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  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
01
Oct 2018
Ending Date
30
Sep 2022
Status
Ongoing
Members
4
Structures
2

About

Capsules are the outermost layer of some bacteria and the first contact between the cell and its environment. Our previous research showed that capsulated bacteria are better colonizers and are dominant in most environments suggesting a positive role for capsules in the genetic diversification of bacteria.

Using Klebsiella pneumoniae as a model system, a nosocomial pathogen causing lung, urinary and liver infections, this project aims to:(i) quantify the short-termfitness and metabolic costs of capsule expression in different environments, (ii) understand how capsules affect bacterial adaptation to new environments, and (iii) determine the role of capsules in genetic transfer and the long-term evolution of genomes.

This multidisciplinary project combining experimental and computational biology will provide an overview to how capsules affect bacterial evolvability and will contribute to identify the adaptive trends of bacteria to better predict evolutionary outcomes in the wild.