Timeline

Timothy Wai

Head of Structure

11 Apr 2025

event

BCI & BSC joint Seminar – “Conformational flexibility and molecular plasticity in herpesvirus entry and egress”

01 Oct 2024

publication

Is mitochondrial morphology important for cellular physiology?

11 Jun 2024

publication

Dynamic label-free analysis of SARS-CoV-2 infection reveals virus-induced subcellular remodeling.

20 Dec 2023

news

New publication – Mtfp1 ablation enhances mitochondrial respiration and protects against hepatic steatosis

20 Dec 2023

publication

Mtfp1 ablation enhances mitochondrial respiration and protects against hepatic steatosis.

10 Oct 2023

project

MitoDeath: Dissecting the molecular mechanisms responsible for a mitochondrial defect leading to motor neuron death (FRM)

10 Oct 2023

project

IMHOTEP: Role of hepatocyte mitochondrial dysfunction in the occurrence and progression of NAFLD (ANR)

10 Oct 2023

project

MitoCure: Mitochondrial Disease Platform-Institut Pasteur (ArgoBIO et Institut Pasteur)

01 Mar 2023

publication

MPC2 variants disrupt mitochondrial pyruvate metabolism and cause an early-onset mitochondriopathy.

20 Feb 2023

event

BCI seminar – “The roles of lipids in cell biology”

01 Feb 2023

event

BCI seminar – “Collective effects in epithelial cell elimination”

01 Feb 2023

event

BCI Seminar – “Deciphering the spatiotemporal and mechanical regulation of integrin and actin regulators at the nanoscale”

03 Jan 2023

news

New publication – Mitochondrial Fission Process 1 controls inner membrane integrity and protects against heart failure

01 Jan 2023

publication

Mitochondrial dynamics and metabolic regulation control T cell fate in the thymus.

04 Nov 2022

publication

Mitochondrial Fission Process 1 controls inner membrane integrity and protects against heart failure.

21 Oct 2022

publication

CHCHD10 and SLP2 control the stability of the PHB complex: a key factor for motor neuron viability.

09 May 2022

event

Combination of spectroscopy with microscopy enables new dimensions in quantitative biology – Leonel Malacrida, IP Montevideo

06 Apr 2022

event

Microbes and Mitochondria – An international symposium in honor of Fabrizia Stavru

09 Nov 2021

publication

Mitochondrial respiration restricts Listeria monocytogenes infection by slowing down host cell receptor recycling.

18 Oct 2021

publication

Mitochondrial dysfunction caused by novel ATAD3A mutations.

04 Oct 2021

publication

Enhanced cGAS-STING-dependent interferon signaling associated with mutations in ATAD3A.

07 Jun 2021

publication

High-throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts.

27 May 2021

news

Mitochondrial diseases: a new screening leads to insight on the effect of various genes on DOA

01 May 2021

publication

Distinct fission signatures predict mitochondrial degradation or biogenesis.

05 Apr 2021

publication

Quality control of the mitochondrion.

01 Jan 2021

publication

Mitochondrial Nucleic Acid as a Driver of Pathogenic Type I Interferon Induction in Mendelian Disease.

26 Aug 2019

event

BCI Seminar – “Cytoskeletal cross-talk with integrin adhesion complexes in cell morphogenesis”

01 Jan 2019

publication

Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy.

03 Jun 2018

project

Fat4Heart ERA-CVD 2016

01 Jun 2018

team

Mitochondrial Biology

01 Aug 2017

publication

Lung ultrasound as a translational approach for non-invasive assessment of heart failure with reduced or preserved ejection fraction in mice

13 Oct 2016

publication

The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L

06 Aug 2016

publication

Homozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial network fragmentation

02 Jan 2016

publication

Mitochondrial Dynamics and Metabolic Regulation

04 Dec 2015

publication

Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice

06 Aug 2015

publication

SLIRP Regulates the Rate of Mitochondrial Protein Synthesis and Protects LRPPRC from Degradation

16 Mar 2015

publication

Stomatin-like protein 2 is required for in vivo mitochondrial respiratory chain supercomplex formation and optimal cell function

12 Feb 2015

publication

The Mitochondrial Metallochaperone SCO1 Is Required to Sustain Expression of the High-Affinity Copper Transporter CTR1 and Preserve Copper Homeostasis

10 Mar 2014

publication

The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission

06 Aug 2013

publication

TRIAP1/PRELI complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid

07 Oct 2012

publication

Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission

14 Oct 2010

publication

Gimap3 regulates tissue-specific mitochondrial DNA segregation

03 Mar 2010

publication

LRPPRC and SLIRP interact in a ribonucleoprotein complex that regulates posttranscriptional gene expression in mitochondria

