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© Jacob SEELER & Anne DEJEAN, Institut Pasteur
Immunostaining of PML nuclear bodies involved in acute promyelocytic leukemia
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of infectious diseases - 12 Jan 2022

Khalfi P, Suspène R, Caval V, Thiers V, Beauclair G, Marchio A, Bekondi C, Amougou Atsama M, Camengo-Police SM, Noah Noah D, Njouom R, Blanc H, Vallet T, Vignuzzi M, Pineau P, Vartanian JP,

Link to Pubmed [PMID] – 35022749

Link to DOI – 10.1093/infdis/jiac003

J Infect Dis 2022 Jan; ():

A single nucleotide polymorphism in APOBEC3C (serine to isoleucine in position 188) is present in ~10% of African populations and greatly enhances restriction against HIV-1 and SIV by improving dimerization and DNA processivity of the enzyme. In this study, we demonstrated in culture and in infected patients that HBV could be edited by APOBEC3CS188I. Using next generation sequencing, we demonstrated that APOBEC3CS188I led to an enhanced editing activity in a more specific 5’TpCpA->5’TpTpA context. This constitutes a new hallmark of this enzyme which could be used to determine its impact on HBV or nuclear DNA.

https://pubmed.ncbi.nlm.nih.gov/35022749