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© Institut Pasteur
Cells infected for 24 hrs with C. Trachomatis. The cell nuclei are labelled in blue, the bacteria appear yellow, within the inclusion lumen. A bacterial protein secreted out the inclusion into the host cytoplasm id labelled in red.

About

Our group has been working on the regulation of central metabolism in mycobacteria, a critical process for Mycobacterium tuberculosis to switch between active growth and dormancy. In collaboration with the teams of Roland Brosch (Institut Pasteur), Helen O’Hare (University of Leicester) and Riccardo Manganelli (University of Padua, Italy), we are focusing on the α-ketoglurate metabolic ‘crossroad’ between carbon and nitrogen metabolism. This key intermediate can be either substrate for the synthesis of glutamate (and then glutamine) via the glutamate dehydrogenase/glutamate synthase network, or can rather be converted, via the Krebs cycle, to succinyl-CoA through the action of the KDH complex (α-ketoglutarate dehydrogenase). We are now mostly working on the structural characterization of a mixed hybrid ‘supercomplex’ between KDH and the related complex of the pyruvate dehydrogenase (PDH), supposedly present in mycobacteria (and possibly the whole Actinobacteria phylum). More details in the relative project page.

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Phone: +33-1-45688608
Email: marco.bellinzoni@pasteur.fr

Address
25-28 Rue du Docteur Roux
75015, Paris
France