Timeline

Jean-Christophe Barale
Group Leader
18 Dec 2015
project

Background and Rationale

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16 Jul 2015
team

Biology of Malaria targets and Antimalarials

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11 May 2015
team

Trypanosomatids Infectious Processes

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11 May 2015
team

Structural Microbiology

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24 Oct 2014
publication

Computational design of protein-based inhibitors of Plasmodium vivax subtilisin-like 1 protease

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22 Oct 2014
publication

A small-molecule cell-based screen led to the identification of biphenylimidazoazines with highly potent and broad-spectrum anti-apicomplexan activity

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10 Sep 2014
publication

A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase

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21 Mar 2014
publication

Cytometric measurement of in vitro inhibition of Plasmodium falciparum field isolates by drugs: a new approach for re-invasion inhibition study

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27 Jan 2014
publication

Whole Pichia pastoris yeast expressing measles virus nucleoprotein as a production and delivery system to multimerize Plasmodium antigens

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18 Dec 2013
publication

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

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07 May 2013
publication

In Silico screening on the three-dimensional model of the Plasmodium vivax SUB1 protease leads to the validation of a novel anti-parasite compound

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01 Jan 2013
publication

Screening and evaluation of inhibitors of Plasmodium falciparum merozoite egress and invasion using cytometry

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03 Dec 2012
publication

Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western Cambodia

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25 Aug 2011
publication

FLP/FRT-mediated conditional mutagenesis in pre-erythrocytic stages of Plasmodium berghei

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27 Jul 2011
publication

Computational reverse-engineering of a spider-venom derived peptide active against Plasmodium falciparum SUB1

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01 Jan 2011
publication

On the Knorr synthesis of 6-bromo-4-methylquinolin-2(1H)-one

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18 Mar 2010
publication

Centromeric plasmids and artificial chromosomes: new kids on the Plasmodium transfection block

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06 Apr 2009
publication

Drug inhibition of HDAC3 and epigenetic control of differentiation in Apicomplexa parasites

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01 Oct 2005
publication

Trypanosoma cruzi proline racemases are involved in parasite differentiation and infectivity

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01 May 2005
publication

LANCL1, an erythrocyte protein recruited to the Maurer’s clefts during Plasmodium falciparum development

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04 Mar 2005
publication

CyProQuant-PCR: a real time RT-PCR technique for profiling human cytokines, based on external RNA standards, readily automatable for clinical use

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01 Jan 2004
publication

Gene targeting demonstrates that the Plasmodium berghei subtilisin PbSUB2 is essential for red cell invasion and reveals spontaneous genetic recombination events

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01 Oct 2002
publication

Three multigene families in Plasmodium parasites: facts and questions

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01 Nov 2000
publication

Pfsbp1, a Maurer’s cleft Plasmodium falciparum protein, is associated with the erythrocyte skeleton

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25 May 1999
publication

Plasmodium falciparum subtilisin-like protease 2, a merozoite candidate for the merozoite surface protein 1-42 maturase

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16 Feb 1999
publication

Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization

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24 Jul 1998
publication

The LIM homeobox protein mLIM3/Lhx3 induces expression of the prolactin gene by a Pit-1/GHF-1-independent pathway in corticotroph AtT20 cells

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01 Aug 1997
publication

Plasmodium falciparum AARP1, a giant protein containing repeated motifs rich in asparagine and aspartate residues, is associated with the infected erythrocyte membrane

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01 Aug 1997
publication

Plasmodium falciparum asparagine and aspartate rich protein 2 is an evolutionary conserved protein whose repeats identify a new family of parasite antigens

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01 Dec 1994
publication

The mouse homeoprotein mLIM-3 is expressed early in cells derived from the neuroepithelium and persists in adult pituitary

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01 Feb 1994
publication

Malaria parasites: enzymes involved in red blood cell invasion

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01 Jun 1993
publication

Isolation from a Plasmodium chabaudi chromosome 7 specific library of a novel gene encoding a protein with multiple GGMP repeats homologous to hsp70

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15 Oct 1992
publication

Plasmodium chabaudi p68 serine protease activity required for merozoite entry into mouse erythrocytes

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01 Oct 1992
publication

A Plasmodium falciparum gene coding for a 15-kilodalton antigen expressed in asexual stage parasites, gametocytes and gametes

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14 Nov 1991
publication

The C-terminal domain of RNA polymerase II of the malaria parasite Plasmodium berghei

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01 Oct 1991
publication

Malarial proteases: assignment of function to activity

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