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© MPI f. Dynamik und Selbstorganisation

Transversal Projects

Brain connectivity and neurodegenerative diseases

The brain is a complex organ, and its well-being depends on the harmonic interactions with the rest of our body. Nearly all brain disorders manifest themselves in the dysfunction of communication between brain cells […]

Quantitative biology

The Quantitative Biology program of the Institut Pasteur is intended to facilitate research and education at the interface of biology and the more quantitative sciences. One of the major aims of Quantitative Biology is thus to […]

Projects

Project
Ongoing
4 Members

Superresolution imaging of the diversity macromolecular organization at synapses

David DiGregorio (PI)

We have installed a stimulation emission depletion (STED) microscope in order to assess the diversity of the nanoscale organization of synaptic molecules thought to underly synaptic strength and dynamics. Figure 1. Confocal and STED […]
Project
Ongoing
5 Members

Cerebellar circuit representation of precisely timed behaviors

David DiGregorio (PI)

Our CC model predicts that MF-GC STP diversity drives a temporal diversity of GC activity that enables temporal learning by PCs.  Population measurements of GC spiking activity are not readily available. We will use […]
Project
Ongoing
4 Members

Statistical inference of synaptic and circuit models

David DiGregorio (PI)

under construction
Project
Ongoing
3 Members

Computational modeling of cerebellar cortical circuit dynamics with dynamic synapses

David DiGregorio (PI)

Computational implications of functional synaptic diversity – a formalized hypothesis. Precise neural representations of “time” are essential for well-timed behaviors [1], but the cellular and circuit mechanisms are largely unknown.  We previously showed that […]
Project
Ongoing
5 Members

Synaptic basis of multisensory information processing in the cerebellar cortex

David DiGregorio (PI)

Synaptic representation of multisensory information The GC layer of the CC is thought to pre-process incoming mossy fiber (MF) activity so that PCs can more easily distinguish distinct patterns associated specific sensory contexts. The […]
Project
Ongoing
3 Members

Dendritic computations

David DiGregorio (PI)

Contribution of dendritic integration and electrical synapses to circuit computations. Nonlinear summation of synaptic potentials in dendrites is thought to increase computational power of neurons and has been shown to contribute to feature selectivity […]
Project
Ongoing
4 Members

Molecular mechanisms of synaptic diversity

David DiGregorio (PI)

Molecular and cellular determinants of functional synaptic  diversity At canonical fast synapses nanoscale alterations in the number, density and location of synaptic vesicles, calcium channels, receptors and fusion proteins play a critical role in […]

Publications

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