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  • 2024
    Quentin Leclerc, Audrey Duval, Didier Guillemot, Lulla Opatowski, Laura Temime, Using contact network dynamics to implement efficient interventions against pathogen spread in hospital settings: A modelling study, PLoS Medicine, 2024, 21 (7), pp.e1004433. ⟨10.1371/journal.pmed.1004433⟩.
  • 2024
    Rahbé E, Glaser P, Opatowski L, Modeling the transmission of antibiotic-resistant Enterobacterales in the community: A systematic review., Epidemics 2024 Jun; 48(): 100783.
  • 2024
    Nunes MC, Thommes E, Fröhlich H, Flahault A, Arino J, Baguelin M, Biggerstaff M, Bizel-Bizellot G, Borchering R, Cacciapaglia G, Cauchemez S, Barbier-Chebbah A, Claussen C, Choirat C, Cojocaru M, Commaille-Chapus C, Hon C, Kong J, Lambert N, Lauer KB, Lehr T, Mahe C, Marechal V, Mebarki A, Moghadas S, Niehus R, Opatowski L, Parino F, Pruvost G, Schuppert A, Thiébaut R, Thomas-Bachli A, Viboud C, Wu J, Crépey P, Coudeville L, Redefining pandemic preparedness: Multidisciplinary insights from the CERP modelling workshop in infectious diseases, workshop report., Infect Dis Model 2024 Jun; 9(2): 501-518.
  • 2024
    Duval A, Leclerc QJ, Guillemot D, Temime L, Opatowski L, An algorithm to build synthetic temporal contact networks based on close-proximity interactions data., PLoS Comput Biol 2024 Jun; 20(6): e1012227.
  • 2024
    Henriot P, Buelow E, Petit F, Ploy MC, Dagot C, Opatowski L, Modeling the impact of urban and hospital eco-exposomes on antibiotic-resistance dynamics in wastewaters., Sci Total Environ 2024 May; 924(): 171643.
  • 2024
    Paul Henriot, Elena Buelow, Fabienne Petit, Marie-Cécile Ploy, Christophe Dagot, Lulla Opatowski, Modeling the impact of urban and hospital eco-exposomes on antibiotic-resistance dynamics in wastewaters, Science of the Total Environment, 2024, 924, pp.171643. ⟨10.1016/j.scitotenv.2024.171643⟩.
  • 2024
    Smith DRM, Duval A, Grant R, Abbas M, Harbarth S, Opatowski L, Temime L, Predicting consequences of COVID-19 control measure de-escalation on nosocomial transmission and mortality: a modelling study in a French rehabilitation hospital., J Hosp Infect 2024 May; 147(): 47-55.
  • 2024
    Aleksandra Kovacevic, David Rm Smith, Eve Rahbé, Sophie Novelli, Paul Henriot, Emmanuelle Varon, Robert Cohen, Corinne Levy, Laura Temime, Lulla Opatowski, Exploring factors shaping antibiotic resistance patterns in Streptococcus pneumoniae during the 2020 COVID-19 pandemic., eLife, 2024, 13, pp.e85701. ⟨10.7554/eLife.85701⟩.
  • 2024
    Shirreff G, Huynh BT, Duval A, Pereira LC, Annane D, Dinh A, Lambotte O, Bulifon S, Guichardon M, Beaune S, Toubiana J, Kermorvant-Duchemin E, Chéron G, Cordel H, Argaud L, Douplat M, Abraham P, Tazarourte K, Martin-Gaujard G, Vanhems P, Hilliquin D, Nguyen D, Chelius G, Fraboulet A, , Temime L, Opatowski L, Guillemot D, Assessing respiratory epidemic potential in French hospitals through collection of close contact data (April-June 2020)., Sci Rep 2024 Feb; 14(1): 3702.
  • 2024
    Sophie Novelli, Lulla Opatowski, Carmelite Manto, Delphine Rahib, Xavier de Lamballerie, Josiane Warszawski, Laurence Meyer, On Behalf of The Epicov Study Group, Risk Factors for Community and Intrahousehold Transmission of SARS-CoV-2: Modeling in a Nationwide French Population-Based Cohort Study, the EpiCoV Study, American Journal of Epidemiology, 2024, 193 (1), pp.134-148. ⟨10.1093/aje/kwad174⟩.
