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© Research
Publication : bioRxiv

Coexistence of state, choice, and sensory integration coding in barrel cortex LII/III

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in bioRxiv - 11 Apr 2023

Pierre-Marie Garderes, Dan Alin Ganea, Sebastien Le Gal, Charly Vincent Rousseau, Alexandre Mamane, Florent Haiss

Link to DOI – https://doi.org/10.1101/2023.04.10.536289

bioRxiv 2023.04.10.536289

During perceptually guided decisions, correlates of choice are found as upstream as in the primary sensory areas. However, how well these choice signals align with early sensory representations, a prerequisite for their interpretation as feedforward substrates of perception, remains an open question. We designed a two alternative forced choice task (2AFC) in which mice compared stimulation frequencies applied to two adjacent vibrissae. The optogenetic silencing of individual columns in the primary somatosensory cortex (wS1) resulted in predicted shifts of psychometric functions, demonstrating that perception depends on focal, early sensory representations. Functional imaging of layer II/III single neurons revealed sensory, choice and engagement coding. From trial to trial, these three varied substantially, but independently from one another. Thus, coding of sensory and non-sensory variables co-exist in orthogonal subspace of the population activity, suggesting that perceptual variability does not originate from wS1 but rather from state or choice fluctuations in downstream areas.