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© Research
Publication : Neuron

Differential Dendritic Integration of Synaptic Potentials and Calcium in Cerebellar Interneurons

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Neuron - 17 Aug 2016

Tran-Van-Minh A, Abrahamsson T, Cathala L, DiGregorio DA

Link to Pubmed [PMID] – 27537486

Neuron 2016 Aug;91(4):837-850

Dendritic voltage integration determines the transformation of synaptic inputs into output firing, while synaptic calcium integration drives plasticity mechanisms thought to underlie memory storage. Dendritic calcium integration has been shown to follow the same synaptic input-output relationship as dendritic voltage, but whether similar operations apply to neurons exhibiting sublinear voltage integration is unknown. We examined the properties and cellular mechanisms of these dendritic operations in cerebellar molecular layer interneurons using dendritic voltage and calcium imaging, in combination with synaptic stimulation or glutamate uncaging. We show that, while synaptic potentials summate sublinearly, concomitant dendritic calcium signals summate either linearly or supralinearly depending on the number of synapses activated. The supralinear dendritic calcium triggers a branch-specific, short-term suppression of neurotransmitter release that alters the pattern of synaptic activation. Thus, differential voltage and calcium integration permits dynamic regulation of neuronal input-output transformations without altering intrinsic nonlinear integration mechanisms.

http://www.ncbi.nlm.nih.gov/pubmed/27537486