Timeline

Cosmin Saveanu

Group Leader

01 Jan 2025

publication

Dynamic Evolution of Poly-A Tail Lengths Visualized by RNAse H Assay and Northern Blot Using Nonradioactive Probes in Yeast.

01 Jan 2025

publication

Minimal Perturbation Analysis of mRNA Degradation Rates with Tet-Off and RT-qPCR.

08 Nov 2024

course

Multiple roles of RNAs

09 Oct 2024

publication

Specific Requirement of the p84/p110γ Complex of PI3Kγ for Antibody-Activated, Inducible Cross-Presentation in Murine Type 2 DCs.

27 Sep 2024

publication

Structure of the Nmd4-Upf1 complex supports conservation of the nonsense-mediated mRNA decay pathway between yeast and humans.

25 Sep 2024

publication

RNA degradation triggered by decapping is largely independent of initial deadenylation.

16 Jan 2023

publication

Deadenylation rate is not a major determinant of RNA degradation in yeast

21 Nov 2022

news

“RNA modifications and epitranscriptomics” – November 14th, 2023

28 Sep 2022

event

Symposium: RNA modifications and epitranscriptomics

10 Mar 2022

publication

Unusual SMG suspects recruit degradation enzymes in nonsense-mediated mRNA decay.

03 Feb 2022

course

Multiple roles of RNAs

01 Jan 2022

publication

Composition and Dynamics of Protein Complexes Measured by Quantitative Mass Spectrometry of Affinity-Purified Samples.

22 Oct 2021

news

Back on: Science Outreach during the Departmental retreat in Pornichet 2021

24 Sep 2021

news

Highlighted Publication : “Investigation of RNA metabolism through large-scale genetic interaction profiling in yeast”, Decourty, L et al., NAR, 2021 Sep 7;49(15) – Genetics of Macromolecular Interactions team

07 Sep 2021

publication

Investigation of RNA metabolism through large-scale genetic interaction profiling in yeast.

25 Mar 2021

publication

The box C/D snoRNP assembly factor Bcd1 interacts with the histone chaperone Rtt106 and controls its transcription dependent activity.

18 Mar 2021

publication

Ethylzingerone, a Novel Compound with Antifungal Activity.

05 Oct 2020

publication

Investigation of RNA metabolism through large-scale genetic interaction profiling in yeast

01 May 2019

publication

The puzzling construction of the conidial outer layer of Aspergillus fumigatus.

01 Oct 2018

publication

Nonsense-mediated mRNA decay involves two distinct Upf1-bound complexes

14 Sep 2018

publication

UPF1-like helicase grip on nucleic acids dictates processivity

21 Jul 2017

publication

MybA, a transcription factor involved in conidiation and conidial viability of the human pathogen Aspergillus fumigatus

17 Mar 2017

publication

Exposure to selenomethionine causes selenocysteine misincorporation and protein aggregation in Saccharomyces cerevisiae

05 Dec 2016

publication

Actin activates Pseudomonas aeruginosa ExoY nucleotidyl cyclase toxin and ExoY-like effector domains from MARTX toxins

27 Apr 2016

publication

How cells kill a “killer” messenger

01 Jan 2016

publication

Identification of Links Between Cellular Pathways by Genetic Interaction Mapping (GIM) (book chapter)

18 Sep 2015

project

A personal database system for large scale quantitative results exploration (Cassandre, PTR 463)

20 Jul 2015

publication

Brr2p carboxy-terminal Sec63 domain modulates Prp16 splicing RNA helicase

16 Jul 2015

team

Group: Translation dependent mRNA degradation

16 Jul 2015

team

RNA Biology of Fungal Pathogens

09 Jun 2015

project

Non-sense mediated mRNA decay mechanisms

23 Apr 2015

publication

Quality control of transcription start site selection by nonsense-mediated-mRNA decay

09 Feb 2015

project

Genome-wide genetic screens by GIM (Genetic Interactions Mapping)

06 Jun 2014

publication

mRNA Degradation and Decay (book chapter)

24 Feb 2014

publication

Self-assembly of the general membrane-remodeling protein PVAP into sevenfold virus-associated pyramids