  • 2023
    Smith DRM, Chervet S, Pinettes T, Shirreff G, Jijón S, Oodally A, Jean K, Opatowski L, Kernéis S, Temime L, How have mathematical models contributed to understanding the transmission and control of SARS-CoV-2 in healthcare settings? A systematic search and review., J Hosp Infect 2023 Nov; 141(): 132-141.
  • 2023
    Rahbe E, Watier L, Guillemot D, Glaser P, Opatowski L, Determinants of worldwide antibiotic resistance dynamics across drug-bacterium pairs: a multivariable spatial-temporal analysis using ATLAS., Lancet Planet Health 2023 Jul; 7(7): e547-e557.
  • 2023
    Smith DRM, Shirreff G, Temime L, Opatowski L, Collateral impacts of pandemic COVID-19 drive the nosocomial spread of antibiotic resistance: A modelling study., PLoS Med 2023 Jun; 20(6): e1004240.
  • 2023
    Duval A, Opatowski L, Brisse S, , Defining genomic epidemiology thresholds for common-source bacterial outbreaks: a modelling study., Lancet Microbe 2023 Mar; (): .
  • 2023
    Wong A, Barrero Guevara LA, Goult E, Briga M, Kramer SC, Kovacevic A, Opatowski L, Domenech de Cellès M, The interactions of SARS-CoV-2 with cocirculating pathogens: Epidemiological implications and current knowledge gaps., PLoS Pathog 2023 Mar; 19(3): e1011167.
  • 2023
    Bonneault M, Delarocque-Astagneau E, Flauder M, Bogaards JA, Guillemot D, Opatowski L, Thiébaut ACM, , Ability of epidemiological studies to monitor HPV post-vaccination dynamics: a simulation study., Epidemiol Infect 2023 Feb; 151(): e31.
  • 2022
    Jijón S, Al Shafie A, Hassan E, , Temime L, Jean K, El-Kassas M, Estimating the risk of incident SARS-CoV-2 infection among healthcare workers in quarantine hospitals: the Egyptian example., Sci Rep 2022 Nov; 12(1): 19773.
  • 2022
    Haschka T, Vergu E, Roche B, Poletto C, Opatowski L, , Retrospective analysis of SARS-CoV-2 omicron invasion over delta in French regions in 2021-22: a status-based multi-variant model., BMC Infect Dis 2022 Nov; 22(1): 815.
  • 2022
    Harimanana A, Rakotondrasoa A, Rivoarilala LO, Criscuolo A, Opatowski L, Rakotomanana EFN, Herindrainy P, Collard JM, Crucitti T, Huynh BT, Neonatal acquisition of extended-spectrum beta-lactamase-producing Enterobacteriaceae in the community of a low-income country (NeoLIC): protocol for a household cohort study in Moramanga, Madagascar., BMJ Open 2022 Sep; 12(9): e061463.
  • 2022
    Bastard J, Nhung NT, Hien VB, Kiet BT, Temime L, Opatowski L, Carrique-Mas J, Choisy M, , Modelling the impact of antimicrobial use and external introductions on commensal E. coli colistin resistance in small-scale chicken farms of the Mekong delta of Vietnam., Transbound Emerg Dis 2022 Sep; 69(5): e2185-e2194.
  • 2022
    Shirreff G, Zahar JR, Cauchemez S, Temime L, Opatowski L, Measuring Basic Reproduction Number to Assess Effects of Nonpharmaceutical Interventions on Nosocomial SARS-CoV-2 Transmission., Emerg Infect Dis 2022 Jul; 28(7): 1345-1354.
  • 2022
    Bonneault M, Poletto C, Flauder M, Guillemot D, Delarocque-Astagneau E, Thiébaut ACM, Opatowski L, , Contact patterns and HPV-genotype interactions yield heterogeneous HPV-vaccine impacts depending on sexual behaviors: An individual-based model., Epidemics 2022 Jun; 39(): 100584.
  • 2022
    Opatowski L, Temime L, , Contributions of modelling for the control of COVID-19 nosocomial transmission., Anaesth Crit Care Pain Med 2022 Apr; 41(2): 101054.
