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© Valérie Choumet
Mosquitoes were orally infected with the chikungunya virus. Midguts were dissected at day 5 post-infection, fixed and permeabilised. Virus is shown in red (anti-E2 protein, cyanine 3), the actin network in green (phalloidin 548) and nuclei in blue (DAPI).
Publication : European journal of immunology

A new cell surface molecule closely related to mouse class I transplantation antigens

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in European journal of immunology - 01 Oct 1989

Cochet M, Casrouge A, Dumont AM, Transy C, Baleux F, Maloy WL, Coligan JE, Cazenave PA, Kourilsky P

Link to Pubmed [PMID] – 2583228

Eur. J. Immunol. 1989 Oct;19(10):1927-31

The “37” H-2 class I mouse gene, located in the Tla complex, is poorly polymorphic and is transcribed in a wide variety of cells and tissues. Using antisera directed against peptides deduced from the gene sequence, we demonstrate that the 37 gene encodes a 45.5-kDa cell surface glycoprotein. This protein, initially identified on the surface of mouse L cells transfected with an overexpressing 37 gene, is present on cells such as splenocytes of various mouse strains except those of A/J mice. Thus, mouse cells may express not only the major transplantation antigens encoded by the K and D region genes, but at least one additional poorly polymorphic class I molecule encoded by the 37 gene.

http://www.ncbi.nlm.nih.gov/pubmed/2583228