13 Feb 2014

publication

Long open reading frame transcripts escape nonsense-mediated mRNA decay in yeast

13 Aug 2013

publication

Yeast ribosomal protein L7 and its homologue Rlp7 are simultaneously present at distinct sites on pre-60S ribosomal particles

11 Mar 2013

publication

Cdc48-associated complex bound to 60S particles is required for the clearance of aberrant translation products

01 Feb 2013

publication

Synergy of the antibiotic colistin with echinocandin antifungals in Candida species

07 May 2012

publication

Sodium selenide toxicity is mediated by O2-dependent DNA breaks

01 Apr 2011

publication

Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs

26 Mar 2010

publication

Ecm1 is a new pre-ribosomal factor involved in pre-60S particle export

25 Jul 2008

publication

60S ribosomal subunit assembly dynamics defined by semi-quantitative mass spectrometry of purified complexes

30 Jun 2008

publication

A yeast exosome cofactor, Mpp6, functions in RNA surveillance and in the degradation of noncoding RNA transcripts

11 Apr 2008

publication

Linking functionally related genes by sensitive and quantitative characterization of genetic interaction profiles

23 Jul 2007

publication

Cytoplasmic recycling of 60S preribosomal factors depends on the AAA protein Drg1

16 Feb 2007

publication

The p21-activated protein kinase inhibitor Skb15 and its budding yeast homologue are 60S ribosome assembly factors

21 Jul 2006

publication

Nsa2 is an unstable, conserved factor required for the maturation of 27 SB pre-rRNAs

01 May 2006

publication

A functional network involved in the recycling of nucleocytoplasmic pre-60S factors

01 Jun 2005

publication

RNA degradation by the exosome is promoted by a nuclear polyadenylation complex

01 Jun 2005

publication

Cryptic pol II transcripts are degraded by a nuclear quality control pathway involving a new poly(A) polymerase

27 Jan 2005

publication

Staphylococcus aureus RNAIII and the endoribonuclease III coordinately regulate spa gene expression

01 Jul 2004

publication

Targeted mRNA degradation by deadenylation-independent decapping

27 May 2004

publication

The ribosomal protein Rps15p is required for nuclear exit of the 40S subunit precursors in yeast

14 Aug 2003

publication

Ribosome assembly in eukaryotes

01 Jul 2003

publication

Sequential protein association with nascent 60S ribosomal particles

01 Nov 2002

publication

Structural and nucleotide-binding properties of YajQ and YnaF, two Escherichia coli proteins of unknown function

01 Mar 2002

publication

Spc24 interacts with Mps2 and is required for chromosome segregation, but is not implicated in spindle pole body duplication

15 Nov 2001

publication

Nog2p, a putative GTPase associated with pre-60S subunits and required for late 60S maturation steps

14 Feb 2001

publication

Identification of 12 new yeast mitochondrial ribosomal proteins including 6 that have no prokaryotic homologues

01 Feb 2000

publication

A little guide for advanced search:

Dynamic Evolution of Poly-A Tail Lengths Visualized by RNAse H Assay and Northern Blot Using Nonradioactive Probes in Yeast.

Minimal Perturbation Analysis of mRNA Degradation Rates with Tet-Off and RT-qPCR.

Multiple roles of RNAs

Specific Requirement of the p84/p110γ Complex of PI3Kγ for Antibody-Activated, Inducible Cross-Presentation in Murine Type 2 DCs.

Structure of the Nmd4-Upf1 complex supports conservation of the nonsense-mediated mRNA decay pathway between yeast and humans.

RNA degradation triggered by decapping is largely independent of initial deadenylation.

Deadenylation rate is not a major determinant of RNA degradation in yeast

“RNA modifications and epitranscriptomics” – November 14th, 2023

Symposium: RNA modifications and epitranscriptomics

Unusual SMG suspects recruit degradation enzymes in nonsense-mediated mRNA decay.

Multiple roles of RNAs

Composition and Dynamics of Protein Complexes Measured by Quantitative Mass Spectrometry of Affinity-Purified Samples.

