Design of Antiviral drugs for Bronchiolitis Virus using a novel therapeutic target.
New TARGETs for osteoporosis: from mesenchymal stem cells to the regulation of osteogenesis and BONE mass.
Protein-Protein Interactions (PPIs) are involved in most biological process and diseases. With a recently estimated number of 370,000 PPIs in humans, they constitute a large ‘reservoir’ for therapeutic development compared to ‘conventional’ drug targets. […]
This project aims at efficiently storing millions of unique molecular compounds along with some of their already calculated properties. The database named Chem-REST is able to deal with extensive sets of data: millions of […]
In order to boost the identification of low-molecular-weight drugs on protein-protein interactions (PPI), it is essential to properly collect and annotate experimental data about successful examples. This provides the scientific community with the necessary […]
2017Privileged Substructures to Modulate Protein-Protein Interactions, J Chem Inf Model 2017 Oct;57(10):2448-2462.
2016Imbalance in chemical space: How to facilitate the identification of protein-protein interaction inhibitors, Sci Rep 2016 Apr;6:23815.
2015Sampling of conformational ensemble for virtual screening using molecular dynamics simulations and normal mode analysis, Future Med Chem 2015;7(17):2317-31.
2015Stabilization of protein-protein interaction complexes through small molecules, Drug Discov. Today 2016 Jan;21(1):48-57.
2015iPPI-DB: an online database of modulators of protein-protein interactions, Nucleic Acids Res. 2016 Jan;44(D1):D542-7.
2015FAF-Drugs3: a web server for compound property calculation and chemical library design, Nucleic Acids Res. 2015 Jul;43(W1):W200-7.
2015MTiOpenScreen: a web server for structure-based virtual screening, Nucleic Acids Res. 2015 Jul;43(W1):W448-54.
2015[Chemical libraries dedicated to protein-protein interactions], Med Sci (Paris) 2015 Mar;31(3):312-9.
2015In silico design of low molecular weight protein-protein interaction inhibitors: Overall concept and recent advances, Prog. Biophys. Mol. Biol. 2015 Oct;119(1):20-32.
2014Which three-dimensional characteristics make efficient inhibitors of protein-protein interactions?, J Chem Inf Model 2014 Nov;54(11):3067-79.
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