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© Christine Schmitt, Meriem El Ghachi, Jean-Marc Panaud
Bactérie Helicobacter pylori en microscopie électronique à balayage. Agent causal de pathologies de l'estomac : elle est responsable des gastrites chroniques, d'ulcères gastriques et duodénaux et elle joue un rôle important dans la genèse des cancers gastriques (adénocarcinomes et lymphomes).

Transversal Projects

Cancer Initiative

With more than 19.3 million new cases in 2020 worldwide, including nearly 400,000 in France, cancer is a common disease that affects or will affect us all one day, directly or indirectly. It is […]

Major Federating Program Microbes & Brain

Program general concept Can microbes influence the brain to maintain health or drive pathology? Will our understanding of the microbes and brain connection generate novel therapeutic approaches? The Major Federating Program Microbes & Brain […]

LabEx Milieu Intérieur

The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system. The Milieu Intérieur Project While the immune […]

LabEx IBEID – Integrative Biology of Emerging Infectious Diseases

Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart and currently coordinated by Carla Saleh and Philippe Bastin, is to develop a […]

Projects

Project
Ongoing
2 Members

Proof of concept of the impact of gut microbiota in the clinical outcome of ICB in mouse models of cancer

Ivo Gomperts Boneca (PI)

We aim to study the adjuvant effects of Enterococcus hirae in antitumoral response. In particular, we want to identify how E. hirae translocates the intestinal barrier and the cells that mediate the antitumor effect.
Project
Ongoing
16 Members

Organ-on-Chip Center

Samy Gobaa (PI)

What’s best to study humans and their infectious deseases than Human emulation system ? It’s now possible at Pasteur to develop real Organs-on-chips with cells from different sources, patient derived or cell line. At […]
Project
Ongoing
6 Members

Inhibition of peptidoglycan assembly complexes

Ivo Gomperts Boneca (PI)

The peptidoglycan (PGN) is an essential macromolecule of bacteria composed of a glycan moiety cross-linked by small stem peptides. The assembly of this macromolecule is achieved by protein complexes that involve synthetases, scaffolding proteins […]
Project
Ongoing
15 Members

Adult neurogenesis and brain plasticity

Pierre-Marie Lledo (PI)

The phenomenon of neurogenesis in adult animals, which has therapeutic potential in treating neurodegenerative diseases, leads to several questions: What controls the pattern of connections formed by new cells? How is the stability of […]
Project
Ongoing
6 Members

Think tank: Mucosal Immunology

Gérard Eberl (PI)

The Think tank Mucosal Immunology gathers several research units form the departments of immunology, microbiology, cellular biology and epidemilogy and infection, as well as from the Institut Imagine (Necker) and Hôpital Paul Brousse. It […]
Project
Completed
5 Members

ERC-2007-Stg-202283-PGNfromSHAPEtoVIR

Ivo Gomperts Boneca (PI)

The role of peptidoglycan in bacterial cell physiology: from bacterial shape to host-microbe interactions Peptidoglycan (PGN) is a major essential and unique component of the cell wall of both of Gram-negative and Gram-positive bacteria. […]
Project
Ongoing
15 Members

When Gut Bacteria Changes Brain Functions

Pierre-Marie Lledo (PI)

We are interested in deciphering the relationships that link gut microbiota with the immune system and the brain. So far, the mechanisms underlying these interplay, and most importantly their consequences, remain largely unknown. Therefore […]
Project
Ongoing
15 Members

Biology and Genetics of Bacterial Cell Wall

Ivo Gomperts Boneca (PI)

  Our research unit aims at studying peptidoglycan (PGN) metabolism to better understand how bacteria assemble a mature and essential PGN that confers rigidity and shape to the cell despite a highly dynamic process […]
Project
Ongoing
9 Members

Symbiotic microbiota and the development and regulation of the immune system

Gérard Eberl (PI)

The symbiotic microbiota plays an essential role at many levels of host physiology, and germfree mice develop a large number of defects. In the intestine, the microbiota metabolises nutrients and toxins to generate an […]

CV

Education:

1989 – 1994 Licenciatura in Applied Chemistry, – specialization in Biotechnology – Faculdade de

Ciências e Tecnologia, Universidade Nova de Lisboa, Monte da Caparica, Portugal

2000 PhD in Biology, Universidade Nova de Lisboa, Portugal

Postdoctoral Training:

2000 – 2004 Post-doctoral fellow, Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, Paris, France

Licensure and Certification:

2010 Habilitation, Université Paris Descartes, France

Academic Appointments:

2004 – 2008    INSERM Research scientist, Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, Paris, France

2008 – 2012    Head of G5 Junior group, G5 Biology and genetics of the bacterial cell wall, Institut Pasteur, Paris, France

2010 – 2015    Research Director (DR2 INSERM)

2013 – present Head of Unit Biology and genetics of the bacterial cell wall, Institut Pasteur, Paris, France

2015 – present Research Director (DR1 INSERM)

2022 – present Head of INSERM Unit U1306 Host-microbe interactions and pathophysiology

Publications

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