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© Liliana Mancio, Institut Pasteur
Primary human hepatocytes co-cultured with parenchymal cells at 6 days post-seeding. The expression of human CD81 is depicted in pink
Publication : iScience

Plasmodium sporozoites require the protein B9 to invade hepatocytes.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in iScience - 17 Feb 2023

Fernandes P, Loubens M, Marinach C, Coppée R, Baron L, Grand M, Andre TP, Hamada S, Langlois AC, Briquet S, Bun P, Silvie O,

Link to Pubmed [PMID] – 36761022

Link to DOI – 10605610.1016/j.isci.2023.106056

iScience 2023 Feb; 26(2): 106056

Plasmodium sporozoites are transmitted to a mammalian host during blood feeding by an infected mosquito and invade hepatocytes for initial replication of the parasite into thousands of erythrocyte-invasive merozoites. Here we report that the B9 protein, a member of the 6-cysteine domain protein family, is secreted from sporozoite micronemes and is required for productive invasion of hepatocytes. The N-terminus of B9 forms a beta-propeller domain structurally related to CyRPA, a cysteine-rich protein forming an essential invasion complex in Plasmodium falciparum merozoites. The beta-propeller domain of B9 is essential for sporozoite infectivity and interacts with the 6-cysteine proteins P36 and P52 in a heterologous expression system. Our results suggest that, despite using distinct sets of parasite and host entry factors, Plasmodium sporozoites and merozoites may share common structural modules to assemble protein complexes for invasion of host cells.