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© MPI f. Dynamik und Selbstorganisation
Publication : Nature communications

Synaptic basis of a sub-second representation of time in a neural circuit model.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature communications - 22 Dec 2022

Barri A, Wiechert MT, Jazayeri M, DiGregorio DA

Link to Pubmed [PMID] – 36550115

Link to DOI – 10.1038/s41467-022-35395-y

Nat Commun 2022 Dec; 13(1): 7902

Temporal sequences of neural activity are essential for driving well-timed behaviors, but the underlying cellular and circuit mechanisms remain elusive. We leveraged the well-defined architecture of the cerebellum, a brain region known to support temporally precise actions, to explore theoretically whether the experimentally observed diversity of short-term synaptic plasticity (STP) at the input layer could generate neural dynamics sufficient for sub-second temporal learning. A cerebellar circuit model equipped with dynamic synapses produced a diverse set of transient granule cell firing patterns that provided a temporal basis set for learning precisely timed pauses in Purkinje cell activity during simulated delay eyelid conditioning and Bayesian interval estimation. The learning performance across time intervals was influenced by the temporal bandwidth of the temporal basis, which was determined by the input layer synaptic properties. The ubiquity of STP throughout the brain positions it as a general, tunable cellular mechanism for sculpting neural dynamics and fine-tuning behavior.

https://pubmed.ncbi.nlm.nih.gov/36550115