  • 2022
    Diarra M, Kebir A, Talla C, Barry A, Faye J, Louati D, Opatowski L, Diop M, , White LJ, Loucoubar C, Miled SB, , Non-pharmaceutical interventions and COVID-19 vaccination strategies in Senegal: a modelling study., BMJ Glob Health 2022 02; 7(2): .
  • 2022
    Smith DRM, Duval A, Zahar JR, , Opatowski L, Temime L, Rapid antigen testing as a reactive response to surges in nosocomial SARS-CoV-2 outbreak risk., Nat Commun 2022 Jan; 13(1): 236.
  • 2021
    Bosetti P, Huynh BT, Abdou AY, Sanchez M, Eisenhauer C, Courtejoie N, Accardo J, Salje H, Guillemot D, Moslonka-Lefebvre M, Boëlle PY, Béraud G, Cauchemez S, Opatowski L, , Lockdown impact on age-specific contact patterns and behaviours, France, April 2020., Euro Surveill 2021 12; 26(48): .
  • 2021
    Tran Kiem C, Bosetti P, Paireau J, Crépey P, Salje H, Lefrancq N, Fontanet A, Benamouzig D, Boëlle PY, Desenclos JC, Opatowski L, Cauchemez S, , SARS-CoV-2 transmission across age groups in France and implications for control., Nat Commun 2021 11; 12(1): 6895.
  • 2021
    Ajmal Oodally, Pachka Hammami, Astrid Reilhac, Guillaume Guérineau de Lamérie, Lulla Opatowski, Laura Temime, Hospital-level work organization drives the spread of SARS-CoV-2 within hospitals: insights from a multi-ward model, MedRxiv.
  • 2021
    Smith DR, Temime L, Opatowski L, , Microbiome-pathogen interactions drive epidemiological dynamics of antibiotic resistance: A modeling study applied to nosocomial pathogen control., Elife 2021 09; 10(): .
  • 2021
    Kovacevic A, Eggo RM, Baguelin M, Domenech de Cellès M, Opatowski L, The Impact of Cocirculating Pathogens on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)/Coronavirus Disease 2019 Surveillance: How Concurrent Epidemics May Introduce Bias and Decrease the Observed SARS-CoV-2 Percentage Positivity., J Infect Dis 2022 Jan; 225(2): 199-207.
  • 2021
    David R. M. Smith, Audrey Duval, Jean Ralph Zahar, Lulla Opatowski, Laura Temime, Rapid antigen testing as a reactive public health response to surges in SARS-CoV-2 outbreak risk in healthcare settings, MedRxiv (accepted Nature communication).
  • 2021
    Mauras S, Cohen-Addad V, Duboc G, Dupré la Tour M, Frasca P, Mathieu C, Opatowski L, Viennot L, , Mitigating COVID-19 outbreaks in workplaces and schools by hybrid telecommuting., PLoS Comput Biol 2021 08; 17(8): e1009264.
  • 2021
    Cheysson F, Brun-Buisson C, Opatowski L, Le Fouler L, Caserio-Schönemann C, Pontais I, Guillemot D, Watier L, Outpatient antibiotic use attributable to viral acute lower respiratory tract infections during the cold season in France, 2010-2017, Int J Antimicrob Agents 2021 Jun; 57(6): 106339.
  • 2021
    Smith DRM, Opatowski L, , COVID-19 containment measures and incidence of invasive bacterial disease., Lancet Digit Health 2021 Jun; 3(6): e331-e332.
  • 2021
    Bastard J, Haenni M, Gay E, Glaser P, Madec JY, Temime L, Opatowski L, , Drivers of ESBL-producing Escherichia coli dynamics in calf fattening farms: A modelling study., One Health 2021 Jun; 12(): 100238.
  • 2021
    Paolo Bosetti, Bich-Tram Huynh, Armiya Youssouf Abdou, Marie Sanchez, Catherine Eisenhauer, Noémie Courtejoie, Jérôme Accardo, Henrik Salje, Didier Guillemot, Mathieu Moslonka-Lefebvre, Pierre-Yves Boëlle, Guillaume Béraud, Simon Cauchemez, Lulla Opatowski, Lockdown impact on age-specific contact patterns and behaviours in France (accepted), Eurosurveillance.
  • 2021
    Domenech de Cellès M, Casalegno JS, Lina B, Opatowski L, , Estimating the impact of influenza on the epidemiological dynamics of SARS-CoV-2., PeerJ 2021 ; 9(): e12566.
