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  • Director of Center
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© Olivier Sperandio
Xray crystal structure (PDB 1YCR) of tumor suppressor p53 (green) bound to MDM2 (magenta), Image carried out using QuteMole v0.4.1

Transversal Projects

Artificial Intelligence at the Institut Pasteur

Institut Pasteur is actively engaged in the application of artificial intelligence methods in biomedical research. In 2018, the Institute has created a Department of Computational Biology to strengthen its expertise in the analysis of […]

Drug Discovery & Screening at Institut Pasteur

The Technological Targeted Action Drug Discovery and Screening (ATC-DDS) coordinates projects and collaborations at the Institut Pasteur Paris campus on therapeutic development. It raises awareness for DDS in basic research projects and stimulates intra-campus […]

Projects

Project
Ongoing
11 Members

Energir: Energy dependent iron import by Gram-negative bacteria

Nadia Izadi-Pruneyre (PI)

Gram-negative bacteria are delimited by an envelope composed of two membranes (the outer and the inner-membranes) separated by the periplasmic space. This envelope includes macromolecular machines that ensure and regulate exchanges between the bacterium […]
Project
Ongoing
6 Members

TheraEPI

Paola Arimondo (PI)

A common phenomenon in most microbial infections is the attenuation of the host’s immediate immune response, allowing for long-term colonization. We and others have shown that many pathogens achieve this by manipulating the epigenetic […]
Project
Ongoing
4 Members

AntiBronchio

Olivier Sperandio (PI)

Design of Antiviral drugs for Bronchiolitis Virus using a novel therapeutic target.
Project
Completed
3 Members

TARGETBONE

Martine Cohen-Solal (PI)

New TARGETs for osteoporosis: from mesenchymal stem cells to the regulation of osteogenesis and BONE mass.
Project
Ongoing
2 Members

PPI-Chem

Olivier Sperandio (PI)

Protein-Protein Interactions (PPIs) are involved in most biological process and diseases. With a recently estimated number of 370,000 PPIs in humans, they constitute a large ‘reservoir’ for therapeutic development compared to ‘conventional’ drug targets. […]

Tools

Tool
Ongoing
7 Members

Chem-REST

Olivier Sperandio (PI)

This project aims at efficiently storing millions of unique molecular compounds along with some of their already calculated properties. The database named Chem-REST is able to deal with extensive sets of data: millions of […]
Tool
Ongoing
12 Members

iPPI-DB Initiative

Olivier Sperandio (PI)

In order to boost the identification of low-molecular-weight drugs on protein-protein interactions (PPI), it is essential to properly collect and annotate experimental data about successful examples. This provides the scientific community with the necessary […]

Publications

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