in the immunoreactivity, subunit interactions, and activity of the beta 2 subunit of Escherichia coli tryptophan synthase
Read more20 Jul 1993
publication
Proton NMR conformational study of an annexin I fragment: influence of a phospholipidic micellar environment
Read more01 Jul 1992
publication
Novel version of Multiple Antigenic Peptide allowing incorporation on a cysteine functionalized lysine tree
Read more10 Mar 1992
publication
Peptide secondary structure induced by a micellar phospholipidic interface: proton NMR conformational study of a lipopeptide
Read more01 Feb 1992
publication
1H-NMR conformational study of a synthetic peptide derived from the consensus sequence of annexins
Read more01 Nov 1991
publication
1H-NMR conformational analysis of a high-affinity antigenic 11-residue peptide from the tryptophan synthase beta 2 subunit
Read more01 Apr 1991
publication
Peptide/antibody recognition: synthetic peptides derived from the E. coli tryptophan synthase beta 2 subunit interact with high affinity with an anti-beta 2 monoclonal antibody
Read more01 Dec 1989
01 Oct 1989
publication
A new cell surface molecule closely related to mouse class I transplantation antigens
Read more01 May 1977