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© J.M. Ghigo (Institut Pasteur) and Brigite Arbeille (LBC-ME. Faculté de Médecine de Tours)
Colorized scanning electron microscopy of an E. coli biofilm developing on a glass surface
Publication : The Journal of infectious diseases

pH-mediated potentiation of aminoglycosides kills bacterial persisters and eradicates in vivo biofilms

Team: Genetics of Biofilms
Team: Group: Christophe Beloin
Member: Jean-Marc Ghigo
Member: Hilde De Reuse
Member: Christophe Beloin
Member: Frédéric Fischer
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of infectious diseases - 15 May 2014

Lebeaux D, Chauhan A, Létoffé S, Fischer F, de Reuse H, Beloin C, Ghigo JM

Link to Pubmed [PMID] – 24837402

J. Infect. Dis. 2014 Nov;210(9):1357-66

Limitations in treatment of biofilm-associated bacterial infections are often due to subpopulation of persistent bacteria (persisters) tolerant to high concentrations of antibiotics. Based on the increased aminoglycoside efficiency under alkaline conditions, we studied the combination of gentamicin and the clinically compatible basic amino acid L-arginine against planktonic and biofilm bacteria both in vitro and in vivo.

Projects

Biofilm Tolerance to Antibiotics

 One of the  of the hallmarks of biofilm physiology is its tolerance to a high level of antimicrobials. We are currently investigating the molecular mechanisms that lead to this transient ability to withstand antimicrobial treatments. […]

Fighting biofilms

 Biofilm formation on medical devices is associated with hospital-acquired (nosocomial) infections. Due to biofilms’ high tolerance to antibiotics, classical treatments lack efficacy, and removal of the biofilm-contaminated device is often the only therapeutic option. […]