Timeline

Ariel Mechaly

Research Engineer

18 Oct 2024

publication

Molecular mechanism of a triazole-containing inhibitor of Mycobacterium tuberculosis DNA gyrase.

05 Apr 2024

publication

Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1.

18 Mar 2024

publication

Cryo-EM structures of type IV pili complexed with nanobodies reveal immune escape mechanisms

05 Feb 2024

publication

Structural and enzymatic evidence for the methylation of the ACK1 tyrosine kinase by the histone lysine methyltransferase SETD2.

06 Jan 2024

publication

Ton motor conformational switch and peptidoglycan role in bacterial nutrient uptake.

10 Aug 2023

publication

High resolution cryo-EM and crystallographic snapshots of the actinobacterial two-in-one 2-oxoglutarate dehydrogenase.

20 Jun 2023

publication

Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMPDHs.

02 Feb 2023

publication

Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system.

01 Feb 2023

news

Bacterial pathogenicity: improving understanding of an essential process – molecule secretion

11 Jan 2023

publication

The c-di-AMP-binding protein CbpB modulates the level of ppGpp alarmone in Streptococcus agalactiae.

01 Jan 2023

publication

Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity.

09 Aug 2022

publication

Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium.

12 Feb 2022

publication

Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target.

01 Jan 2022

publication

Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins.

22 Nov 2021

publication

Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy.

01 May 2021

publication

A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells.

13 Jan 2021

publication

Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein.

06 Nov 2020

publication

Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners.

06 Jul 2020

publication

Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker.

11 Mar 2020

publication

An asymmetric sheath controls flagellar supercoiling and motility in the leptospira spirochete.

05 Dec 2019

publication

High-Throughput Crystallization Pipeline at the Crystallography Core Facility of the Institut Pasteur

31 Jul 2019

publication

Directly Sequenced Genomes of Contemporary Strains of Syphilis Reveal Recombination-Driven Diversity in Genes Encoding Predicted Surface-Exposed Antigens

17 Oct 2018

publication

Evidence of Alternative Splicing as a Regulatory Mechanism for Kissr2 in Pejerrey Fish

04 Aug 2018

publication

Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance

15 Jul 2018

publication

Structural insights into the signalling mechanisms of two-component systems

23 Feb 2018

publication

Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic

20 Aug 2017

publication

Snapshots of the Signaling Complex DesK:DesR in Different Functional States Using Rational Mutagenesis and X-ray Crystallography.

25 May 2017

publication

Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase

21 Feb 2017

publication

Crystallization of FcpA from Leptospira, a novel flagellar protein that is essential for pathogenesis

12 Dec 2016

publication

Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action

18 Feb 2016

publication

What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira

10 Dec 2015

publication

Structural Basis of Pullulanase Membrane Binding and Secretion Revealed by X-Ray Crystallography, Molecular Dynamics and Biochemical Analysis

11 May 2015

team

Structural Microbiology

17 Feb 2015

team

Crystallography

18 Nov 2014

publication

Allosteric activation of bacterial response regulators: the role of the cognate histidine kinase beyond phosphorylation

13 May 2014

publication

Potent and specific inhibition of glycosidases by small artificial binding proteins (affitins)

28 Jan 2014

publication

Segmental helical motions and dynamical asymmetry modulate histidine kinase autophosphorylation

21 Jun 2012

publication

Pores of the toxin FraC assemble into 2D hexagonal clusters in both crystal structures and model membranes

03 May 2012

publication

Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis.

09 Feb 2011

publication

Structural insights into the oligomerization and architecture of eukaryotic membrane pore-forming toxins

21 Mar 2009

publication

Crystallization and preliminary crystallographic analysis of fragaceatoxin C, a pore-forming toxin from the sea anemone Actinia fragacea

11 Mar 2008

publication

A plate holder for non-destructive testing of mesophase crystallization assays

08 Jul 2006

publication

A little guide for advanced search:

Molecular mechanism of a triazole-containing inhibitor of Mycobacterium tuberculosis DNA gyrase.

Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1.

Cryo-EM structures of type IV pili complexed with nanobodies reveal immune escape mechanisms

Structural and enzymatic evidence for the methylation of the ACK1 tyrosine kinase by the histone lysine methyltransferase SETD2.

Ton motor conformational switch and peptidoglycan role in bacterial nutrient uptake.

High resolution cryo-EM and crystallographic snapshots of the actinobacterial two-in-one 2-oxoglutarate dehydrogenase.

Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMPDHs.

Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system.

Bacterial pathogenicity: improving understanding of an essential process – molecule secretion

The c-di-AMP-binding protein CbpB modulates the level of ppGpp alarmone in Streptococcus agalactiae.

Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity.

Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium.

Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target.

Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins.

Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy.

A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells.

Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein.

Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners.

Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker.

An asymmetric sheath controls flagellar supercoiling and motility in the leptospira spirochete.

High-Throughput Crystallization Pipeline at the Crystallography Core Facility of the Institut Pasteur

Directly Sequenced Genomes of Contemporary Strains of Syphilis Reveal Recombination-Driven Diversity in Genes Encoding Predicted Surface-Exposed Antigens

Evidence of Alternative Splicing as a Regulatory Mechanism for Kissr2 in Pejerrey Fish

Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance

Structural insights into the signalling mechanisms of two-component systems

Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic

Snapshots of the Signaling Complex DesK:DesR in Different Functional States Using Rational Mutagenesis and X-ray Crystallography.

Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase

Crystallization of FcpA from Leptospira, a novel flagellar protein that is essential for pathogenesis

Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action

What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira

Structural Basis of Pullulanase Membrane Binding and Secretion Revealed by X-Ray Crystallography, Molecular Dynamics and Biochemical Analysis

Structural Microbiology

Crystallography

Allosteric activation of bacterial response regulators: the role of the cognate histidine kinase beyond phosphorylation

Potent and specific inhibition of glycosidases by small artificial binding proteins (affitins)

Segmental helical motions and dynamical asymmetry modulate histidine kinase autophosphorylation

Pores of the toxin FraC assemble into 2D hexagonal clusters in both crystal structures and model membranes

Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis.

Structural insights into the oligomerization and architecture of eukaryotic membrane pore-forming toxins

Crystallization and preliminary crystallographic analysis of fragaceatoxin C, a pore-forming toxin from the sea anemone Actinia fragacea

A plate holder for non-destructive testing of mesophase crystallization assays

Crystal structure of the temperature-sensitive and allosteric-defective chaperonin GroELE461K