  • 2020
    Smith DRM, Duval A, Pouwels KB, Guillemot D, Fernandes J, Huynh BT, Temime L, Opatowski L, , , Optimizing COVID-19 surveillance in long-term care facilities: a modelling study., BMC Med 2020 12; 18(1): 386.
  • 2020
    Opatowski L, Opatowski M, Vong S, Temime L, , A One-Health Quantitative Model to Assess the Risk of Antibiotic Resistance Acquisition in Asian Populations: Impact of Exposure Through Food, Water, Livestock and Humans., Risk Anal 2020 Oct; (): .
  • 2020
    Nekkab N, Crépey P, Astagneau P, Opatowski L, Temime L, , Assessing the role of inter-facility patient transfer in the spread of carbapenemase-producing Enterobacteriaceae: the case of France between 2012 and 2015., Sci Rep 2020 09; 10(1): 14910.
  • 2020
    Matthieu Domenech de Cellès, Jean-Sébastien Casalegno, Bruno Lina, Lulla Opatowski, Influenza may facilitate the spread of SARS-CoV-2, MedRxiv.
  • 2020
    Salje H, Tran Kiem C, Lefrancq N, Courtejoie N, Bosetti P, Paireau J, Andronico A, Hozé N, Richet J, Dubost CL, Le Strat Y, Lessler J, Levy-Bruhl D, Fontanet A, Opatowski L, Boelle PY, Cauchemez S, , Estimating the burden of SARS-CoV-2 in France., Science 2020 07; 369(6500): 208-211.
  • 2020
    Temime L, Gustin MP, Duval A, Buetti N, Crépey P, Guillemot D, Thiébaut R, Vanhems P, Zahar JR, Smith DRM, Opatowski L, , A Conceptual Discussion About the Basic Reproduction Number of Severe Acute Respiratory Syndrome Coronavirus 2 in Healthcare Settings., Clin Infect Dis 2021 01; 72(1): 141-143.
  • 2020
    Domenech de Cellès M, Campbell H, Borrow R, Taha MK, Opatowski L, , Transmissibility and pathogenicity of the emerging meningococcal serogroup W sequence type-11 complex South American strain: a mathematical modeling study., BMC Med 2020 Apr; 18(1): 109.
  • 2020
    Bastard J, Andraud M, Chauvin C, Glaser P, Opatowski L, Temime L, Dynamics of livestock-associated methicillin resistant Staphylococcus aureus in pig movement networks: Insight from mathematical modeling and French data, Epidemics 2020 Feb;31:100389.
  • 2019
    Alari A, Cheysson F, Le Fouler L, Lanotte P, , Varon E, Opatowski L, Guillemot D, Watier L, Association of Pneumococcal Conjugate Vaccine Coverage With Pneumococcal Meningitis: An Analysis of French Administrative Areas, 2001-2016, Am. J. Epidemiol. 2019 Aug;188(8):1466-1474.
  • 2019
    Bonneault M, Andrianoelina VH, Herindrainy P, Rabenandrasana MAN, Garin B, Breurec S, Delarocque-Astagneau E, Guillemot D, Andrianirina ZZ, Collard JM, Huynh BT, Opatowski L, Transmission Routes of Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae in a Neonatology Ward in Madagascar., Am J Trop Med Hyg 2019 Jun; 100(6): 1355-1362.
  • 2019
    Duval A, Obadia T, Boëlle PY, Fleury E, Herrmann JL, Guillemot D, Temime L, Opatowski L, , Close proximity interactions support transmission of ESBL-K. pneumoniae but not ESBL-E. coli in healthcare settings, PLoS Comput. Biol. 2019 05;15(5):e1006496.
  • 2019
    Domenech de Cellès M, Arduin H, Lévy-Bruhl D, Georges S, Souty C, Guillemot D, Watier L, Opatowski L, Unraveling the seasonal epidemiology of pneumococcus, Proc. Natl. Acad. Sci. U.S.A. 2019 01;116(5):1802-1807.
  • 2018
    Gao X, Huynh BT, Guillemot D, Glaser P, Opatowski L, Inference of Significant Microbial Interactions From Longitudinal Metagenomics Data, Front Microbiol 2018;9:2319.
