Timeline

Bertrand Raynal

Research Engineer

13 Mar 2024

publication

Prodomain-driven enzyme dimerization: a pH-dependent autoinhibition mechanism that controls Plasmodium Sub1 activity before merozoite egress.

06 Dec 2023

publication

Acetylation regulates the oligomerization state and activity of RNase J, the Helicobacter pylori major ribonuclease.

01 Aug 2023

publication

Raynals, an online tool for the analysis of dynamic

20 Jun 2023

publication

Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMPDHs.

27 Apr 2023

project

DNA-binding mechanism and evolution of replication protein A

22 Apr 2023

publication

DNA-binding mechanism and evolution of replication protein A.

11 Jan 2023

publication

The c-di-AMP-binding protein CbpB modulates the level of ppGpp alarmone in Streptococcus agalactiae.

01 Jan 2023

publication

Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity.

24 May 2022

publication

Dengue virus NS1 protein conveys pro-inflammatory signals by docking onto high-density lipoproteins.

01 Jan 2022

publication

Deciphering the Molecular Interaction Between the Adhesion G Protein-Coupled Receptor ADGRV1 and its PDZ-Containing Regulator PDZD7.

30 Nov 2021

publication

Actinobacteria challenge the paradigm: A unique protein architecture for a well-known, central metabolic complex.

21 Jul 2021

publication

SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction.

14 May 2021

publication

Quality control of protein reagents for the improvement of research data reproducibility.

01 May 2021

publication

A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells.

01 May 2021

publication

Quality control of purified proteins to improve data quality and reproducibility: results from a large-scale survey.

24 Apr 2021

publication

RNase R is associated in a functional complex with the RhpA DEAD-box RNA helicase in Helicobacter pylori.

01 Jan 2021

publication

PDZ Sample Quality Assessment by Biochemical and Biophysical Characterizations.

06 Nov 2020

publication

Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners.

15 May 2019

publication

Structural and functional characterization of the PDZ domain of the human phosphatase PTPN3 and its interaction with the human papillomavirus E6 oncoprotein.

07 May 2019

publication

Structural insights into the functional versatility of an FHA domain protein in mycobacterial signaling.

01 May 2019

publication

Regulation of measles virus gene expression by P protein coiled-coil properties.

07 Feb 2019

publication

Overall Structures of Mycobacterium tuberculosis DNA Gyrase Reveal the Role of a Corynebacteriales GyrB-Specific Insert in ATPase Activity

09 Jan 2019

publication

Biochemical characterization of the respiratory syncytial virus N0-P complex in solution

09 Jan 2019

publication

Biochemical characterization of the respiratory syncytial virus N-P complex in solution

11 Sep 2018

publication

Characterization of neutralizing antibodies reacting with the 213-224 amino-acid segment of human galectin-9

15 Jan 2018

publication

The stress sigma factor of RNA polymerase RpoS/σ is a solvent-exposed open molecule in solution

12 Jan 2018

publication

Calcium-dependent disorder-to-order transitions are central to the secretion and folding of the CyaA toxin of Bordetella pertussis, the causative agent of whooping cough.

28 Sep 2017

publication

Structural Characterization of Whirlin Reveals an Unexpected and Dynamic Supramodule Conformation of Its PDZ Tandem

01 Aug 2017

publication

Conformational switch of harmonin, a submembrane scaffold protein of the hair cell mechanoelectrical transduction machinery

30 Mar 2017

publication

Bacterial kinesin light chain (Bklc) links the Btub cytoskeleton to membranes.

29 Jan 2017

publication

The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase-like conformation.

31 May 2016

publication

Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38γ.

20 Apr 2016

event

Do not forget the next Citech seminar with Dr Ulf Landegren !

