• 2025
  Marcel Hollenstein*, Enzymatic synthesis of RNA oligonucleotides, Nat. Biotechnol. 2025, 43, 691-693.
• 2025
  Debashis Dhara, Laurence A. Mulard, and Marcel Hollenstein*, Natural, modified and conjugated carbohydratesin nucleic acids, Chem. Soc. Rev. 2025, 54, 2948-2983.
• 2025
  Rémi Sieskind, Sophia Missoury, Clément Madru, Isciane Commenge, Germain Niogret, Marcel Hollenstein, Yannick Rondelez, Ludovic Sauguet, Ahmed Haouz, Pierre Legrand, Marc Delarue, Crystal structures of monomeric BsmI restriction endonuclease reveal coordinated sequential cleavage of two DNA strands, Communications Biology, 2025, 8 (1), pp.387. ⟨10.1038/S42003-025-07612-Z⟩.
• 2025
  Pierre Nicolas Bizat, Nazarii Sabat*, Marcel Hollenstein*, Recent Advances in Biocatalytic and Chemoenzymatic Synthesis of Oligonucleotides, ChemBioChem. 2025, 26, e202400987.
• 2024
  Nazarii Sabat, Andreas Stämpfli, Steven Hanlon, Serena Bisagni, Filippo Sladojevich, Kurt Püntener, and Marcel Hollenstein*, Template-dependent DNA ligation for the synthesis of modified oligonucleotides., Nat. Commun. 2024, 15, 8009.
• 2024
  Sabat N, Stämpfli A, Hanlon S, Bisagni S, Sladojevich F, Püntener K, Hollenstein M, Template-dependent DNA ligation for the synthesis of modified oligonucleotides., Nat Commun 2024 Sep; 15(1): 8009.
• 2024
  Germain Niogret, Camille Chériaux, Frédéric Bonhomme, Fabienne Levi-Acobas, Carlotta Figliola, Gilles Ulrich, Gilles Gasser* and Marcel Hollenstein*, A toolbox for enzymatic modification of nucleic acids with photosensitizers for photodynamic therapy, RSC Chem. Biol. 2024, 5, 841-852.
• 2024
  Maëva Pichon and Marcel Hollenstein*, Controlled enzymatic synthesis of oligonucleotides, Commun. Chem. 2024, 7, 138.
• 2023
  Debashis Dhara, Laurence A. Mulard,* Marcel Hollenstein*, Expedient synthesis of l-heptose derived septacidin building blocks from l-glucose, Carbohydr. Res. 2023, 534, 108985.
• 2023
  Nazarii Sabat, Andreas Stämpfli, Marie Flamme, Steven Hanlon, Serena Bisagni, Filippo Sladojevich, Kurt Püntener, and Marcel Hollenstein* , Artificial nucleotide codons for enzymatic DNA synthesis, Chem. Commun., 2023,59, 14547-14550.
• 2023
  Maria Dalla Pozza, Pierre Mesdom, Ahmad Abdullrahman, Tayler D. Prieto Otoya, Philippe Arnoux, Céline Frochot, Germain Niogret, Bruno Saubaméa, Pierre Burckel, James P. Hall, Marcel Hollenstein, Christine J. Cardin, and Gilles Gasser*, Increasing the π-Expansive Ligands in Ruthenium(II) Polypyridyl Complexes: Synthesis, Characterization, and Biological Evaluation for Photodynamic Therapy Applications, Inorg. Chem. 2023, 62, 45, 18510–18523.
• 2023
  Cécile Gasse,* Puneet Srivastava, Guy Schepers, Joachim Jose, Marcel Hollenstein, Philippe Marlière, and Piet Herdewijn*, Controlled E. coli Aggregation Mediated by DNA and XNA Hybridization, ChemBioChem 2023, 24, e202300191.
• 2023
  Sabat N, Katkevica D, Pajuste K, Flamme M, Stämpfli A, Katkevics M, Hanlon S, Bisagni S, Püntener K, Sladojevich F, Hollenstein M*, Towards the controlled enzymatic synthesis of LNA containing oligonucleotides., Front Chem 2023 ; 11(): 1161462.
• 2022
  Chiara Figazzolo, Frédéric Bonhomme, Saidbakhrom Saidjalolov, Mélanie Ethève-Quelquejeu, and Marcel Hollenstein*, Enzymatic Synthesis of Vancomycin-Modified DNA, Molecules 2022, 27, 8927.