  • 2018
    Opatowski L, Baguelin M, Eggo RM, Influenza interaction with cocirculating pathogens and its impact on surveillance, pathogenesis, and epidemic profile: A key role for mathematical modelling, PLoS Pathog. 2018 02;14(2):e1006770.
  • 2017
    Rosello A, Pouwels KB, Domenech DE Cellès M, VAN Kleef E, Hayward AC, Hopkins S, Robotham JV, Smieszek T, Opatowski L, Deeny SR, Seasonality of urinary tract infections in the United Kingdom in different age groups: longitudinal analysis of The Health Improvement Network (THIN), Epidemiol. Infect. 2018 01;146(1):37-45.
  • 2017
    Opatowski L, Baguelin M, Eggo R, Influenza Interaction with Cocirculating Pathogens, and Its Impact on Surveillance, Pathogenesis and Epidemic Profile: A Key Role for Mathematical Modeling (accepted PLOS Pathogens), bioRxiv. 2017. doi: https://doi.org/10.1101/203265.
  • 2017
    Chéreau F, Opatowski L, Tourdjman M, Vong S., Risk Assessment for Antibiotic Resistance in South-East Asia, BMJ 2017;358:j3393.
  • 2017
    Domenech de Cellès M, Arduin H, Varon E, Souty C, Boëlle PY, Lévy-Bruhl D, van der Werf S, Soulary JC, Guillemot D, Watier L, Opatowski L, Characterizing and Comparing the Seasonality of Influenza-Like Illnesses and Invasive Pneumococcal Diseases Using Seasonal Waveforms, Am. J. Epidemiol. 2018 05;187(5):1029-1039.
  • 2017
    Assab R, Nekkab N, Crépey P, Astagneau P, Guillemot D, Opatowski L, Temime L., Mathematical models of infection transmission in healthcare settings: recent advances from the use of network structured data., Curr Opin Infect Dis. 2017 Aug;30(4):410-418. doi: 10.1097/QCO.0000000000000390..
  • 2017
    Arduin H, Domenech de Cellès M, Guillemot D, Watier L, Opatowski L., An agent-based model simulation of influenza interactions at the host level: insight into the influenza-related burden of pneumococcal infections, BMC Infect Dis. 2017 Jun 2;17(1):382. doi: 10.1186/s12879-017-2464-z.
  • 2016
    Alari A, Chaussade H, Domenech De Cellès M, Le Fouler L, Varon E, Opatowski L, Guillemot D, Watier L., Impact of pneumococcal conjugate vaccines on pneumococcal meningitis cases in France between 2001 and 2014: a time series analysis., BMC Med. 2016 Dec 21;14(1):211. doi: 10.1186/s12916-016-0755-7..
  • 2015
    de Cellès MD, Pons-Salort M, Varon E, Vibet MA, Ligier C, Letort V, Opatowski L, Guillemot D, Interaction of Vaccination and Reduction of Antibiotic Use Drives Unexpected Increase of Pneumococcal Meningitis., Sci Rep. 2015 Jun 11;5:11293. doi: 10.1038/srep11293.
  • 2015
    Obadia T, Opatowski L, Temime L, Herrmann JL, Fleury É, Boëlle PY, Guillemot D, Interindividual Contacts and Carriage of Methicillin-Resistant Staphylococcus aureus: A Nested Case-Control Study, Infect Control Hosp Epidemiol 2015 Aug;36(8):922-9.
  • 2015
    Obadia T, Silhol R, Opatowski L, Temime L, Legrand J, Thiébaut AC, Herrmann JL, Fleury É, Guillemot D, Boëlle PY; I-Bird Study Group, Detailed contact data and the dissemination of Staphylococcus aureus in hospitals, PLoS Comput Biol. 2015 Mar 19;11(3):e1004170. doi: 10.1371/journal.pcbi.1004170. eCollection 2015..
  • 2014
    Jombart T, Aanensen DM, Baguelin M, Birrell P, Cauchemez S, Camacho A, Colijn C, Collins C, Cori A, Didelot X, Fraser C, Frost S, Hens N, Hugues J, Höhle M, Opatowski L, Rambaut A, Ratmann O, Soubeyrand S, Suchard MA, Wallinga J, Ypma R, Ferguson N., OutbreakTools: a new platform for disease outbreak analysis using the R software, Epidemics. 2014 Jun;7:28-34.
