Structure Content

Recipient: Gerald Spaeth, coordinator Agency: Campus France, MEAE, Type: Bi-national program France/Israel, 04/2018 – 03/2020  Leishmaniasis is among the five most serious parasitic diseases worldwide. The cutaneous form of the disease is prevalent in […]

Gerald Spaeth, coordinator and PI Eric Prina, co-PI Manfred Jung (University of Freiburg, Germany), collaborator Dysregulation of epigenetic control has been recognized as a major source of human disease, ranging from cancer to microbial […]

Gerald Spaeth, PI and co-coordinator Narissara Jariyapan (Chulalongkorn University, Bangkok, Thailand), PI and co-coordinator Leishmaniasis in humans is caused by at least 21 species of Leishmania parasites via sand fly bites. Infection results in […]

Gerald Spaeth, PI and co-coordinator Aida Bouratbine (IP Tunis), PI and co-coordinator Les pathologies cutanées et viscérales causées par Leishmania infantum représentent un problème majeur de santé publique dans tous les pays du Maghreb […]

Microtubules are cytoskeletal elements that are central to cell life. Their primary components are tubulins and undergo various post-translational modifications acting as a tubulin code. Here, we wish to investigate a main modification called […]

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Centrosomes (Cs) are the main microtubule organizing centers of many eukaryotic cells with critical roles in cell division, polarity, signaling and structure. Centrioles can act as basal bodies (BB), nucleating microtubules to form cilia […]

VICTOR est une demande d’utilisation d’échantillons collectés dans le cadre de la cohorte COSIPOP. Quel est l’objectif ? L’objectif de cette recherche est de mettre au point une méthode de culture in vitro de […]

Gerald Spaeth, PI Pascale Pescher, co-PI Mariana Boité (Fiocruz Rio de Janeiro, Brazil), coordinator American Visceral Leishmaniasis (AVL) is a persistent public health challenge in the Americas, representing one of the main failures of […]

Developing a SHERLOCK platform for multipurpose detection of trypanosomatid Parasites   Neglected tropical diseases caused by vector-born trypanosomatids – African trypanosomiases, Chagas disease and leishmaniases – affect both humans and animals, and disproportionately levy an […]

Glycerol, a new key player in the trypanosome parasite cycle Trypanosoma brucei is an extracellular parasite responsible for sleeping sickness in Africa and transmitted by a blood-feeding insect vector, the tsetse fly. In its […]

Sorry, this entry is only available in FR.

Sorry, this entry is only available in FR.

Sorry, this entry is only available in FR.

Sorry, this entry is only available in FR.

AdipoTryp Trypanosoma brucei is a unicellular and extracellular parasite transmitted by the tsetse fly (Glossina genus) and causing Human African Trypanosomiasis (HAT) in Sub-Saharan Africa. If untreated, this neglected tropical disease has a case […]

A thousand fold improvement of an antiviral activity The starting point of this project was the modest activity displayed by compounds 1 and 2, on the phenotypic Measles-based antiviral assay designed by Pierre-Olivier Vidalain […]

The interaction between two eukaryotic genomes provides a fascinating example of co-evolution of host-parasite interactions. Two genomes, two epigenomes, two cellular systems living together. Our proposal focuses on the fascinating features of the interaction […]

Intracellular parasitism is a major hallmark of the most successful and deadly human pathogens. This microbial survival strategy is especially devastating if immune cells are exploited as hosts. Here we propose to use the […]

The protozoan parasite Leishmania donovani causes fatal visceral leishmaniasis, one of the most neglected tropical diseases. In the absence of economic incentive, serious Research and Development (R&D) investments into anti-leishmanial drug development lack from […]

Achievement of malaria elimination requires development of novel strategies targeting the parasite sexual stages (gametocytes) to interfer with parasite transmission. The formation of Plasmodium falciparum gametocytes in the human host takes several days in which immature gametocyte-infected […]

We propose to focus on deciphering the mechanistic underpinnings of intracellular replication, as a prominent source of pathogenesis. In particular, given its fundamental role in orchestrating central events to apicomplexan cell division, and flagellar […]

The goal of this project, funded by the Labex GrEX, is to decipher the interactions of Plasmodium falciparum gametocytes with erythroblastic islands, and to analyze the role of P. falciparum adhesins and of erythroblastic […]

Context. Immature gametocytes are sequestered in the deep vasculature while mature gametocytes circulate in the peripheral blood. Mature gametocytes are thus exposed to the fine mechanical sensing displayed by the human spleen, which constantly […]

Dynamics of the early steps of mammalian host infection by African trypanosomes Human African Trypanosomiasis or sleeping sickness is a neglected tropical disease caused by the flagellated protist Trypanosoma brucei. Nagana is a similar […]

Malaria remains a major global health problem due to the increasing spread of drug resistance and more than 400,000 deaths per year. New drugs that target multidrug resistant parasites are of highest priority. The […]

Malaria parasite infection in humans has been called “the strongest known force for evolutionary selection in the recent history of the human genome”, and we hypothesize that a similar statement may apply to the […]

We will employ a target-based strategy for the development of novel drug leads against epigenetic targets in schistosomiasis, leishmaniasis, Chagas disease and malariafocusing on key histone modifying enzymes (HME), in particular those involved in […]

