EpiKillMal- Use of DNA methyltransferase inhibitors to kill drug-resistant malaria parasites –
Malaria remains a major global health problem due to the increasing spread of drug resistance and more than 400,000 deaths per year. New drugs that target multidrug resistant parasites are of highest priority. The […]
Targeting Malaria Epigenetics
Malaria is a tropical disease due to a parasite named Plasmodium. It is a global health problem, still causing more than 450.000 deaths each year (mostly African children) and over 200 million infections (http://www.who.int/malaria/en/). […]
Alkoxypyrazoles, inhibitors of dihydroorotate dehydrogenase (DHODH)
A thousand fold improvement of an antiviral activity The starting point of this project was the modest activity displayed by compounds 1 and 2, on the phenotypic Measles-based antiviral assay designed by Pierre-Olivier Vidalain […]
P. berghei, a rodent malaria model to investigate host-parasite interactions central for malaria pathogenesis
During the past year, using a murine model for experimental cerebral malaria (ECM), we pursued our investigation regarding the contribution of the allergic inflammatory response in the pathogenesis of malaria disease. Following the demonstration […]
Identification of parasite co-factors that are critical for adhesion of P. falciparum–infected RBC
Although PfEMP1/var is studied in many laboratories in the world, a number of key questions remain unknown. By analysing a mutant parasite (D10) with a chromosome 9 deletion and loss of adhesion, we linked […]
Targeting epigenetic factors for new intervention strategies
Our basic research on virulence gene control revealed that epigenetic factors such as histone methylation control antigenic variation but also the developmental progression of malaria parasites during the complex life cycle in the […]
Nuclear biology and the identification of novel chromatin factors linked to the control of virulence gene expression and genome variability
Fig. 2: Transmission electron micrograph of an iRBC (schizont). Nucleus shown in blue. Only few factors that interact with the DNA of P. falciparum have been identified and the recruitment of specific factors […]
Molecular mechanism of antigenic variation of P. falciparum
The protozoan pathogen P. falciparum undergoes antigenic variation to establish persistent blood stage infection. Several clonally variant gene families undergo antigenic variation in P. falciparum and are expressed during blood stage infection at […]
From basic research to new intervention strategies against malaria parasites
The Leitmotif of the BIHP research group can be summarized as follows: “From basic research to new intervention strategies against malaria parasites”. The teams investigate various topics related to blood stage infection such as […]
2017CRISPR/Cas9 Genome Editing Reveals That the Intron Is Not Essential for var2csa Gene Activation or Silencing in Plasmodium falciparum, mBio. 2017 8(4):e00729-17.
2015Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH), J. Med. Chem. 2015 Jul;58(14):5579-98.
2015Flexible guide-RNA design for CRISPR applications using Protospacer Workbench, Nat. Biotechnol. 2015 Aug;33(8):805-6.
2015Post-translational protein modifications in malaria parasites, Nat. Rev. Microbiol. 2015 Mar;13(3):160-72.
2014Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans, Antimicrob. Agents Chemother. 2015 Feb;59(2):950-9.
2014P. berghei telomerase subunit TERT is essential for parasite survival, PLoS ONE 2014;9(9):e108930.
2014Noncoding RNAs as emerging regulators of Plasmodium falciparum virulence gene expression, Curr. Opin. Microbiol. 2014 Aug;20:153-61.
2014Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria, Nature 2014 Sep;513(7518):431-5.
2014Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system, Nat. Biotechnol. 2014 Aug;32(8):819-21.
2014Strand-specific RNA-Seq reveals widespread and developmentally regulated transcription of natural antisense transcripts in Plasmodium falciparum, BMC Genomics 2014;15:150.
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