• 2022
  Mikaël Boullé,* Laurianne Davignon, Keïs Nabhane Saïd Halidi, Salomé Guez, Emilie Giraud, Marcel Hollenstein, and Fabrice Agou*, High-Content RNAi Phenotypic Screening Unveils the Involvement of Human Ubiquitin-Related Enzymes in Late Cytokinesis, Cells 2022, 11(23), 3862.
• 2022
  Chiara Figazzolo, Yifeng Ma, James H. R. Tucker* and Marcel Hollenstein*, Ferrocene as a potential electrochemical reporting surrogate of abasic sites in DNA, Org. Biomol. Chem., 2022, 20, 8125 - 8135.
• 2022
  Kwing Yeung Chan, Andrew Brian Kinghorn, Marcel Hollenstein, and Julian Alexander Tanner, Chemical Modifications for a Next Generation of Nucleic Acid Aptamers, ChemBioChem 2022, 23, e202200006.
• 2022
  Flamme, M.; Katkevica, D.; Pajuste, K.; Katkevics, M.; Sabat, N.; Hanlon, S.; Marzuoli, I.; Püntener, K.; Sladojevich, F.; Hollenstein, M., Benzoyl and pivaloyl as efficient protecting groups for controlled enzymatic synthesis of DNA and XNA oligonucleotides, Asian J. Org. Chem. 2022, e202200384.
• 2022
  Marie Flamme, Steven Hanlon, Irene Marzuoli, Kurt Püntener, Filippo Sladojevich and Marcel Hollenstein*, Evaluation of 3′-phosphate as a transient protecting group for controlled enzymatic synthesis of DNA and XNA oligonucleotides, Commun. Chem. 2022, 5, 68.
• 2022
  Flamme M, Hanlon S, Marzuoli I, Püntener K, Sladojevich F, Hollenstein M, Evaluation of 3′-phosphate as a transient protecting group for controlled enzymatic synthesis of DNA and XNA oligonucleotides., Commun Chem 2022 Jun; 5(1): 68.
• 2022
  Fabienne Levi-Acobas, Luke K. McKenzie, and Marcel Hollenstein*, Towards polymerase-mediated synthesis of artificial RNA–DNA metal base pairs, New J. Chem., 2022, 46, 4871-4876.
• 2022
  Luke K. McKenzie‡, Marie Flamme‡, Patrick S. Felder, Johannes Karges, Frederic Bonhomme, Albert Gandioso, Christian Malosse, Gilles Gasser* and Marcel Hollenstein*, A ruthenium-oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy, RSC Chem. Biol., 2022, 3, 85-95.
• 2021
  Fabienne Levi-Acobas, Luke K. McKenzie, Marcel Hollenstein*, Polymerase-mediated synthesis of artificial RNA-DNA metal base pairs, ChemRxiv 2021, 10.26434/chemrxiv-2021-2d0h6.
• 2021
  Luke K. McKenzie, Marie Flamme, Patrick S. Felder, Johannes Karges, Frederic Bonhomme, Albert Gandioso, Christian Malosse, Gilles Gasser, Marcel Hollenstein, A ruthenium-oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy, RSC Chemical Biology.
• 2021
  Luke K. McKenzie, Marie Flamme, Patrick S. Felder, Johannes Karges, Frederic Bonhomme, Albert Gandioso, Christian Malosse, Gilles Gasser*, Marcel Hollenstein*, A ruthenium-oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy, ChemRxiv 2021, 10.33774/chemrxiv-2021-5n9xv.
• 2021
  Marie Flamme, Steven Hanlon, Hans Iding, Kurt Puentener, Filippo Sladojevich, Marcel Hollenstein*, Towards the enzymatic synthesis of phosphorothioate containing LNA oligonucleotides, Bioorg. Med. Chem. Lett. 48 (2021) 128242.
• 2021
  Marie Flamme, Chiara Figazzolo, Gilles Gasser and Marcel Hollenstein∗, Enzymatic construction of metal-mediated nucleic acid base pairs, Metallomics, 2021, 13, mfab016.
• 2021
  Luke K. McKenzie, Roberto El-Khoury, James D. Thorpe, Masad J. Damha* and Marcel Hollenstein*, Recent progress in non-native nucleic acid modifications, Chem. Soc. Rev. 2021, 50, 5126–5164.
