My research interests are mainly focused on the structure-function relationships of macromolecules through multidisciplinary approaches. My studies have been concentrated on crucial enzymes belonging to the nucleotide metabolism, in particular nucleoside monophosphate kinases (NMPKs) and more recently IMP dehydrogenase (IMPDH). My work has provided new insights into their functional regulation. Moreover, I have found peculiar enzymatic or structural features that make them potentiel targets for the design of new antibacterial drugs. In this context, I have set up in 2007 a screening platform on chemical libraries, and since then I have been managing the screening activity (acronym CBC for “Criblage Biologique et Chimiothèques”) dedicated to in-house or collaborative projects, mainly in the field of anti-infectious agents. This has led me to identify research tools or chemical starting points for therapeutic applications.
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