Biology of Host-parasite Interactions

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Mise au point d’une méthode de culture in vitro du parasite Plasmodium vivax : VIvax Cycle laboraTORy : VICTOR (2023-031)

Hélène Laude (PI)

VICTOR est une demande d’utilisation d’échantillons collectés dans le cadre de la cohorte COSIPOP. Quel est l’objectif ? L’objectif de cette recherche est de mettre au point une méthode de culture in vitro de […]

Liliana Mancio Silva (PI)

Host parasite metabolic interactions

In this research project, we seek to understand whether malaria-causing Plasmodium parasites i) use sensing mechanisms to select the hepatocyte where its replication will unfold and/or ii) promote host metabolic reprogramming upon invasion of […]

EpiKillMal- Use of DNA methyltransferase inhibitors to kill drug-resistant malaria parasites –

Paola Arimondo (PI)

Malaria remains a major global health problem due to the increasing spread of drug resistance and more than 400,000 deaths per year. New drugs that target multidrug resistant parasites are of highest priority. The […]

Targeting Malaria Epigenetics

Ludovic Halby (PI)

Malaria is a tropical disease due to a parasite named Plasmodium. It is a global health problem, still causing more than 450.000 deaths each year (mostly African children) and over 200 million infections (http://www.who.int/malaria/en/). […]

Completed

4 Members

Plasmodium vivax Invasion Pathways into Human Reticulocytes

Didier Ménard (PI)

Erythrocyte invasion is a complex process involving multiple interactions between Plasmodium merozoites and host erythrocytes. Unlike P. falciparum, which can use multiple erythrocyte receptors for invasion and has merozoite proteins with overlapping and redundant […]

12 Members

Alkoxypyrazoles, inhibitors of dihydroorotate dehydrogenase (DHODH)

Yves Janin (PI)

A thousand fold improvement of an antiviral activity The starting point of this project was the modest activity displayed by compounds 1 and 2, on the phenotypic Measles-based antiviral assay designed by Pierre-Olivier Vidalain […]

P. berghei, a rodent malaria model to investigate host-parasite interactions central for malaria pathogenesis

During the past year, using a murine model for experimental cerebral malaria (ECM), we pursued our investigation regarding the contribution of the allergic inflammatory response in the pathogenesis of malaria disease. Following the demonstration […]

3 Members

Identification of parasite co-factors that are critical for adhesion of P. falciparum–infected RBC

Although PfEMP1/var is studied in many laboratories in the world, a number of key questions remain unknown. By analysing a mutant parasite (D10) with a chromosome 9 deletion and loss of adhesion, we linked […]

4 Members

Targeting epigenetic factors for new intervention strategies

Our basic research on virulence gene control revealed that epigenetic factors such as histone methylation control antigenic variation but also the developmental progression of malaria parasites during the complex life cycle in the […]

2 Members

Nuclear biology and the identification of novel chromatin factors linked to the control of virulence gene expression and genome variability

Fig. 2: Transmission electron micrograph of an iRBC (schizont). Nucleus shown in blue. Only few factors that interact with the DNA of P. falciparum have been identified and the recruitment of specific factors […]

2 Members

Molecular mechanism of antigenic variation of P. falciparum

The protozoan pathogen P. falciparum undergoes antigenic variation to establish persistent blood stage infection. Several clonally variant gene families undergo antigenic variation in P. falciparum and are expressed during blood stage infection at […]

ongoing

1 Member

From basic research to new intervention strategies against malaria parasites