• 2021
  Tom Baladi, Jesper R. Nilsson, Audrey Gallud, Emanuele Celauro, Cécile Gasse, Fabienne Levi-Acobas, Ivo Sarac, Marcel R. Hollenstein, Anders Dahlén, Elin K. Esbjörner*, and L. Marcus Wilhelmsson*, Stealth Fluorescence Labeling for Live Microscopy Imaging of mRNA Delivery, J. Am. Chem. Soc. 2021, 143, 5413−5424.
• 2020
  Marie Flamme, Pascal Röthlisberger, Fabienne Levi-Acobas, Mohit Chawla, Romina Oliva, Luigi Cavallo, Gilles Gasser, Philippe Marlière, Piet Herdewijn, and Marcel Hollenstein*, Enzymatic Formation of an Artificial Base Pair Using a Modified Purine Nucleoside Triphosphate, ACS Chem. Biol. 2020, 15, 2872-2884.
• 2020
  Marie Flamme, Fabienne Levi‐Acobas, Susanne Hensel, Shuvankar Naskar, Pascal Röthlisberger, Ivo Sarac, Gilles Gasser, Jens Müller, Marcel Hollenstein*, Enzymatic Construction of Artificial Base Pairs: The Effect of Metal Shielding, ChemBioChem 2020, 21, 3398-3409.
• 2020
  Cheung YW, Röthlisberger P, Mechaly AE, Weber P, Levi-Acobas F, Lo Y, Wong AWC, Kinghorn AB, Haouz A, Savage GP, Hollenstein M*, Tanner JA*, , Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker., Proc. Natl. Acad. Sci. U.S.A. 2020 Jul; (): .
• 2020
  John C. Chaput*, Piet Herdewijn*, Marcel Hollenstein*, Orthogonal Genetic Systems, ChemBioChem 2020, 21, 1408-1411.
• 2020
  Pascal Röthlisberger, Fabienne Levi-Acobas, Christian J. Leumann, Marcel Hollenstein*, Enzymatic synthesis of biphenyl-DNA oligonucleotides, Biorg. Med. Chem. 2020, 28, 115487.
• 2020
  Diego Carnevale*, Marcel Hollenstein, and Geoffrey Bodenhausen, Self‐Assembly of DNA and RNA Building Blocks Explored by Nitrogen‐14 NMR Crystallography: Structure and Dynamics, ChemPhysChem 2020, 21, 1044-1051.
• 2020
  Nancy Soliman, Luke K. McKenzie, Johannes Karges, Emilie Bertrand, Mickaël Tharaud, Marta Jakubaszek, Vincent Guérineau, Bruno Goud, Marcel Hollenstein, Gilles Gasser * and Christophe M. Thomas *, Ruthenium-initiated polymerization of lactide: a route to remarkable cellular uptake for photodynamic therapy of cancer, Chem. Sci., 2020, 11, 2657-2663.
• 2020
  Soliman N, McKenzie LK, Karges J, Bertrand E, Tharaud M, Jakubaszek M, Guérineau V, Goud B, Hollenstein M, Gasser G, Thomas CM, , Ruthenium-initiated polymerization of lactide: a route to remarkable cellular uptake for photodynamic therapy of cancer., Chem Sci 2020 Jan; 11(10): 2657-2663.
• 2019
  Marie Flamme, Pascal Röthlisberger, Fabienne Levi-Acobas, Mohit Chawla, Romina Oliva, Luigi Cavallo, Gilles Gasser, Philippe Marlière, Piet Herdewijn, and Marcel Hollenstein*, Enzymatic Formation of an Artificial Base Pair Using a Modified Adenine Nucleoside Triphosphate, ChemRxiv 2019, doi: 10.26434/chemrxiv.11427459.v1.
• 2019
  Fabienne Levi-Acobas, Pascal Röthlisberger, Ivo Sarac, Philippe Marlière, Piet Herdewijn, and Marcel Hollenstein*, On the Enzymatic Formation of Metal Base Pairs with Thiolated and pKa-Perturbed Nucleotides, ChemBioChem 2019, 20, 3032 – 3040.
• 2019
  Fabienne Levi-Acobas, Adam Katolik, Pascal Röthlisberger, Thomas Cokelaer, Ivo Sarac, Masad J. Damha, Christian J. Leumann and Marcel Hollenstein*, Compatibility of 5-ethynyl-2’F-ANA UTP with in vitro selection for the generation of base-modified, nuclease resistant aptamers, Org. Biomol. Chem. 2019, 17, 8083 - 8087.
