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Hydrophobin: functional amyloids from the fungal pathogen Aspergillus fumigatus
Iñaki Guijarro (PI)
Proteins from the hydrophobin family are produced by filamentous fungi in a soluble form, which spontaneously self-assemble at air/water or hydrophobic/hydrophilic interfaces to produce amphipathic layers and accomplish their biological role. Hydrophobin layers consist […]
Biophysical characterization of the translocation process of Bordetella pertussis adenylate cyclase toxin CyaA
Alexandre Chenal (PI)
This project aims to describe the hydrodynamic and thermodynamic properties of the CyaA toxin and the conformational changes it undergoes during its translocation process across the lipid membranes of Bordetella pertussis (secretion) and of […]
Functional amyloids of the cell wall of the fungal pathogen Aspergillus fumigatus
Iñaki Guijarro (PI)
Aspergillus fumigatus is an opportunistic pathogen than can cause a variety of diseases in immunocompromised individuals that range from allergies to severe pathologies such as invasive aspergillosis. This filamentous fungus has become the major […]
Nuclear Magnetic Resonance spectrometers
Muriel Delepierre (PI)
NMR spectroscopy 800 MHz NMR spectrometer installed in Pasteur Three NMR spectrometers with 11.7, 14 and 18 Tesla magnets (500 MHz, 600 MHz and 800Mhz), well suited for study of biomolecules are currently in […]
2019Assembly and disassembly of Aspergillus fumigatus conidial rodlets, The Cell Surface.
2019Cn29, a novel orphan peptide found in the venom of the scorpion Centruroides noxius: Structure and function, Toxicon 2019 Sep;167:184-191.
2019The puzzling construction of the conidial outer layer of Aspergillus fumigatus., Cell Microbiol 2019 05; 21(5): e12994.
2018Probing Structural Changes during Self-assembly of Surface-Active Hydrophobin Proteins that Form Functional Amyloids in Fungi., J Mol Biol 2018 10; 430(20): 3784-3801.
2018Calcium-dependent disorder-to-order transitions are central to the secretion and folding of the CyaA toxin of Bordetella pertussis, the causative agent of whooping cough, Toxicon 2018 Jul;149:37-44.
2017Role of Hydrophobins in Aspergillus fumigatus, J Fungi (Basel) 2017 Dec;4(1).
2015(1)H, (13)C and (15)N resonance assignments of the RodA hydrophobin from the opportunistic pathogen Aspergillus fumigatus, Biomol NMR Assign 2015 Apr;9(1):113-8.
2013New insights for native production of MSP1(19), the disulfide-rich C-terminal fragment from Plasmodium falciparum merozoite surface protein 1, PLoS ONE 2013;8(2):e57086.
2013Solution structure of an archaeal DNA binding protein with an eukaryotic zinc finger fold, PLoS ONE 2013;8(1):e52908.
2012Hydrophobins–unique fungal proteins, PLoS Pathog. 2012;8(5):e1002700.
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