05 Feb 2016

publication

Neurotoxic phospholipase A2 from rattlesnake as a new ligand and new regulator of prokaryotic receptor GLIC (proton-gated ion channel from G. violaceus)

20 Jan 2016

project

SUPERCPLX

20 Nov 2015

project

Biophysical characterization of the translocation process of Bordetella pertussis adenylate cyclase toxin CyaA

18 Nov 2015

project

Molecular crowding

17 Aug 2015

project

CyaA secretion, folding and translocation across membrane

05 May 2015

publication

Deciphering the unconventional peptide binding to the PDZ domain of MAST2

29 Apr 2015

publication

Correction: Two Classes of Bacterial IMPDHs according to Their Quaternary Structures and Catalytic Properties

23 Feb 2015

publication

Two classes of bacterial IMPDHs according to their quaternary structures and catalytic properties

17 Feb 2015

team

Molecular Biophysics

01 Jan 2015

publication

A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation.

30 Dec 2014

publication

Quality assessment and optimization of purified protein samples: why and how?

15 Oct 2014

publication

Structural and functional features of Crl proteins and identification of conserved surface residues required for interaction with the RpoS/σS subunit of RNA polymerase

02 Oct 2014

publication

Community-acquired meticillin-resistant Staphylococcus aureus strain USA300 resists staphylococcal protein A modulation by antibiotics and antimicrobial peptides

01 Oct 2014

publication

Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members.

30 Sep 2014

publication

Regulation of the catalytic activity of the human phosphatase PTPN4 by its PDZ domain.

06 Jun 2014

publication

Assembly of the respiratory mucin MUC5B: a new model for a gel-forming mucin.

11 Apr 2014

publication

Interaction of a partially disordered antisigma factor with its partner, the signaling domain of the TonB-dependent transporter HasR

15 Jan 2014

publication

Extracellular nucleotide catabolism by the Group B Streptococcus ectonucleotidase NudP increases bacterial survival in blood

07 Oct 2013

publication

Two-sided ubiquitin binding of NF-κB essential modulator (NEMO) zinc finger unveiled by a mutation associated with anhidrotic ectodermal dysplasia with immunodeficiency syndrome

07 May 2013

publication

The carboxy-terminal αN helix of the archaeal XerA tyrosine recombinase is a molecular switch to control site-specific recombination

02 May 2013

publication

MgATP regulates allostery and fiber formation in IMPDHs

30 Apr 2013

publication

Hydrodynamic characterization of recombinant human fibrinogen species

30 Jan 2013

publication

The α-helical regions of KERP1 are important in Entamoeba histolytica adherence to human cells

12 Jul 2012

publication

Structural basis for the ABO blood-group dependence of Plasmodium falciparum rosetting

09 May 2012

publication

A S-adenosylmethionine methyltransferase-like domain within the essential, Fe-S-containing yeast protein Dre2

01 Dec 2011

publication

The orientation of the C-terminal domain of the Saccharomyces cerevisiae Rap1 protein is determined by its binding to DNA

01 Dec 2011

publication

Assembly and proteolytic processing of mycobacterial ClpP1 and ClpP2

30 Aug 2011

publication

Outer membrane targeting of secretin PulD protein relies on disordered domain recognition by a dedicated chaperone

25 Sep 2010

publication

Structural characterization of the stem-stem dimerization interface between prolactin receptor chains complexed with the natural hormone

20 Apr 2010

publication

Analysis of the Escherichia coli glucosamine-6-phosphate synthase activity by isothermal titration calorimetry and differential scanning calorimetry

01 Mar 2010

publication

Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA

19 Jan 2010

publication

Calmodulin-induced conformational and hydrodynamic changes in the catalytic domain of Bordetella pertussis adenylate cyclase toxin

06 Jan 2010

publication

Crystal structure of an affinity-matured prolactin complexed to its dimerized receptor reveals the topology of hormone binding site 2

04 Jan 2010

publication

Biochemical and biophysical characterisation of DBL1alpha1-varO, the rosetting domain of PfEMP1 from the VarO line of Plasmodium falciparum

13 Nov 2009

publication

Crystal structure of the extracellular domain of a bacterial ligand-gated ion channel