Visceral leishmaniasis is caused by the protozoan parasites Leishmania donovani and Leishmania infantum and is a potentially fatal disease in endemic areas around the world. During the infectious cycle, Leishmania alternate between the insect […]

The Leitmotif of the BIHP research group can be summarized as follows: “From basic research to new intervention strategies against malaria parasites”. The teams investigate various topics related to blood stage infection such as […]

Non-glycolytic pathways in glycosomes: novel functions for trypanosome development and virulence Trypanosomes and Leishmania spp. are parasitic protozoans responsible for major human diseases, which account for ~24 million persons infected worldwide, with over 600 […]

LeiSHield-MATI forms an international, inter- and multidisciplinary consortium that aims to gain scientific knowledge on parasite-vector-host interaction to allow future development of new therapeutic and preventive measures through research and innovation staff exchange and […]

Although PfEMP1/var is studied in many laboratories in the world, a number of key questions remain unknown. By analysing a mutant parasite (D10) with a chromosome 9 deletion and loss of adhesion, we linked […]

Recipient: Gerald Spaeth, PI Agency: Pasteur Institute, Type: Collaborative grant, 01/2016 – 12/2019 Based on ongoing collaborative actions we propose the creation of an IMU between three teams at IP Paris (G. Spaeth), IP […]

Protozoan parasites of the genus Leishmania generate severe human diseases termed Leishmaniases. Due to their frequency and the severity of certain clinical forms, these diseases represent a major public health problem and limit the […]

Cilia and flagella are found at the surface of most cells of the human body. Their malfunctioning results in ciliopathies, genetic diseases that affect 1 individual out of 400. Their construction relies on intraflagellar […]

The cilium is an important organelle for motility and cellular signaling found on most mammalian cells and on single celled organisms such as the parasite Trypanosoma brucei. Cilia formation requires the process of Intraflagellar […]

  The protozoan pathogen P. falciparum undergoes antigenic variation to establish persistent blood stage infection. Several clonally variant gene families undergo antigenic variation in P. falciparum and are expressed during blood stage infection at […]

2019 – 2023 “Mosquito host barriers driving vector specificity for arbovirus transmission (ArboVEC)” (ANR) PI: Kenneth VERNICK (IP Paris)

  Fig. 2: Transmission electron micrograph of an iRBC (schizont). Nucleus shown in blue. Only few factors that interact with the DNA of P. falciparum have been identified and the recruitment of specific factors […]

During the past year, using a murine model for experimental cerebral malaria (ECM), we pursued our investigation regarding the contribution of the allergic inflammatory response in the pathogenesis of malaria disease. Following the demonstration […]

Erythrocyte invasion is a complex process involving multiple interactions between Plasmodium merozoites and host erythrocytes. Unlike P. falciparum, which can use multiple erythrocyte receptors for invasion and has merozoite proteins with overlapping and redundant […]

This PTR aims to gain novel insight into the nature, the expression, and the regulation of Leishmania virulence factors through the investigation of genetics, transcriptomics, and proteomics differences between (i) virulent and avirulent L. […]

Our proposal aims to decipher novel subversion strategies used by Leishmania (i) to withstand, circumvent or inhibit anti-microbial activities of host macrophages and (ii) to interfere with the induction of Leishmania-specific immune responses. We […]

Our PTR project investigates at the complex interface between the intracellular pathogen Leishmania and its macrophage host cell. We will apply systems-wide analyses to elucidate the molecular mechanisms underlying the reciprocal metabolic relationship between […]

Cilia and flagella are essential eukaryotic organelles composed of an evolutionary conserved structure of 9 doublet microtubules that are similar but not equivalent. We propose that a tubulin post-translational modification called glutamylation could act […]

SHERLOCK4HAT African trypanosomes are transmitted by the bite of the tsetse fly and cause the debilitating, and often fatal, neglected tropical disease sleeping sickness, or Human African Trypanosomiasis (HAT). Trypanosoma brucei gambiense, the parasites […]

An exciting symposium will be organised at the Institut Pasteur on 23rd and 24th November 2015. Web site

  Our basic research on virulence gene control revealed that epigenetic factors such as histone methylation control antigenic variation but also the developmental progression of malaria parasites during the complex life cycle in the […]

Malaria is a tropical disease due to a parasite named Plasmodium. It is a global health problem, still causing more than 450.000 deaths each year (mostly African children) and over 200 million infections (http://www.who.int/malaria/en/). […]

  This is a lattice-like structure that is unique to Euglena and Kinetoplastida protozoa (see picture above). It is tightly attached to the axoneme as only trypsin treatment can separate the two structures. It […]

Trypanosoma brucei gambiense causes chronic Human African Trypanosomiasis. These extra-cellular protist parasites are transmitted by tsetse flies and proliferate in the host blood. We have recently demonstrated that the skin was a major yet […]

  The trypanosome cell African trypanosomes are protozoa (unicellular organisms) belonging to the Kinetoplastida order. They are elongated cells (20-25 µm long, 3-5 µm wide), although certain variations are observed during the life cycle. […]

Deciphering the impact of Plasmodium/Trypanosoma co-infections on the vectorial capacity of Anopheles mosquitoes. Malaria and African trypanosomiasis (AT), also known as sleeping sickness in humans and Nagana in cattle, are two parasitic diseases prevalent […]