Brain connectivity and neurodegenerative diseases
The brain is a complex organ, and its well-being depends on the harmonic interactions with the rest of our body. Nearly all brain disorders manifest themselves in the dysfunction of communication between brain cells […]
Superresolution imaging of the diversity macromolecular organization at synapses
We have installed a stimulation emission depletion (STED) microscope in order to assess the diversity of the nanoscale organization of synaptic molecules thought to underly synaptic strength and dynamics. Figure 1. Confocal and STED […]
Cerebellar circuit representation of precisely timed behaviors
Our CC model predicts that MF-GC STP diversity drives a temporal diversity of GC activity that enables temporal learning by PCs. Population measurements of GC spiking activity are not readily available. We will use […]
Statistical inference of synaptic and circuit models
Computational modeling of cerebellar cortical circuit dynamics with dynamic synapses
Computational implications of functional synaptic diversity – a formalized hypothesis. Precise neural representations of “time” are essential for well-timed behaviors , but the cellular and circuit mechanisms are largely unknown. We previously showed that […]
Synaptic basis of multisensory information processing in the cerebellar cortex
Synaptic representation of multisensory information The GC layer of the CC is thought to pre-process incoming mossy fiber (MF) activity so that PCs can more easily distinguish distinct patterns associated specific sensory contexts. The […]
Contribution of dendritic integration and electrical synapses to circuit computations. Nonlinear summation of synaptic potentials in dendrites is thought to increase computational power of neurons and has been shown to contribute to feature selectivity […]
Molecular mechanisms of synaptic diversity
Molecular and cellular determinants of functional synaptic diversity At canonical fast synapses nanoscale alterations in the number, density and location of synaptic vesicles, calcium channels, receptors and fusion proteins play a critical role in […]
2021A first-passage approach to diffusion-influenced reversible binding and its insights into nanoscale signaling at the presynapse., Sci Rep 2021 Mar; 11(1): 5377.
2020Feed-forward recruitment of electrical synapses enhances synchronous spiking in the mouse cerebellar cortex., 2020 Sep; 9(): .
2019Distinct Nanoscale Calcium Channel and Synaptic Vesicle Topographies Contribute to the Diversity of Synaptic Function, Neuron 2019 Sep;.
2019Underpinning heterogeneity in synaptic transmission by presynaptic ensembles of distinct morphological modules, Nat Commun 2019 02;10(1):826.
2018Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR, Nat. Methods 2018 Nov;15(11):936-939.
2018Variations in Ca Influx Can Alter Chelator-Based Estimates of Ca Channel-Synaptic Vesicle Coupling Distance, J. Neurosci. 2018 Apr;38(16):3971-3987.
2016Differential Dendritic Integration of Synaptic Potentials and Calcium in Cerebellar Interneurons, Neuron 2016 Aug;91(4):837-850.
2016A Role for Synaptic Input Distribution in a Dendritic Computation of Motion Direction in the Retina, Neuron 2016 Mar;89(6):1317-30.
2015Optical control of NMDA receptors with a diffusible photoswitch, Nat Commun 2015;6:8076.
2015Synaptic diversity enables temporal coding of coincident multisensory inputs in single neurons, Nat. Neurosci. 2015 May;18(5):718-27.
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