  • 2014
    Pons-Salort M, Serra-Cobo J, Jay F, López-Roig M, Lavenir R, Guillemot D, Letort V, Bourhy H, Opatowski L, Insights into persistence mechanisms of a zoonotic virus in bat colonies using a multispecies metapopulation model, PLoS ONE 2014;9(4):e95610.
  • 2013
    Opatowski L, Varon E, Dupont C, Temime L, van der Werf S, Gutmann L, Boëlle PY, Watier L, Guillemot D, Assessing pneumococcal meningitis association with viral respiratory infections and antibiotics: insights from statistical and mathematical models, Proc. Biol. Sci. 2013 Aug;280(1764):20130519.
  • 2011
    Kardas-Sloma L, Boëlle PY, Opatowski L, Brun-Buisson C, Guillemot D, Temime L., Impact of antibiotic exposure patterns on selection of community-associated methicillin-resistant Staphylococcus aureus in hospital settings, Antimicrob Agents Chemother. 2011 Oct;55(10):4888-95..
  • 2011
    Opatowski L, Fraser C, Griffin J, de Silva E, Van Kerkhove MD, Lyons EJ, Cauchemez S, Ferguson NM., Transmission characteristics of the 2009 H1N1 influenza pandemic: comparison of 8 Southern hemisphere countries., PLoS Pathog. 2011 Sep;7(9):e1002225.
  • 2011
    Domenech de Cellès M, Opatowski L, Salomon J, Varon E, Carbon C, Boëlle PY, Guillemot D, Intrinsic epidemicity of Streptococcus pneumoniae depends on strain serotype and antibiotic susceptibility pattern, Antimicrob. Agents Chemother. 2011 Nov;55(11):5255-61.
  • 2011
    Opatowski L, Guillemot D, Boëlle PY, Temime L., Contribution of mathematical modeling to the fight against bacterial antibiotic resistance, Curr Opin Infect Dis. 2011 Jun;24(3):279-87..
  • 2010
    Kardas-Sloma L, Boëlle PY, Opatowski L, Guillemot D, Temime L., Antibiotic reduction campaigns do not necessarily decrease bacterial resistance: the example of methicillin-resistant Staphylococcus aureus, Antimicrob Agents Chemother. 2013 Sep;57(9):4410-6..
  • 2010
    Opatowski L, Mandel J, Varon E, Boëlle PY, Temime L, Guillemot D., Antibiotic dose impact on resistance selection in the community: a mathematical model of beta-lactams and Streptococcus pneumoniae dynamics, Antimicrob Agents Chemother. 2010 Jun;54(6):2330-7.
  • 2010
    Pons-Salort M, Letort V, Favre M, Heard I, Dervaux B, Opatowski L, Guillemot D., Exploring individual HPV coinfections is essential to predict HPV-vaccination impact on genotype distribution: a model-based approach, Vaccine. 2013 Feb 6;31(8):1238-45.
  • 2010
    Temime L, Kardas L, Opatowski L, Brun-Buisson C, Boëll eP-Y. and Guillemot D., NOSOSIM: an agent-based model of pathogen circulation in a hospital ward, International Conference on Computational Science, ICCS 2010. Procedia Computer Science 1. 2010.
  • 2009
    Temime L, Opatowski L, Pannet Y, Brun-Buisson C, Boëlle PY, Guillemot D., Peripatetic health-care workers as potential superspreaders, Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18420-5.
  • 2008
    Temime L, Boelle PY, Opatowski L, Guillemot D., Impact of capsular switch on invasive pneumococcal disease incidence in a vaccinated population, PLoS One. 2008 Sep 19;3(9):e3244.
  • 2008
    Opatowski L, Temime L, Varon E, Leclercq R, Drugeon H, Boëlle PY, Guillemot D., Antibiotic innovation may contribute to slowing the dissemination of multiresistant Streptococcus pneumoniae: the example of ketolides, PLoS One. 2008 May 7;3(5):e2089.
  • 2006
    García-Serna R, Opatowski L, Mestres J., FCP: functional coverage of the proteome by structures, Bioinformatics. 2006 Jul 15;22(14):1792-3..
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