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© Research
Publication : BioEssays

Unusual SMG suspects recruit degradation enzymes in nonsense-mediated mRNA decay.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in BioEssays - 10 Mar 2022

Gilbert A, Saveanu C.

Link to Pubmed [PMID] – 35266563

Link to DOI – 10.1002/bies.202100296

Link to HAL - Pasteur – https://hal-pasteur.archives-ouvertes.fr/pasteur-03606359

Bioessays 2022 Mar; (): e2100296

Degradation of eukaryotic RNAs that contain premature termination codons (PTC) during nonsense-mediated mRNA decay (NMD) is initiated by RNA decapping or endonucleolytic cleavage driven by conserved factors. Models for NMD mechanisms, including recognition of PTCs or the timing and role of protein phosphorylation for RNA degradation are challenged by new results. For example, the depletion of the SMG5/7 heterodimer, thought to activate RNA degradation by decapping, leads to a phenotype showing a defect of endonucleolytic activity of NMD complexes. This phenotype is not correlated to a decreased binding of the endonuclease SMG6 with the core NMD factor UPF1, suggesting that it is the result of an imbalance between active (e.g., in polysomes) and inactive (e.g., in RNA-protein condensates) states of NMD complexes. Such imbalance between multiple complexes is not restricted to NMD and should be taken into account when establishing causal links between gene function perturbation and observed phenotypes.

https://pubmed.ncbi.nlm.nih.gov/35266563