• 2019
  Marcel Hollenstein*, Nucleic acid enzymes based on functionalized nucleosides, Curr. Opin. Chem. Biol. 2019, 52, 93-101.
• 2019
  Stella Diafa, Damien Evéquoz, Christian J. Leumann, and Marcel Hollenstein*, Synthesis and Enzymatic Characterization of Sugar-Modified Nucleoside Triphosphate Analogs, Methods Mol. Biol. 2019, 1973, 1-13.
• 2019
  MarieFlamme, Luke K McKenzie, IvoSarac, Marcel Hollenstein*, Chemical methods for the modification of RNA, Methods 2019, 161, 64-82.
• 2019
  Ivo Sarac, Marcel Hollenstein*, Terminal Deoxynucleotidyl Transferase in the Synthesis and Modification of Nucleic Acids, ChemBioChem 2019, 20, 860 – 871.
• 2019
  Pascal Röthlisberger, Fabienne Levi-Acobas, Ivo Sarac, Philippe Marlière, Piet Herdewijn, Marcel Hollenstein*, Towards the enzymatic formation of artificial metal base pairs with a carboxy-imidazole-modified nucleotide, J. Inorg. Biochem. 2019, 191, 154-163.
• 2018
  Pascal Röthlisberger, Fabienne Levi-Acobas, Ivo Sarac, Rémy Ricoux, Jean-Pierre Mahy, Piet Herdewijn, Philippe Marlière, Marcel Hollenstein*, Incorporation of a minimal nucleotide into DNA, Tetrahedron Lett. 2018, 59, 4241-4244.
• 2018
  Kyoung-Ran Kim, Pascal Röthlisberger, Seong Jae Kang, Kihwan Nam, Sangyoup Lee, Marcel Hollenstein, and Dae-Ro Ahn, Shaping Rolling Circle Amplification Products into DNA Nanoparticles by Incorporation of Modified Nucleotides and Their Application to In Vitro and In Vivo Delivery of a Photosensitizer, Molecules 2018, 23, 1833.
• 2018
  Hien Bao Dieu Thai, Fabienne Levi-Acobas, Soo-Young Yum, Goo Jang, Marcel Hollenstein and Dae-Ro Ahn, Tetrahedral DNAzymes for enhanced intracellular gene-silencing activity, Chem. Commun., 2018,54, 9410-9413 .
• 2018
  Pascal Röthlisberger and Marcel Hollenstein*, Aptamer chemistry, Adv. Drug Deliv. Rev. 2018, 134, 3–21.
• 2018
  Marcel Hollenstein*, DNA Synthesis by Primer Exchange Reaction Cascades, ChemBioChem, 2018, 19, 422-424.
• 2017
  S. Diafa, D. Evéquoz, C. J. Leumann, M. Hollenstein, Enzymatic Synthesis of 7’,5’-Bicyclo-DNA Oligonucleotides, Chem. Asian J. 2017, 12, 1347-1352.
• 2017
  Röthlisberger, P.; Fabienne Levi-Acobas, F.; Sarac, I.; Marlière, P.; Herdewijn, P.; Hollenstein, M., On the enzymatic incorporation of an imidazole nucleotide into DNA, Org. Biomol. Chem. 2017, 15, 4449-4455.
• 2017
  Pascal Röthlisberger, Fabienne Levi-Acobas, Marcel Hollenstein, New synthetic route to ethynyl-dUTP: A means to avoid formation of acetyl and chloro vinyl base-modified triphosphates that could poison SELEX experiments, Bioorg. Med. Chem. Lett. 2017, 27, 897-900.
• 2016
  Marcel Hollenstein, Masad J. Damha, Rolling circle amplification with chemically modified nucleoside triphosphates, Curr. Protoc. Nucleic Acid Chem. 2016, 67, 7.26.1-7.26.15.
• 2015
  Hollenstein M, DNA Catalysis: The Chemical Repertoire of DNAzymes, Molecules 2015;20(11):20777-804.
• 2015
  Hollenstein M, Generation of long, fully modified, and serum-resistant oligonucleotides by rolling circle amplification, Org. Biomol. Chem. 2015 Oct;13(38):9820-4.
• 2015
  Diafa S, Hollenstein M, Generation of Aptamers with an Expanded Chemical Repertoire, Molecules 2015;20(9):16643-71.
• 2015
  Räz MH, Hollenstein M, Probing the effect of minor groove interactions on the catalytic efficiency of DNAzymes 8-17 and 10-23, Mol Biosyst 2015 May;11(5):1454-61.