Back on: Science Outreach during the Departmental retreat in Pornichet 2021

Highlighted Publication : “Investigation of RNA metabolism through large-scale genetic interaction profiling in yeast”, Decourty, L et al., NAR, 2021 Sep 7;49(15) – Genetics of Macromolecular Interactions team

Investigation of RNA metabolism through large-scale genetic interaction profiling in yeast.

The box C/D snoRNP assembly factor Bcd1 interacts with the histone chaperone Rtt106 and controls its transcription dependent activity.

Ethylzingerone, a Novel Compound with Antifungal Activity.

Investigation of RNA metabolism through large-scale genetic interaction profiling in yeast

The puzzling construction of the conidial outer layer of Aspergillus fumigatus.

Nonsense-mediated mRNA decay involves two distinct Upf1-bound complexes

UPF1-like helicase grip on nucleic acids dictates processivity

MybA, a transcription factor involved in conidiation and conidial viability of the human pathogen Aspergillus fumigatus

Exposure to selenomethionine causes selenocysteine misincorporation and protein aggregation in Saccharomyces cerevisiae

Actin activates Pseudomonas aeruginosa ExoY nucleotidyl cyclase toxin and ExoY-like effector domains from MARTX toxins

How cells kill a “killer” messenger

Identification of Links Between Cellular Pathways by Genetic Interaction Mapping (GIM) (book chapter)

A personal database system for large scale quantitative results exploration (Cassandre, PTR 463)

Brr2p carboxy-terminal Sec63 domain modulates Prp16 splicing RNA helicase

Group: Translation dependent mRNA degradation

RNA Biology of Fungal Pathogens

Non-sense mediated mRNA decay mechanisms

Quality control of transcription start site selection by nonsense-mediated-mRNA decay

Genome-wide genetic screens by GIM (Genetic Interactions Mapping)

mRNA Degradation and Decay (book chapter)

Self-assembly of the general membrane-remodeling protein PVAP into sevenfold virus-associated pyramids

Long open reading frame transcripts escape nonsense-mediated mRNA decay in yeast

Yeast ribosomal protein L7 and its homologue Rlp7 are simultaneously present at distinct sites on pre-60S ribosomal particles

Cdc48-associated complex bound to 60S particles is required for the clearance of aberrant translation products

Synergy of the antibiotic colistin with echinocandin antifungals in Candida species

Sodium selenide toxicity is mediated by O2-dependent DNA breaks

Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs

Ecm1 is a new pre-ribosomal factor involved in pre-60S particle export

60S ribosomal subunit assembly dynamics defined by semi-quantitative mass spectrometry of purified complexes

A yeast exosome cofactor, Mpp6, functions in RNA surveillance and in the degradation of noncoding RNA transcripts

Linking functionally related genes by sensitive and quantitative characterization of genetic interaction profiles

Cytoplasmic recycling of 60S preribosomal factors depends on the AAA protein Drg1

The p21-activated protein kinase inhibitor Skb15 and its budding yeast homologue are 60S ribosome assembly factors

Nsa2 is an unstable, conserved factor required for the maturation of 27 SB pre-rRNAs

A functional network involved in the recycling of nucleocytoplasmic pre-60S factors

RNA degradation by the exosome is promoted by a nuclear polyadenylation complex

Cryptic pol II transcripts are degraded by a nuclear quality control pathway involving a new poly(A) polymerase

Staphylococcus aureus RNAIII and the endoribonuclease III coordinately regulate spa gene expression

Targeted mRNA degradation by deadenylation-independent decapping

The ribosomal protein Rps15p is required for nuclear exit of the 40S subunit precursors in yeast

Ribosome assembly in eukaryotes

Sequential protein association with nascent 60S ribosomal particles

Structural and nucleotide-binding properties of YajQ and YnaF, two Escherichia coli proteins of unknown function

Spc24 interacts with Mps2 and is required for chromosome segregation, but is not implicated in spindle pole body duplication

Nog2p, a putative GTPase associated with pre-60S subunits and required for late 60S maturation steps

Identification of 12 new yeast mitochondrial ribosomal proteins including 6 that have no prokaryotic homologues

Genetic and biochemical characterization of Salmonella enterica serovar typhi deoxyribokinase