03 Feb 2010

publication

The role of mitochondrial DNA copy number in mammalian fertility

01 Dec 2008

publication

The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes

15 Feb 2008

publication

Medicine. Sidestepping mutational meltdown

01 Jan 2007

publication

Mitochondrial DNA and the mammalian oocyte

09 Jun 2006

publication

A hemizygous SCO2 mutation in an early onset rapidly progressive, fatal cardiomyopathy

01 Dec 2004

publication

Mutations in the MMAA gene in patients with the cblA disorder of vitamin B12 metabolism

15 Dec 2002

publication

A little guide for advanced search:

BCI & BSC joint Seminar – “Conformational flexibility and molecular plasticity in herpesvirus entry and egress”

Is mitochondrial morphology important for cellular physiology?

Dynamic label-free analysis of SARS-CoV-2 infection reveals virus-induced subcellular remodeling.

New publication – Mtfp1 ablation enhances mitochondrial respiration and protects against hepatic steatosis

Mtfp1 ablation enhances mitochondrial respiration and protects against hepatic steatosis.

MitoDeath: Dissecting the molecular mechanisms responsible for a mitochondrial defect leading to motor neuron death (FRM)

IMHOTEP: Role of hepatocyte mitochondrial dysfunction in the occurrence and progression of NAFLD (ANR)

MitoCure: Mitochondrial Disease Platform-Institut Pasteur (ArgoBIO et Institut Pasteur)

MPC2 variants disrupt mitochondrial pyruvate metabolism and cause an early-onset mitochondriopathy.

BCI seminar – “The roles of lipids in cell biology”

BCI seminar – “Collective effects in epithelial cell elimination”

BCI Seminar – “Deciphering the spatiotemporal and mechanical regulation of integrin and actin regulators at the nanoscale”

New publication – Mitochondrial Fission Process 1 controls inner membrane integrity and protects against heart failure

Mitochondrial dynamics and metabolic regulation control T cell fate in the thymus.

Mitochondrial Fission Process 1 controls inner membrane integrity and protects against heart failure.

CHCHD10 and SLP2 control the stability of the PHB complex: a key factor for motor neuron viability.

Combination of spectroscopy with microscopy enables new dimensions in quantitative biology – Leonel Malacrida, IP Montevideo

Microbes and Mitochondria – An international symposium in honor of Fabrizia Stavru

Mitochondrial respiration restricts Listeria monocytogenes infection by slowing down host cell receptor recycling.

Mitochondrial dysfunction caused by novel ATAD3A mutations.

Enhanced cGAS-STING-dependent interferon signaling associated with mutations in ATAD3A.

High-throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts.

Mitochondrial diseases: a new screening leads to insight on the effect of various genes on DOA

Distinct fission signatures predict mitochondrial degradation or biogenesis.

Quality control of the mitochondrion.

Mitochondrial Nucleic Acid as a Driver of Pathogenic Type I Interferon Induction in Mendelian Disease.

BCI Seminar – “Cytoskeletal cross-talk with integrin adhesion complexes in cell morphogenesis”

Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy.

Fat4Heart ERA-CVD 2016

Mitochondrial Biology

Lung ultrasound as a translational approach for non-invasive assessment of heart failure with reduced or preserved ejection fraction in mice

The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L

Homozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial network fragmentation

Mitochondrial Dynamics and Metabolic Regulation

Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice

SLIRP Regulates the Rate of Mitochondrial Protein Synthesis and Protects LRPPRC from Degradation

Stomatin-like protein 2 is required for in vivo mitochondrial respiratory chain supercomplex formation and optimal cell function

The Mitochondrial Metallochaperone SCO1 Is Required to Sustain Expression of the High-Affinity Copper Transporter CTR1 and Preserve Copper Homeostasis

The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission

TRIAP1/PRELI complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid

Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission

Gimap3 regulates tissue-specific mitochondrial DNA segregation

LRPPRC and SLIRP interact in a ribonucleoprotein complex that regulates posttranscriptional gene expression in mitochondria

The role of mitochondrial DNA copy number in mammalian fertility

The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes

Medicine. Sidestepping mutational meltdown

Mitochondrial DNA and the mammalian oocyte

A hemizygous SCO2 mutation in an early onset rapidly progressive, fatal cardiomyopathy

Mutations in the MMAA gene in patients with the cblA disorder of vitamin B12 metabolism

Identification of the gene responsible for the cblB complementation group of vitamin B12-dependent methylmalonic aciduria