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  • Director of Center
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© J.M. Ghigo (Institut Pasteur) and Brigite Arbeille (LBC-ME. Faculté de Médecine de Tours)
Colorized scanning electron microscopy of an E. coli biofilm developing on a glass surface
Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
17
Jun 2015
Keywords
2 Keywords
Ending Date
17
Jun 2020
Status
Ongoing
Members
4
Structures
2
Publications
4

About

 One of the  of the hallmarks of biofilm physiology is its tolerance to a high level of antimicrobials. We are currently investigating the molecular mechanisms that lead to this transient ability to withstand antimicrobial treatments.

Articles on this topic

• Lebeaux, D., V. Leflon-Guibout, J.M. Ghigo, and C. Beloin. (2015). In vitro activity of gentamicin, vancomycin or amikacin combined with EDTA or I-arginine as a lock therapy against a wide spectrum of biofilm-forming clinical strains isolated from catheter-related infections. The Journal of Antimicrobial Chemotherapy. Jun. 70(6) :1704-12. doi: 10.1093.

• Lebeaux, D., A. Chauhan, S. Létoffé, F. Fischer, H. de Reuse, C. Beloin, and J.M. Ghigo. (2014). pH-mediated potentiation of aminoglycosides kills bacterial persisters and eradicates in vivo biofilms. The Journal of Infectious Diseases Nov. 1;210(9):1357-66. doi: 10.1093.

• Bernier, S., D. Lebeaux, A. DeFrancesco, A. Valomon, G. Soubigou,, J.Y. Coppee, J.M. Ghigo, and C. Beloin. (2013). Starvation, together with the SOS response mediates high and biofilm-specific tolerance to the fluoroquinolone ofloxacin. PLoS Genetics Jan. 9(1):e1003144. doi: 10.1371.

 

Review on this topic

Lebeaux, D., J.M. Ghigo, and C. Beloin. (2014). Biofilm-related infections: bridging the gap between clinical management and fundamental aspects of recalcitrance towards antibiotics. Microbiology and Molecular Biology Reviews (MMBR) 

References