• 2015
  Renders M, Miller E, Hollenstein M, Perrin D, A method for selecting modified DNAzymes without the use of modified DNA as a template in PCR, Chem. Commun. (Camb.) 2015 Jan;51(7):1360-2.
• 2014
  Hollenstein M, Leumann CJ, Synthesis and biochemical characterization of tricyclothymidine triphosphate (tc-TTP), Chembiochem 2014 Sep;15(13):1901-4.
• 2014
  Hollenstein M, Smith CC, Räz M, Nucleoside triphosphates–from synthesis to biochemical characterization, J Vis Exp 2014;(86).
• 2013
  Hollenstein M, Deoxynucleoside triphosphates bearing histamine, carboxylic acid, and hydroxyl residues–synthesis and biochemical characterization, Org. Biomol. Chem. 2013 Aug;11(31):5162-72.
• 2013
  Hollenstein M, Hipolito CJ, Lam CH, Perrin DM, Toward the combinatorial selection of chemically modified DNAzyme RNase A mimics active against all-RNA substrates, ACS Comb Sci 2013 Apr;15(4):174-82.
• 2012
  Hollenstein M, Nucleoside triphosphates–building blocks for the modification of nucleic acids, Molecules 2012;17(11):13569-91.
• 2012
  Hollenstein M, Synthesis of deoxynucleoside triphosphates that include proline, urea, or sulfonamide groups and their polymerase incorporation into DNA, Chemistry 2012 Oct;18(42):13320-30.
• 2012
  Hollenstein M, Wojciechowski F, Leumann CJ, Polymerase incorporation of pyrene-nucleoside triphosphates, Bioorg. Med. Chem. Lett. 2012 Jul;22(13):4428-30.
• 2011
  Lam CH, Hipolito CJ, Hollenstein M, Perrin DM, A divalent metal-dependent self-cleaving DNAzyme with a tyrosine side chain, Org. Biomol. Chem. 2011 Oct;9(20):6949-54.
• 2011
  Hipolito CJ, Hollenstein M, Lam CH, Perrin DM, Protein-inspired modified DNAzymes: dramatic effects of shortening side-chain length of 8-imidazolyl modified deoxyadenosines in selecting RNaseA mimicking DNAzymes, Org. Biomol. Chem. 2011 Apr;9(7):2266-73.
• 2011
  Hollenstein M, Expanding the catalytic repertoire of DNAzymes by modified nucleosides, Chimia (Aarau) 2011;65(10):770-5.
• 2009
  Hollenstein M, Hipolito CJ, Lam CH, Perrin DM, A DNAzyme with three protein-like functional groups: enhancing catalytic efficiency of M2+-independent RNA cleavage, Chembiochem 2009 Aug;10(12):1988-92.
• 2009
  Hollenstein M, Hipolito CJ, Lam CH, Perrin DM, A self-cleaving DNA enzyme modified with amines, guanidines and imidazoles operates independently of divalent metal cations (M2+), Nucleic Acids Res. 2009 Apr;37(5):1638-49.
• 2008
  Hollenstein M, Hipolito C, Lam C, Perrin D, In vitro selection of a DNAzyme with three modified nucleotides, Nucleic Acids Symp Ser (Oxf) 2008;(52):73-4.
• 2008
  Hollenstein M, Hipolito C, Lam C, Dietrich D, Perrin DM, A highly selective DNAzyme sensor for mercuric ions, Angew. Chem. Int. Ed. Engl. 2008;47(23):4346-50.
• 2005
  Hollenstein M, Leumann CJ, Fluorinated olefinic peptide nucleic acid: synthesis and pairing properties with complementary DNA, J. Org. Chem. 2005 Apr;70(8):3205-17.
• 2003
  Hollenstein M, Leumann CJ, Synthesis and incorporation into PNA of fluorinated olefinic PNA (F-OPA) monomers, Org. Lett. 2003 May;5(11):1987-90.
• 2003
  Hollenstein M, Gautschi D, Leumann CJ, Fluorinated peptide nucleic acid, Nucleosides Nucleotides Nucleic Acids 2003 May-Aug;22(5-8):1191-4.
• 2000
  D. Franz, M. Hollenstein, Ch. Hollenstein, Diborane nitrogenrammonia plasma chemistry investigated by infrared absorption spectroscopy, Thin Solid Films 2000, 379, 37-44.