Molecular mechanisms of bacterial cell division
How cells grow and divide with extraordinary accuracy is at the center of all forms of life and has been a focus of research for many decades. Even though our understanding of the underlying […]
Tuberculosis still remains a major threat for public health, with one-third of the world population latently infected, and more than one million deaths per year according to the WHO. Among the factors that have […]
Acyl-CoAs are the major metabolic carriers of carbon in living organisms. The most conserved ways to their synthesis include the oxidative decarboxylation of α-ketoacids carried out by three distinct enzymatic machineries: the pyruvate dehydrogenase […]
Type II protein secretion mechanism
Many Gram-negative bacteria secrete stably folded or even multimeric proteins across the outer membrane. The secreted substrates are often virulence factors like hydolases or toxins that contribute to the ability of bacteria to adapt […]
Structural studies of type II topoisomerases
Our main research projects focus on structural and functional studies of M. tuberculosis DNA gyrase and aim to understand the structural dynamics of DNA recognition by DNA gyrase and the quinolone resistance mechanisms […]
PknA/PknB in mycobacterial cell division
The genes pknA and pknB are located near the origin of replication in M. tuberculosis and are part of a conserved operon that also includes pstP (coding the only known Ser/Thr protein phosphatase […]
Control of glutamate metabolism in mycobacteria
We recently demonstrated the existence of a phosphorylation-dependent control of glutamate metabolism in mycobacteria, in collaboration with H. O’Hare’s group in Leicester (O’Hare et al., 2008). Our results were supported by similar observations […]
2020Essential dynamic interdependence of FtsZ and SepF for Z-ring and septum formation in Corynebacterium glutamicum., Nat Commun 2020 Apr; 11(1): 1641.
2020Unexpected electron spin density on the axial methionine ligand in Cu suggests its involvement in electron pathways, Chem. Commun. (Camb.) 2020 Jan;56(8):1223-1226.
2019High-Throughput Crystallization Pipeline at the Crystallography Core Facility of the Institut Pasteur, Molecules 2019 Dec;24(24).
2019Conformational transitions in the active site of mycobacterial 2-oxoglutarate dehydrogenase upon binding phosphonate analogues of 2-oxoglutarate: From a Michaelis-like complex to ThDP adducts, J. Struct. Biol. 2019 11;208(2):182-190.
2019Arabidopsis thaliana Hcc1 is a Sco-like metallochaperone for Cu assembly in Cytochrome c Oxidase, FEBS J. 2020 Feb;287(4):749-762.
2019Structural insights into the functional versatility of an FHA domain protein in mycobacterial signaling, Sci Signal 2019 05;12(580).
2019Novel mechanistic insights into physiological signaling pathways mediated by mycobacterial Ser/Thr protein kinases, Genes Immun. 2019 Apr;.
2019Double autoinhibition mechanism of signal transduction ATPases with numerous domains (STAND) with a tetratricopeptide repeat sensor, Nucleic Acids Res. 2019 Apr;47(7):3795-3810.
2019The crystal structure of Rv2991 from Mycobacterium tuberculosis: An F binding protein with unknown function, J. Struct. Biol. 2019 May;206(2):216-224.
2019Overall Structures of Mycobacterium tuberculosis DNA Gyrase Reveal the Role of a Corynebacteriales GyrB-Specific Insert in ATPase Activity, Structure 2019 04;27(4):579-589.e5.
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