24 Oct 2009

publication

Comparative structural studies of two natural isoforms of ammodytoxin, phospholipases A2 from Vipera ammodytes ammodytes which differ in neurotoxicity and anticoagulant activity

23 Oct 2009

publication

DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding

30 Jul 2009

publication

The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4

17 Jun 2009

publication

Structure, function, and targets of the transcriptional regulator SvtR from the hyperthermophilic archaeal virus SIRV1

17 Nov 2008

publication

RTX calcium binding motifs are intrinsically disordered in the absence of calcium: implication for protein secretion

29 Oct 2008

publication

The CymR regulator in complex with the enzyme CysK controls cysteine metabolism in Bacillus subtilis

03 Oct 2008

publication

Heparan sulfate regulates fibrillin-1 N- and C-terminal interactions.

01 May 2008

publication

Biomolecular analysis of elastic fibre molecules.

20 Oct 2006

publication

Marfan syndrome-causing mutations in fibrillin-1 result in gross morphological alterations and highlight the structural importance of the second hybrid domain.

01 Aug 2003

publication

Calcium-dependent protein interactions in MUC5B provide reversible cross-links in salivary mucus.

01 Mar 2002

publication

A little guide for advanced search:

Prodomain-driven enzyme dimerization: a pH-dependent autoinhibition mechanism that controls Plasmodium Sub1 activity before merozoite egress.

Acetylation regulates the oligomerization state and activity of RNase J, the Helicobacter pylori major ribonuclease.

Raynals, an online tool for the analysis of dynamic

Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMPDHs.

DNA-binding mechanism and evolution of replication protein A

DNA-binding mechanism and evolution of replication protein A.

The c-di-AMP-binding protein CbpB modulates the level of ppGpp alarmone in Streptococcus agalactiae.

Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity.

Dengue virus NS1 protein conveys pro-inflammatory signals by docking onto high-density lipoproteins.

Deciphering the Molecular Interaction Between the Adhesion G Protein-Coupled Receptor ADGRV1 and its PDZ-Containing Regulator PDZD7.

Actinobacteria challenge the paradigm: A unique protein architecture for a well-known, central metabolic complex.

SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction.

Quality control of protein reagents for the improvement of research data reproducibility.

A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells.

Quality control of purified proteins to improve data quality and reproducibility: results from a large-scale survey.

RNase R is associated in a functional complex with the RhpA DEAD-box RNA helicase in Helicobacter pylori.

PDZ Sample Quality Assessment by Biochemical and Biophysical Characterizations.

Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners.

Structural and functional characterization of the PDZ domain of the human phosphatase PTPN3 and its interaction with the human papillomavirus E6 oncoprotein.

Structural insights into the functional versatility of an FHA domain protein in mycobacterial signaling.

Regulation of measles virus gene expression by P protein coiled-coil properties.

Overall Structures of Mycobacterium tuberculosis DNA Gyrase Reveal the Role of a Corynebacteriales GyrB-Specific Insert in ATPase Activity

Biochemical characterization of the respiratory syncytial virus N0-P complex in solution

Biochemical characterization of the respiratory syncytial virus N-P complex in solution

Characterization of neutralizing antibodies reacting with the 213-224 amino-acid segment of human galectin-9

The stress sigma factor of RNA polymerase RpoS/σ is a solvent-exposed open molecule in solution

Calcium-dependent disorder-to-order transitions are central to the secretion and folding of the CyaA toxin of Bordetella pertussis, the causative agent of whooping cough.

Structural Characterization of Whirlin Reveals an Unexpected and Dynamic Supramodule Conformation of Its PDZ Tandem

Conformational switch of harmonin, a submembrane scaffold protein of the hair cell mechanoelectrical transduction machinery

Bacterial kinesin light chain (Bklc) links the Btub cytoskeleton to membranes.

The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase-like conformation.

Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38γ.

Do not forget the next Citech seminar with Dr Ulf Landegren !

