Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Amandine Buffet, Institut Pasteur
Snapshot of capsule staining of facultative pathogen Klebsiella pneumoniae
Scientific Fields
Diseases
Organisms
Applications
Technique

About

I am interested in microbial communities and the interactions within.

Throughout my PhD I focused on the molecular basis and regulatory processes underlying interspecies interactions, namely competition, in the context of biofilms. I further explored how such competitive interactions affected population dynamics  as well as their role in the probiotic effect in an in vivo model we developed using gnotobiotic Zebrafish.

During my first post doc my research focused on intraspecies interactions from an evolutionary perspective using the social bacterium Myxococcus xanthus. More specifically, i have  addressed (i) the origin of kin discrimination (the ability to discern self and non-self), (ii) adaptation mechanisms of motile versus non motile organisms, and (iii) the mechanisms maintaining diversity across different social groups.

In the GEM lab, I am developing a multidisciplinary project integrating molecular microbiology, population biology, macro- and micro- evolution using Klebsiella pneumoniae as a model. I aim to

  • Quantify the short-term fitness and metabolic costs of capsule production by generating a panel of capsule null mutants and assessing their competitive index against their capsulated variant, and we will correlate this with capsule thickness and expression levels of genes involved in its production and secretion.
  • Understand how capsules affect bacterial adaptation to new environments through hundreds of generations (micro-evolution). I undertook  a mid-term evolution experiment and I am currently analysing how the populations adapted the mutations that emerged through time across the different environments and compare them to those observed in natural populations.
  • Determine the  impact of the different serotypes in Klebsiella genome evolution and the interplay between the capsule and mobile genetic elements..

Projects

CV

2022 – Canetti Prize, Institut Pasteur

2021 – CNRS Bronze Medal

2020–2021 Member of the CID27 of the National Research Committee (CoNRS)

Since 2019 – Co-Chair of the French Society of Microbiology: Section Biodiversity & Evolution.

Since 2019 –Group Leader in Pasteur Institute in the Microbial Evolutionary Genomics lab.

2018– Habilitation in Biology (U Paris Sorbonne, Paris).

Since 2018 – Junior researcher (CR) at the UMR3525 CNRS in Pasteur Institute.

2015-2017- FRM fellow, Postdoc @ Microbial Evolutionary Genomics lab, in Institut Pasteur under the supervision of Eduardo Rocha.

2012-2015 – EMBO Fellow, Postdoc @ Evolutionary Biology group, Velicer lab, (ETH Zürich, Switzerland)

2008-2011– PhD inMicrobiology (U Diderot-Paris VII, France), in Institut Pasteur under the supervision of Jean Marc Ghigo.

2007- MSc in Clinical Microbiology  (U Oviedo, Spain)

 

Publications

Download