Andrés Alcover, Professor at the Institut Pasteur, is currently the Head of the Lymphocyte Cell Biology Unit at the Insitut Pasteur and the Director of the INSERM Unit-1221, Immunomodulation and Infection. He got his PhD degree at the Universidad Autonoma, Madrid, Spain in 1982. He further trained as a postdoctoral fellow at the Center of Molecular Biology in Madrid and at the Dana-Farber Cancer Institute, Harvard Medical School in Boston MA, USA. He joined the Institut Pasteur as a staff scientist at the end of 1987. His main research interest for many years has been the molecular mechanisms that control T lymphocyte activation and their subversion by retroviruses that infect T lymphocytes.
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About
Courses
Pasteur Course Advanced immunology
This intensive six-week course, including practical work, lectures, and scientific analysis workshops, covers the fundamental themes of cellular and molecular immunology. For more information and program, please, visit the course webpage.
2025-11-17 09:00:00
2026-01-09 18:00:00
Europe/Paris
Pasteur Course Advanced immunology
This intensive six-week course, including practical work, lectures, and scientific analysis workshops, covers the fundamental themes of cellular and molecular immunology. For more information and program, please, visit the course webpage.
Institut Pasteur, Rue du Docteur Roux, Paris, France
Transversal Projects
Projects
Former Teams
Publications
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2024Cancer-on-a-chip model shows that the adenomatous polyposis coli mutation impairs T cell engagement and killing of cancer spheroids, Proceedings of the National Academy of Sciences of the United States of America, 2024, 121 (11), pp.e2316500121. ⟨10.1073/pnas.2316500121⟩.
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2023T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations, Frontiers in Immunology, 2023, 14, pp.1163466. ⟨10.3389/fimmu.2023.1163466⟩.
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2022The tumor suppressor adenomatous polyposis coli regulates T lymphocyte migration., Sci Adv 2022 Apr; 8(15): eabl5942.
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2021Cell Polarity Regulators, Multifunctional Organizers of Lymphocyte Activation and Function., Biomed J 2021 Oct; (): .
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2020Coordinating Cytoskeleton and Molecular Traffic in T Cell Migration, Activation, and Effector Functions., Front Cell Dev Biol 2020 ; 8(): 591348.
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2020Adenomatous Polyposis Coli Modulates Actin and Microtubule Cytoskeleton at the Immunological Synapse to Tune CTL Functions., Immunohorizons 2020 06; 4(6): 363-381.
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2020ERM-Dependent Assembly of T Cell Receptor Signaling and Co-stimulatory Molecules on Microvilli prior to Activation., Cell Rep 2020 Mar; 30(10): 3434-3447.e6.
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2018HIV-1 Nef Hijacks Lck and Rac1 Endosomal Traffic To Dually Modulate Signaling-Mediated and Actin Cytoskeleton-Mediated T Cell Functions., J. Immunol. 2018 11; 201(9): 2624-2640.
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2018Cell Biology of T Cell Receptor Expression and Regulation., Annu. Rev. Immunol. 2018 04; 36(): 103-125.
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2017Adenomatous Polyposis Coli Defines Treg Differentiation and Anti-inflammatory Function through Microtubule-Mediated NFAT Localization., Cell Rep 2017 Oct; 21(1): 181-194.
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