Neurotoxic phospholipase A2 from rattlesnake as a new ligand and new regulator of prokaryotic receptor GLIC (proton-gated ion channel from G. violaceus)

SUPERCPLX

Biophysical characterization of the translocation process of Bordetella pertussis adenylate cyclase toxin CyaA

Molecular crowding

CyaA secretion, folding and translocation across membrane

Deciphering the unconventional peptide binding to the PDZ domain of MAST2

Correction: Two Classes of Bacterial IMPDHs according to Their Quaternary Structures and Catalytic Properties

Two classes of bacterial IMPDHs according to their quaternary structures and catalytic properties

Molecular Biophysics

A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation.

Quality assessment and optimization of purified protein samples: why and how?

Structural and functional features of Crl proteins and identification of conserved surface residues required for interaction with the RpoS/σS subunit of RNA polymerase

Community-acquired meticillin-resistant Staphylococcus aureus strain USA300 resists staphylococcal protein A modulation by antibiotics and antimicrobial peptides

Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members.

Regulation of the catalytic activity of the human phosphatase PTPN4 by its PDZ domain.

Assembly of the respiratory mucin MUC5B: a new model for a gel-forming mucin.

Interaction of a partially disordered antisigma factor with its partner, the signaling domain of the TonB-dependent transporter HasR

Extracellular nucleotide catabolism by the Group B Streptococcus ectonucleotidase NudP increases bacterial survival in blood

Two-sided ubiquitin binding of NF-κB essential modulator (NEMO) zinc finger unveiled by a mutation associated with anhidrotic ectodermal dysplasia with immunodeficiency syndrome

The carboxy-terminal αN helix of the archaeal XerA tyrosine recombinase is a molecular switch to control site-specific recombination

MgATP regulates allostery and fiber formation in IMPDHs

Hydrodynamic characterization of recombinant human fibrinogen species

The α-helical regions of KERP1 are important in Entamoeba histolytica adherence to human cells

Structural basis for the ABO blood-group dependence of Plasmodium falciparum rosetting

A S-adenosylmethionine methyltransferase-like domain within the essential, Fe-S-containing yeast protein Dre2

The orientation of the C-terminal domain of the Saccharomyces cerevisiae Rap1 protein is determined by its binding to DNA

Assembly and proteolytic processing of mycobacterial ClpP1 and ClpP2

Outer membrane targeting of secretin PulD protein relies on disordered domain recognition by a dedicated chaperone

Structural characterization of the stem-stem dimerization interface between prolactin receptor chains complexed with the natural hormone

Analysis of the Escherichia coli glucosamine-6-phosphate synthase activity by isothermal titration calorimetry and differential scanning calorimetry

Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA

Calmodulin-induced conformational and hydrodynamic changes in the catalytic domain of Bordetella pertussis adenylate cyclase toxin

Crystal structure of an affinity-matured prolactin complexed to its dimerized receptor reveals the topology of hormone binding site 2

Biochemical and biophysical characterisation of DBL1alpha1-varO, the rosetting domain of PfEMP1 from the VarO line of Plasmodium falciparum

Crystal structure of the extracellular domain of a bacterial ligand-gated ion channel

Comparative structural studies of two natural isoforms of ammodytoxin, phospholipases A2 from Vipera ammodytes ammodytes which differ in neurotoxicity and anticoagulant activity

DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding

The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4

Structure, function, and targets of the transcriptional regulator SvtR from the hyperthermophilic archaeal virus SIRV1

RTX calcium binding motifs are intrinsically disordered in the absence of calcium: implication for protein secretion

The CymR regulator in complex with the enzyme CysK controls cysteine metabolism in Bacillus subtilis

Heparan sulfate regulates fibrillin-1 N- and C-terminal interactions.

Biomolecular analysis of elastic fibre molecules.

Marfan syndrome-causing mutations in fibrillin-1 result in gross morphological alterations and highlight the structural importance of the second hybrid domain.

Calcium-dependent protein interactions in MUC5B provide reversible cross-links in salivary mucus.

Concentrated solutions of salivary MUC5B mucin do not replicate the gel-forming properties of saliva.