We use NMR combined with other biophysical and biochemical techniques to study the structure and the mechanism of self-assembly of functional amyloids formed by Aspergillus fumigatus hydrophobins.
Half-Day Symposium “NMR Beyond Protein Structures”
Biophysical characterization of the translocation process of Bordetella pertussis adenylate cyclase toxin CyaA
This project aims to describe the hydrodynamic and thermodynamic properties of the CyaA toxin and the conformational changes it undergoes during its translocation process across the lipid membranes of Bordetella pertussis (secretion) and of […]
Functional amyloids of the cell wall of the fungal pathogen Aspergillus fumigatus
Aspergillus fumigatus is an opportunistic pathogen than can cause a variety of diseases in immunocompromised individuals that range from allergies to severe pathologies such as invasive aspergillosis. This filamentous fungus has become the major […]
2015(1)H, (13)C and (15)N resonance assignments of the RodA hydrophobin from the opportunistic pathogen Aspergillus fumigatus, Biomol NMR Assign 2015 Apr;9(1):113-8.
2013New insights for native production of MSP1(19), the disulfide-rich C-terminal fragment from Plasmodium falciparum merozoite surface protein 1, PLoS ONE 2013;8(2):e57086.
2013Solution structure of an archaeal DNA binding protein with an eukaryotic zinc finger fold, PLoS ONE 2013;8(1):e52908.
2012Hydrophobins–unique fungal proteins, PLoS Pathog. 2012;8(5):e1002700.
2010Characterization of the regions involved in the calcium-induced folding of the intrinsically disordered RTX motifs from the bordetella pertussis adenylate cyclase toxin, J. Mol. Biol. 2010 Mar;397(2):534-49.
2010Calmodulin-induced conformational and hydrodynamic changes in the catalytic domain of Bordetella pertussis adenylate cyclase toxin, Biochemistry 2010 Jan;49(2):318-28.
2009Structure, function, and targets of the transcriptional regulator SvtR from the hyperthermophilic archaeal virus SIRV1, J. Biol. Chem. 2009 Aug;284(33):22222-37.
2008RTX calcium binding motifs are intrinsically disordered in the absence of calcium: implication for protein secretion, J. Biol. Chem. 2009 Jan;284(3):1781-9.
2006A novel archaeal regulatory protein, Sta1, activates transcription from viral promoters, Nucleic Acids Res. 2006;34(17):4837-45.
2006Diversity and junction residues as hotspots of binding energy in an antibody neutralizing the dengue virus, FEBS J. 2006 Jan;273(1):34-46.
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