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© Research
Publication : Current opinion in genetics & development

Shaping the mouse heart tube from the second heart field epithelium.

Team: Heart Morphogenesis
Member: Sigolène Meilhac
Member: Paul Palmquist-Gomes
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in genetics & development - 10 Jan 2022

Palmquist-Gomes P, Meilhac SM,

Link to Pubmed [PMID] – 35026527

Link to DOI – S0959-437X(21)00141-610.1016/j.gde.2021.101896

Curr Opin Genet Dev 2022 Jan; 73(): 101896

As other tubular organs, the embryonic heart develops from an epithelial sheet of cells, referred to as the heart field. The second heart field, which lies in the dorsal pericardial wall, constitutes a transient cell reservoir, integrating patterning and polarity cues. Conditional mutants have shown that impairment of the epithelial architecture of the second heart field is associated with congenital heart defects. Here, taking the mouse as a model, we review the epithelial properties of the second heart field and how they are modulated upon cardiomyocyte differentiation. Compared to other cases of tubulogenesis, the cellular dynamics in the second heart field are only beginning to be revealed. A challenge for the future will be to unravel key physical forces driving heart tube morphogenesis.