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  • Undergraduate Student
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  • Director of Center
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© Artur Scherf
Scanning Electron Microscopy of Red Blood Cell infected by Plasmodium falciparum.

Projects

Project
Ongoing
6 Members

EpiKillMal- Use of DNA methyltransferase inhibitors to kill drug-resistant malaria parasites –

Paola Arimondo (PI)

Malaria remains a major global health problem due to the increasing spread of drug resistance and more than 400,000 deaths per year. New drugs that target multidrug resistant parasites are of highest priority. The […]
Project
Ongoing
6 Members

Targeting Malaria Epigenetics

Ludovic Halby (PI)

Malaria is a tropical disease due to a parasite named Plasmodium. It is a global health problem, still causing more than 450.000 deaths each year (mostly African children) and over 200 million infections (http://www.who.int/malaria/en/). […]
Project
Ongoing
12 Members

Alkoxypyrazoles, inhibitors of dihydroorotate dehydrogenase (DHODH)

Yves Janin (PI)

A thousand fold improvement of an antiviral activity The starting point of this project was the modest activity displayed by compounds 1 and 2, on the phenotypic Measles-based antiviral assay designed by Pierre-Olivier Vidalain […]
Project
Ongoing
6 Members

P. berghei, a rodent malaria model to investigate host-parasite interactions central for malaria pathogenesis

Artur Scherf (PI)

During the past year, using a murine model for experimental cerebral malaria (ECM), we pursued our investigation regarding the contribution of the allergic inflammatory response in the pathogenesis of malaria disease. Following the demonstration […]
Project
Ongoing
3 Members

Identification of parasite co-factors that are critical for adhesion of P. falciparum–infected RBC

Artur Scherf (PI)

Although PfEMP1/var is studied in many laboratories in the world, a number of key questions remain unknown. By analysing a mutant parasite (D10) with a chromosome 9 deletion and loss of adhesion, we linked […]
Project
Ongoing
4 Members

Targeting epigenetic factors for new intervention strategies

Artur Scherf (PI)

  Our basic research on virulence gene control revealed that epigenetic factors such as histone methylation control antigenic variation but also the developmental progression of malaria parasites during the complex life cycle in the […]
Project
Ongoing
2 Members

Nuclear biology and the identification of novel chromatin factors linked to the control of virulence gene expression and genome variability

Artur Scherf (PI)

  Fig. 2: Transmission electron micrograph of an iRBC (schizont). Nucleus shown in blue. Only few factors that interact with the DNA of P. falciparum have been identified and the recruitment of specific factors […]
Project
Ongoing
2 Members

Molecular mechanism of antigenic variation of P. falciparum

Artur Scherf (PI)

  The protozoan pathogen P. falciparum undergoes antigenic variation to establish persistent blood stage infection. Several clonally variant gene families undergo antigenic variation in P. falciparum and are expressed during blood stage infection at […]
Project
ongoing
1 Member

From basic research to new intervention strategies against malaria parasites

Artur Scherf (PI)

The Leitmotif of the BIHP research group can be summarized as follows: “From basic research to new intervention strategies against malaria parasites”. The teams investigate various topics related to blood stage infection such as […]

Publications

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